ABSTRACT
El objetivo del presente estudio fue determinar si la depresión antecede al deterioro cognitivo leve (DCL) como factor de riesgo o como predictor en la enfermedad de Alzheimer (EA). Se realizó una revisión sistemática de estudios observacionales (transversales y de cohorte o seguimiento) mediante el algoritmo de búsqueda PRISMA, de los marcadores clínicos en DCL y EA, en las bases de datos Science Direct, Springer, Scopus y Proquest. Los criterios de elegibilidad del estudio incluyeron como criterios inclusión: tipos de documentos, artículos de estudios primarios; tipo de fuente, revistas científicas, en idioma inglés, desde enero de 2010 hasta abril de 2020, en pacientes con DCL y EA y en el grupo de edad comprendido en personas con un rango de edad mínimo de 45años. Los criterios de exclusión fueron: las publicaciones de más de 10años (el objetivo del artículo era explorar estudios recientes), estudios de investigación secundaria, tipo de documento de informe, otros idiomas diferentes al inglés. Se identificaron 3.385 artículos, de los que finalmente se seleccionaron 30 artículos. Se encontró que existe una asociación entre la depresión y la EA, pero propiamente como un factor de riesgo, mas no como un predictor o marcador clínico del desarrollo de la EA. El grado de asociación es mayor cuando presentan sintomatología depresiva y simultáneamente reportan quejas de memoria subjetiva o la presencia de DCL. (AU)
The objective of the present study was to determine whether depression precedes Mild cognitive impairment (MCI) as a risk factor or as a predictor in Alzheimer's disease (AD). A systematic review of observational studies (cross-sectional and cohort or follow-up) was carried out using the PRISMA search algorithm, for clinical markers in MCI and AD, in the Science Direct, Springer, Scopus and Proquest databases. The study eligibility criteria included inclusion criteria: of types of documents, articles of primary studies, type of source scientific journals, published in the English language, from January 2010 to April 2020, in patients with MCI and AD and in the group of age included in people with a minimum age range of 45years. Exclusion criteria were: publications older than 10years because the aim of the article was to explore recent studies, secondary research studies, type of report document, languages other than English. 3385 articles were identified, of which 30 articles were finally selected. It was found that there is an association between depression and AD, but properly as a risk factor but not, as a predictor or clinical marker of the development of AD. The degree of association is greater when they present depressive symptoms and simultaneously report subjective memory complaints or the presence of MCI. (AU)
Subject(s)
Humans , Middle Aged , Aged , Aged, 80 and over , Cognitive Dysfunction , Depression , Alzheimer Disease , Cross-Sectional Studies , Follow-Up Studies , Databases, BibliographicABSTRACT
The objective of the present study was to determine whether depression precedes Mild cognitive impairment (MCI) as a risk factor or as a predictor in Alzheimer's disease (AD). A systematic review of observational studies (cross-sectional and cohort or follow-up) was carried out using the PRISMA search algorithm, for clinical markers in MCI and AD, in the Science Direct, Springer, Scopus and Proquest databases. The study eligibility criteria included inclusion criteria: of types of documents, articles of primary studies, type of source scientific journals, published in the English language, from January 2010 to April 2020, in patients with MCI and AD and in the group of age included in people with a minimum age range of 45years. Exclusion criteria were: publications older than 10years because the aim of the article was to explore recent studies, secondary research studies, type of report document, languages other than English. 3385 articles were identified, of which 30 articles were finally selected. It was found that there is an association between depression and AD, but properly as a risk factor but not, as a predictor or clinical marker of the development of AD. The degree of association is greater when they present depressive symptoms and simultaneously report subjective memory complaints or the presence of MCI.
