ABSTRACT
Hypoxia is related to poor prognosis because it is associated to chemo- and radioresistance. During recent years the evolution of imaging methods like PET/CT and MRI has meant the appearance of new perspectives with direct implications in radiation therapy. We discuss previous experiences in staging, planning and in the follow-up process with these techniques for measuring tumour hypoxia.
Subject(s)
Hypoxia/metabolism , Molecular Imaging/methods , Neoplasms/radiotherapy , Neoplasms/therapy , Radiotherapy Planning, Computer-Assisted/methods , Animals , Biomarkers, Tumor/genetics , Biomarkers, Tumor/metabolism , Fluorodeoxyglucose F18 , Humans , Hypoxia/genetics , Immunohistochemistry , Neoplasms/diagnosis , Neoplasms/metabolism , Positron-Emission Tomography/methods , Prognosis , Tomography, X-Ray Computed/methodsABSTRACT
The main objective of image-guided radiation therapy (IGRT) equipment is to reduce and correct inherent errors in external radiotherapy processes. At the present time, there are different IGRT systems available, but here we will refer exclusively to the kilovoltage cone-beam CT onboard linear accelerator (CBkVCT) and the different aspects that, from a clinical point of view, should be taken into consideration before the implementation of this equipment.
Subject(s)
Cone-Beam Computed Tomography/instrumentation , Particle Accelerators , Radiotherapy Planning, Computer-Assisted/instrumentation , Cone-Beam Computed Tomography/methods , Models, Theoretical , Radiotherapy Planning, Computer-Assisted/methodsABSTRACT
We present a clinical case of a patient diagnosed with a retroperitoneal sarcoma, which received preoperative treatment with daily verification via computed tomography obtained with kilovoltage cone beam. We compare the benefit of this treatment compared to other conventional treatment without image guiding, reporting quantitative results.