[Clinical effect of a sustained-release theophylline formulation in moderate or severe asthmatic patients with intercrisis]. / Efecto clínico de una formulación de teofilina de liberación sostenida en pacientes asmáticos moderados o severos con intercrisis.

The clinical effect of the formulation of theophylline of sustained action was evaluated (Aristegui 300 mg, capsules) to the dose of 9 weight/day mg/kg (every 12 hours) in the consultation of bronchial asthma of Hospital Docente Provincial Clínico Quirúrgico de Santa Clara, in the understood period of February to September of 1997. The time of treatment was of one month and they were carried out five consultations. The sample was constituted by 30 asthmatic, moderate or severe patients. The variables were analyzed: attendance to guard's body, salbutamol use in spray and they were carried out objective mensurations from the lung function to all the patients in the different consultations. With the use of the formulation they diminished the flow expiratory pick significantly, the expiratory volume forced in one second and the flow half expiratory maximum and low incidence of adverse effects existed.

[Total serum IgE values in two different populations of asthmatics with different levels of environmental contamination]. / Valores de IgE sérica total en asmáticos de dos poblaciones con diferentes niveles de contaminación ambiental.

A group of asthmatic patients with an average age between 15 to 50 years were followed at the Allergology Service of Teaching Hospitals from Santa Clara and Sagua la Grande, respectively. For the diagnosis, clinical and espirometric criteria were taken into account; the sample consisted of 100 patients living in Sagua; this part is considered to be a very polluted area, and the same amount of patients from Santa Clara City. The seric figures of total IgE were quantified and a survey was applied to value its relationship with other polluting substances and other clinical and epidemiological aspects of bronchial asthma. The number of patients from Sagua with high levels of IgE was relevant, this could be influenced by the high levels of polluting substances which act as inhaler or irritant substances.