ABSTRACT
AIMS: There are no antecedents in Cuba of studies developed to prove the efficacy of on allergy test to pollen Parthenium hysterophorus L. OBJECTIVE: Evaluate the allergenic extract pollen Parthenium hysterophorus L elaborated at the reference hospital William Soler City Havana. MATERIAL AND METHODS: We selected 100 patients with a positive clinic history of inhalant allergy and 100 healthy person. All the persons selected were skin prick tested with dillution's of the extract (1:100 and 1:1000 P/V) and positive and negative control. We measured the average diameter of the wheal and the perpendicular diameter, then we calculated the average. We also calculated size of the wheal in the duplicated, which constituted the size of the reaction. We estimated the validity of the test calculating the sensibility and specificity. We used the EPITABLE program to do this. RESULTS: The skin prick tested positive in 79% of the patients and 9% in the healthy persons, for a sensitivity of 79% the interval of confidence (IC), 69.5, 86.2 and specificity of 91%, IC 83.2, 95.5, the predictive positive value 89.8% IC 81.04, 94.9 and the predictive negative value 81.3%, IC 72.5, 87.8. CONCLUSIONS: The allergenic extract of Parthenium hysterophorus L in very sharp to test the allergy to his pollen produced by the allergology laboratory of Hospital William Soler, is efficacy by diagnostic of the alterations caused by this pollen.
Subject(s)
Asteraceae/immunology , Hypersensitivity/diagnosis , Pollen/immunology , Adolescent , Adult , Child , Child, Preschool , Cuba , Female , Humans , Male , Middle Aged , Skin TestsABSTRACT
There are not enough data concerning asthma mortality in Latin America. The Latin American Society of Allergy and Immunology coordinated this project to provide reliable data for gaining knowledge about our present situation, which is a condition indispensable to changing it. The following countries participated in this study: Argentina, Brazil, Chile, Colombia, Costa Rica, Cuba, Mexico, Paraguay, Peru, Uruguay and Venezuela. A uniform protocol was designed in Santa Fe, Argentina. Asthma mortality rates were analyzed in accordance with two variables: age-adjusted rates (5-34) and total death rates. The total population studied was 107, 122, 529 inhabitants. The highest death rates were found in Uruguay and Mexico (5.63), and the lowest in Paraguay (0.8) and Colombia (1.35). Age-adjusted (5-34) rates were higher in Costa Rica (1.38) and lower in Chile (0.28). Regarding sex, the analysis of the information provided by seven countries showed a predominance of females (51.8%) over males (48.18%). In the southern Latin American countries such as Chile, Uruguay, Paraguay and Argentina, which have marked climatic differences, deaths occurred mainly in the winter. It is important to emphasize that, in most countries, deaths from asthma occurred at home: Chile (60.7%), Argentina (63.4%) and Paraguay (88%). However, in Uruguay, 58.6% occurred during hospitalization. Mortality rates from bronchial asthma are high in most of the Latin American countries studied, even though further studies are needed. Asthma is a serious global health problem. People of all ages in countries throughout the world are affected by this chronic airway disorder that can be severe and sometimes fatal. The health ministries of each country do not believe asthma is a significant issue. Therefore, we should provide them with sound epidemiological studies to convince them to change their attitude toward this disease.
Subject(s)
Asthma/mortality , Adolescent , Adult , Age Factors , Aged , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Latin America/epidemiology , Male , Middle Aged , Sex FactorsABSTRACT
Se hicieron pruebas cutáneas a 201 pacientes (niños) con evidencias clínicas de alergia al polvo, con la utilización de 2 extractos acuosos del ácaro Dermatophagoides siboney (1:10 000 y 1:1 000), el extracto comercial de D farinae (1:10 000), 5 de hongos (Aspergillus, Penicillium, Rhizopus, Cladosporium y Alternaria), uno de polvo doméstico (1:50 000) y un control. Mostraron reacciones positivas 137 pacientes al extracto 1:1 000 y 113 al 1:10 000 de D. Siboney; 165 lo hicieron al extracto de D. farinae y 164 al polvo doméstico. Las reacciones por hongos fueron escasas. Tanto la prueba de X a la 2, para la positividad, como la prueba de la t de Student, para la reacción, no mostraron diferencias significativas para p < 0,95, entre los resultados obtenidos en los extractos de D. siboney 1:10 000, D. farinae 1:10 000, por lo que pudieran ser utilizados indistintamente, al tener en cuenta la diferencia de concentración
Subject(s)
Child, Preschool , Child , Adolescent , Humans , Male , Female , Allergens , Mites , Skin TestsABSTRACT
Se hicieron pruebas cutáneas a 201 pacientes (niños) con evidencias clínicas de alergia al polvo, con la utilización de 2 extractos acuosos del ácaro Dermatophagoides siboney (1:10 000 y 1:1 000), el extracto comercial de D farinae (1:10 000), 5 de hongos (Aspergillus, Penicillium, Rhizopus, Cladosporium y Alternaria), uno de polvo doméstico (1:50 000) y un control. Mostraron reacciones positivas 137 pacientes al extracto 1:1 000 y 113 al 1:10 000 de D. Siboney; 165 lo hicieron al extracto de D. farinae y 164 al polvo doméstico. Las reacciones por hongos fueron escasas. Tanto la prueba de X a la 2, para la positividad, como la prueba de la t de Student, para la reacción, no mostraron diferencias significativas para p < 0,95, entre los resultados obtenidos en los extractos de D. siboney 1:10 000, D. farinae 1:10 000, por lo que pudieran ser utilizados indistintamente, al tener en cuenta la diferencia de concentración
Subject(s)
Child, Preschool , Child , Adolescent , Humans , Male , Female , Skin Tests , Allergens , AcaridaeABSTRACT
A survey of bronchial asthma prevalence and inheritance patterns was carried out in the municipality of San Antonio de los Banõs, La Habana, Cuba, employing as a sample 3,295 of the area's inhabitants. These persons, selected by stratified, non-restricted sampling techniques, represented 11.02 per cent of the total population. The asthma prevalence found in this sample, which was considered representative of the local population, was 9.74 percent. No significant variations were noted in male and female prevalence rates. The occurrence of bronchial asthma is strongly influenced by inheritance. Our survey supported this view, and also showed that the age of asthma onset is influenced by whether or not the subject's family has a positive history of allergy or not. However, patients with a positive history on one side of their family had an age of onset that was not significantly different from patients with a positive history on both sides (p less than 0.35). Overall, the results tend to confirm that the inheritance of bronchial asthma is autosomal and does not conform to simple dominant or recessive inheritance patterns. Rather, asthma inheritance appears multifactorial, perhaps involving varying degrees of expression, indicating that more is involved than absence or deficiency of a single enzyme.
Subject(s)
Asthma/epidemiology , Adolescent , Adult , Asthma/genetics , Child , Child, Preschool , Cuba , Demography , Female , Humans , Infant , Male , Sampling StudiesABSTRACT
A survey of bronchial asthma prevalence and inheritance patterns was carried out in the municipality of San Antonio de los Banâs, La Habana, Cuba, employing as a sample 3,295 of the area's inhabitants. These persons, selected by stratified, non-restricted sampling techniques, represented 11.02 per cent of the total population. The asthma prevalence found in this sample, which was considered representative of the local population, was 9.74 percent. No significant variations were noted in male and female prevalence rates. The occurrence of bronchial asthma is strongly influenced by inheritance. Our survey supported this view, and also showed that the age of asthma onset is influenced by whether or not the subject's family has a positive history of allergy or not. However, patients with a positive history on one side of their family had an age of onset that was not significantly different from patients with a positive history on both sides (p less than 0.35). Overall, the results tend to confirm that the inheritance of bronchial asthma is autosomal and does not conform to simple dominant or recessive inheritance patterns. Rather, asthma inheritance appears multifactorial, perhaps involving varying degrees of expression, indicating that more is involved than absence or deficiency of a single enzyme (Au)
