[Increase in T-cell level in the peripheral blood of women with fractures in anamnesis during postmenopause period].

44 postmenopausal patients (45-76 years of old) have been observed. Interrelationship between composition and functional activity of peripheral blood cells, TNF-alpha level in the serum and bone density in postmenopausal women has been analyzed. It was established that the increase in neutrophil activity in women with osteoporosis, the high level of immune complexes are accompanied by the high level of IgG and autoantibodies to DNA. These results allow suggesting the presence of chronic inflammatory or immune processes taken place in postmenopausal women with osteoporosis. Increase in CD3+ cells percent was established in women with fracture in anamnesis. Obtained results allow suggesting the possibility that T-cells may play a role in the occurrence of fractures.

[The characteristics of the development of the immune function in the transplanted spleen of newborn mouse pups in recipients of different ages. I. The effect of the cells in the stromal microenvironment of the transplant]. / Osoblyvosti rozvytku imunnoï funktsiï peresadzhenoï selezinky novonarodzhenykh mysheniat retsypiientam riznoho viku. I. Vplyv klityn stromal'noho mikrootochennia transplantata.

The age-related changes in the cell composition, immune response to SRBC and proliferative activity of T- and B-cells in vitro were determined in neonatal spleen grafted to CBA/Ca female mice of different ages. The dependence of the immune response upon the recipient's age was observed. This result indicate that "young" transplant stromal cells are incapable of immune response increase in the old recipients. Analysis of the T- and B-cells content in the spleen grafted to the recipients of different ages demonstrated no differences. The decrease of the T-cell proliferative activity and existence of the inverse correlative connection between content of the T-cells and PFCs in spleen grafted to the old recipients were demonstrated. Additional neonatal thymus transplantation is proposed as tools for correction of the age-related changes in the immune function.