ABSTRACT
A novel and facile method was developed to produce hybrid graphene oxide (GO)-polyelectrolyte (PE) capsules using erythrocyte cells as templates. The capsules are easily produced through the layer-by-layer technique using alternating polyelectrolyte layers and GO sheets. The amount of GO and therefore its coverage in the resulting capsules can be tuned by adjusting the concentration of the GO dispersion during the assembly. The capsules retain the approximate shape and size of the erythrocyte template after the latter is totally removed by oxidation with NaOCl in water. The PE/GO capsules maintain their integrity and can be placed or located on other surfaces such as in a device. When the capsules are dried in air, they collapse to form a film that is approximately twice the thickness of the capsule membrane. AFM images in the present study suggest a film thickness of approx. 30 nm for the capsules in the collapsed state implying a thickness of approx. 15 nm for the layers in the collapsed capsule membrane. The polyelectrolytes used in the present study were polyallylamine hydrochloride (PAH) and polystyrenesulfonate sodium salt (PSS). Capsules where characterized by transmission electron microscopy (TEM), atomic force microscopy (AFM), dynamic light scattering (DLS) and Raman microscopy, the constituent layers by zeta potential and GO by TEM, XRD, and Raman and FTIR spectroscopies.
ABSTRACT
El hipertiroidismo en la infancia ocurre con una frecuencia relativa del 5 por ciento. La presencia de epilepsia y tirotoxicosis es poco frecuente. De acuerdo a la revisión de la literatura no existen reportes de esta asociación en niños. Descubrimos un paciente de cuatro años de edad con enfermedad de Graves que desarrolló crisis convulsiva tónico-clónica generalizada seguida de estado epiléptico parcial motor en hemicuerpo izquierdo. El EEG mostró actividad epileptiforme y la TC e IRM de cráneo resultaron normales. El EEG se normalizó al controlar el hipertiroidismo. De acuerdo a la revisión de la literatura, este es el primer caso reportado de epilepsia y tirotoxicosis en nuestro país. Se comentan los posibles mecanismos fisiopatológicos de las convulsiones en nuestro paciente con tirotoxicosis
