[NSAID-induced damage to the gastrointestinal mucosa]. / Vliianie nesteroidnykh protivovospalitel'nykh preparatov na sootnoshenie agressivnykh i zashchitnykh faktorov v slizistoi obolochke organov pishchevareniia.

Non-steroid antiinflammatory drug (NSAID)-related gastropathy is regarded as the most important NSAID-induced complication. The above term is used to signify erosive and ulcerous injuries to the stomach and duodenum, having a characteristic clinical picture.

[Correction of metabolic disturbances in patients with cholestasis]. / Korrektsiia metabolicheskikh narushenii u bol'nykh s kholestazom.

The nosologic and etiopathogenetic structure of the cholestatic syndrome encountered both in surgical and therapeutical practice is described.

[The ultrastructural, histomorphological and histoenzymological changes in the gastric mucosa in different forms of chronic gastroduodenitis]. / Ul'trastrukturnye, gistomorfologicheskie i gistoénzimologicheskie izmeneniia slizistoi obolochki zheludka pri razlichnykh formakh khronicheskogo gastroduodenita.

Investigations designed to study gastric mucosa (GM) in patients with chronic primary gastroduodenitis with the aid of electron microscopy showed the abnormal changes in the cellular, subcellular membranes and capillaries to be of the same type as they are in peptic ulcer (PU) though poorly manifest. Changes in GM under chronic atrophic gastroduodenitis (ChGD) suggested involutive changes while in chronic secondary gastroduodenitis (ChSGD) it was generally not different from the mucosa ultrastructure in healthy subjects except for changes in surface epithelium. Based on the histoenzymologic studies it has been ascertained that in ChPGD there occurs a rise in lysosomal enzymes similar to that encountered in PU, reflecting the intensity of catabolic processes, decrease in the activity of enzymes of the capillary wall and mitochondria respiratory chain against the background of compensatory enhancement of the activity of the glycolytic enzyme lactate dehydrogenase. In ChAGD the activity of all the enzymes was low, while in ChSGD it did not differ significantly from that in healthy subjects.

[The use of tardyferon in the combined treatment of patients with chronic atrophic gastritis and peptic ulcer complicated by hemorrhage]. / Primenenie tardiferona v kompleksnom lechenii bol'nykh khronicheskim atroficheskim gastritom i iazvennoi bolezn'iu, oslozhnennoi krovotecheniem.

Tardipherone is capable of maximum absorption in the initial portion of small intestine, iron being in its retarding form, which fact ensures a prolonged action of the drug, mucoprotease being a part of tardipherone composition acting to guard gastric and duodenal mucosae against irritating effect of iron. Tardipherone was found to be efficacious in treating patients with ulcer disease complicated by bleeding. Under its effect the hemogram indices get normalized as does the ratio of aggressive to protective factors of gastric juice, which factors play a major part in the emergent relapse of the illness. The use of tardipherone was found to be justified in the treatment of patients with chronic atrophic gastritis, being associated with gratifying shifts in the clinical picture of the condition and improvement in the hemogram characteristics.

[The use of Smecta for the treatment of the basic digestive tract diseases]. / Primenenie smekty dlia lecheniia osnovnykh zabolevanii pishchevaritel'nogo kanala.

The indices for the gastric contents aggression and protection ratio returned to normal in patients with peptic ulcer and preulcerous condition during the treatment with smekta due to a decrease in proteolytic activity and increase in the synthesis of the mucus protective proteins. Monitoring of intragastric pH in the body of the stomach throughout 24 hours in patients with peptic ulcer of duodenal location revealed significant acid-neutralizing effect of smekta. Patients with nonspecific ulcerous colitis enjoyed freedom of side effects as a result of the use of salofalk and derived full therapeutic benefit from this treatment. Under the effect of smekta there occurred suppression of the growth of pathogenic proteolytic flora, improvement of qualitative properties of coli flora and growth of sugar-lytic flora in patients with intestinal dysbiosis. According to the data available, smekta strengthens the mucous barrier by improving the conformation of the mucus structural elements.

[A method for examining patients with chronic gastroduodenitis]. / Metodika obsledovaniia bol'nykh khronicheskimi gastroduodenitami.

The following method of examination of patients with chronic primary gastroduodenitis is proposed: 1) clinical examination; 2) roentgen and endoscopic examination; 3) assessment of genetic predisposition to ulcer disease; 4) examination of the acid- and pepsin-forming gastric function; 5) determination of the pepsin aggression ratio; 6) determination of the gastric juice defense ratio; 7) biochemical examination of the amino acid composition of the gastric mucosa; 8) determination of the lipid peroxidation intensity. The obtained data indicate that chronic primary gastroduodenitis is not a pre-disease but an initial stage of ulcer disease.