1.
Dokl Biol Sci
; 417: 420-2, 2007.
Article
in English
| MEDLINE
| ID: mdl-18274479
Subject(s)
Eye Injuries, Penetrating/drug therapy , Eye Injuries, Penetrating/immunology , Stress, Physiological/immunology , alpha-Fetoproteins/therapeutic use , Animals , Antibody-Producing Cells/drug effects , Cicatrix/immunology , Erythrocytes/immunology , Male , Rats , Rats, Wistar , Sheep , Wound Healing/drug effects , Wound Healing/immunology
2.
Bull Exp Biol Med
; 141(4): 536-43, 2006 Apr.
Article
in English
| MEDLINE
| ID: mdl-17152387
ABSTRACT
The effect of "Profetal", a preparation containing human alpha-fetoprotein, on proliferative activity and differentiation of mononuclear leukocytes isolated from donor peripheral blood was studied in cultures with serum-free media. The results suggest that human alpha-fetoprotein in effective doses stimulates proliferation and blast transformation of cultured peripheral blood mononuclear leukocytes with the formation of CD34+/CD45+ hemopoietic precursor cells. This phenomenon of ex vivo generation of hemopoietic precursor cells using human alpha-fetoprotein can be important for clinical oncology, specifically, for the development of adaptive cell therapies.
