Environmental impact assessment of the electrokinetic adsorption barriers to remove different herbicides from agricultural soils.

In this study, the sustainability of the electrokinetic remediation soil flushing (EKSFs) process integrated without and with adsorption barriers (EKABs) have been evaluated for the treatment of four soils contaminated with Atrazine, Oxyfluorfen, Chlorosulfuron and 2,4-D. To this purpose, the environmental effects of both procedures (EKSFs and EKABs) have been determined through a life cycle assessment (LCA). SimaPro 9.3.0.3 was used as software tool and Ecoinvent 3.3 as data base to carry out the inventory of the equipment of each remediation setup based on experimental measurements. The environmental burden was quantified using the AWARE, USEtox, IPPC, and ReCiPe methods into 3 Endpoint impact categories (and damage to human health, ecosystem and resources) and 7 Midpoints impact categories (water footprint, global warming potential, ozone depletion, human toxicity (cancer and human non-cancer), freshwater ecotoxicity and terrestrial ecotoxicity). In general terms, the energy applied to treatment (using the Spanish energy mix) was the parameter with the greatest influence on the carbon footprint, ozone layer depletion and water footprint accounting for around 70 % of the overall impact contribution. On the other hand, from the point of view of human toxicity and freshwater ecotoxicity of soil treatments with 32 mg kg-1 of the different pesticides, the EKSF treatment is recommended for soils with Chlorosulfuron. In this case, the carbon footprint and water footprint reached values around 0.36 kg of CO2 and 114 L of water per kg of dry soil, respectively. Finally, a sensitivity analysis was performed assuming different scenarios.

Calidad asistencial de la psicología clínica en el Servicio Andaluz de Salud evaluada por los facultativos / Quality of care of Clinical Psychology in the Andalusian Health Service as assessed by professionals

Objetivo: evaluación de la calidad asistencial de los servicios de psicología clínica en el Servicio Andaluz de Salud (SAS) desde la perspectiva de los/as facultativos/as. Método: investigación descriptiva; se elaboró un cuestionario de 39 ítems que evalúa diferentes dimensiones de la calidad asistencial (prevención, accesibilidad, idoneidad de intervenciones de evaluación y tratamiento, seguridad, y coordinación); han participado 83 facultativos/as especialistas de psicología clínica del SAS, lo que supone un 32’17% de la población de referencia en el momento de la recogida de datos.Resultados:la calidad asistencial actual de las prestaciones de psicología clínica en el SAS, partiendo de una ratio de 3,05 facultativos por cada100.000 habitantes, es deficiente, sobre todo en las variables de prevención, intensidad de las intervenciones de tratamiento y seguridad, y especialmente preocupante en los dispositivos del segundo nivel asistencial.Conclusiones: es urgente aumentar el número de profesionales especialistas en psicología clínica por cada 100.000 habitantes para reducir el riesgo que supone para los usuarios la deficiente intensidad con que se practican los tratamientos psicológicos; asimismo, es necesario establecer estándares de la carga de trabajo de los psicólogos clínicos para poder ofrecer una calidad asistencial adecuada, e integrar indicadores medibles de calidad en los sistemas de información de salud mental (AU)

Objective: Evaluation of healthcare quality of clinical psychology services in the Andalusian Health Service (SAS) from the perspective of the facultative. Method: Descriptive research. For data collection, a 39-item questionnaire was developed that assesses various dimensions of quality (prevention, accessibility, suitability of evaluation and treatment interventions, safety, and care coordination). A sample of 83 clinical psychologists responded to the questionnaire, representing 32.17% of the reference population, 258 facultative who, at the time of data collection make up the SAS staff. Results: The current quality of care of clinical psychology services in the SAS, based on a ratio of 3.05 clinical psychologists per 100,000 inhabitants, is deficient, especially in the dimensions of prevention, intensity of treatment interventions, and safety, and worrisome in the 2nd level of care. Conclusions: It is urgent to increase the ratio of clinical psychologists/100,000 inhabitants to reduce the risk posed for users by the deficient intensity with which psychological treatments are currently practiced. It is necessary to esta-blish standards for the workload of clinical psychologists in order to offer an adequate quality of care, and to integrate measurable indicators of quality in mental health information systems (AU)

Hiperpotasemia e hipoaldosteronismo funcional tras adrenalectomía unilateral por hiperaldosteronismo primario en paciente monorreno con insuficiencia renal crónica / Hyperpothemasia and functional hypoaldosteronism after unilateral adrenalectomy for primary hyperaldosteronism in monorrene patient with chronic renal insufficiency

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Allele diversity of the killer cell immunoglobulin-like receptors KIR3DL1/S1 and the combination with their HLA ligands in Mexican Mestizos from Mexico City.

Killer cell immunoglobulin-like receptors (KIRs), expressed on Natural Killer (NK) cells, activate/inhibit NK cell function through interactions with their HLA-A, B and C ligands. KIR3DL1 is one of the most polymorphic genes and its effect varies depending on the interaction of the specific allotype with its Bw4 ligand. We investigated the allelic diversity of KIR3DL1/S1 using sequence based typing and we typed as well, their Bw4 ligands in Mexican Mestizos of Mexico City. The results showed that this population has a great KIR3DL1 allelic diversity with ∗01502 (19.9%), ∗00101 (13.2%) and ∗00501 (12.8%) being the most common alleles, while KIR3DS1 showed predominance of ∗01301 (86%); these data agree with the diversity found in most populations studied. At least one KIR3DL1-HIGH surface expression allele was present in 67.5% of the subjects. Phylogenetic comparisons between Mestizos and 28 different populations showed that allelic diversity of KIR3DL1/S1 was similar in Mexican Mestizos from Mexico and in Hispanics from USA. Knowledge of KIR and MHC diversity worldwide is fundamental for understanding the impact of KIR and KIR-ligand polymorphism on NK cell effector functions and is relevant in genetic anthropology, disease association and transplantation.

Early postnatal genistein administration permanently affects nitrergic and vasopressinergic systems in a sex-specific way.

Genistein (GEN) is a natural xenoestrogen (isoflavonoid) that may interfere with the development of estrogen-sensitive neural circuits. Due to the large and increasing use of soy-based formulas for babies (characterized by a high content of GEN), there are some concerns that this could result in an impairment of some estrogen-sensitive neural circuits and behaviors. In a previous study, we demonstrated that its oral administration to female mice during late pregnancy and early lactation induced a significant decrease of nitric oxide synthase-positive cells in the amygdala of their male offspring. In the present study, we have used a different experimental protocol mimicking, in mice, the direct precocious exposure to GEN. Mice pups of both sexes were fed either with oil, estradiol or GEN from birth to postnatal day 8. Nitric oxide synthase and vasopressin neural systems were analyzed in adult mice. Interestingly, we observed that GEN effect was time specific (when compared to our previous study), sex specific, and not always comparable to the effects of estradiol. This last observation suggests that GEN may act through different intracellular pathways. Present results indicate that the effect of natural xenoestrogens on the development of the brain may be highly variable: a plethora of neuronal circuits may be affected depending on sex, time of exposure, intracellular pathway involved, and target cells. This raises concern on the possible long-term effects of the use of soy-based formulas for babies, which may be currently underestimated.