ABSTRACT
Oncological impact of tumor-infiltrating lymphocytes (TILs) in melanoma remains controversial. We aimed to determine the significance of TILs on melanoma-specific survival (MSS), recurrence-free survival (RFS), and sentinel lymph node status (SLN). A retrospective analysis of patients undergoing melanoma resection during the period 2009-2019 was performed. Using the Melanoma Institute Australia grading system for TILs, the cohort was divided into two groups: group 1 (G1), patients with TILs grades 1, 2, or 3 and Group 2 (G2), patients with TILs grade 0. From a total of 386 melanoma resections, 151 (39%) were included in G1 and 39 (10%) in G2. Among the 151 patients who underwent SLN biopsy, the positivity rate according to the TILs grades 0, 1, 2, and 3 was 32%, 18%, 14%, and 0%, respectively, p = 0.02. With an average follow-up of 48 months, the 5-year MSS (G1: 86% vs G2: 75%, p = 0.002) and the 5-year RFS (G1: 81% vs G2: 60%, p = 0.004) were significantly higher in G1 than G2. Tumor-infiltrating lymphocytes in melanoma are associated with the SLN status and with a better MSS and RFS.
ABSTRACT
Se analizó la epidemiología de la Varicela complicada en pacientes del Hospital Pediátrico Juan Pablo II de laciudad de Corrientes en el periodo 2008 2011, se describió la evolución de los pacientes internados por varicelacomplicada y se la relacionó con el estado nutricional y las internaciones previas de los niños. Estudio descriptivo, retrospectivo, observacional. Población conformada por niños de ambos sexos desde 1 mes a 16 años. Se revisaron las historias clínicas correspondientes. Registramos 1.832 consultas por Varicela (solo en guardia de emergencias) y 75 hospitalizaciones. Hallamos 87% de niños eutróficos, 9% con desnutrición leve, 1% con desnutrición moderada y 3% con desnutrición severa. Solo 18 pacientes con internaciones previas y ningúnpaciente de la serie con inmunización antivaricela. Complicaciones cutáneas: sobreinfección bacteriana, rash,celulitis, impétigo. Otras: neumonía bacteriana, neumonitis, ataxia y encefalitis. El 61% de los internados fueregistrado como primer caso entre los contactos. No hubo óbitos...
We analyzed the epidemiology of varicella in children at Pediatric Hospital Juan Pablo II of Corrientes in 2008-2011. We describe the evolution of patients with complicated chickenpox and related infectious complications withnutritional status and previous hospitalizations. Descriptive, retrospective, observational study. Population composed of children of both sexes from 1 month to 16 years old. We reviewed clinical records; 1.832 consultations by chickenpox (only in emergency service); 75 patients required hospitalization. We associate nutritional status and number of previous internments with complications of the disease, and found 87% of normal children, 9% with mild malnutrition, 1% with moderate malnourished and 3% with severe malnourished. Only 18 had previous hospitalization. None of children with varicella immunization. Cutaneous complications: bacterial superinfection, rash, cellulitis, impetigo. Others: pneumonitis, bacterial pneumonia, ataxia and encephalitis. 61% of cases were registered as the first case between contacts. None of them dead.
