Is the Cis-Element CACCC-Box a Master Regulatory Element during Cardiovascular Disease? A Bioinformatics Approach from the Perspective of the Krüppel-like Family of Transcription Factors.

The CACCC-box motif emerges as a pivotal cis-regulatory element implicated in diverse developmental processes and diseases, particularly cardiovascular diseases (CVDs). This study centers on the intricate interplay between the CACCC-box and its binding proteins such as: the Krüppel-Like Family (KLF) of transcription factors as primary effectors in the context of CVDs. Our analysis was through a bioinformatics approach, which revealed significant transcriptional activity among KLF subgroup 2, exhibiting the highest number of interactions focusing on the established roles: pluripotency, cancer, and cardiovascular development and diseases. Our analysis reveals KLF's interactions with GATA4, MEF2C, NKX2.5 and other ~90 potential genes that participate in the regulation of the hypertrophic environment (or CVDs' Environment). Also, the GO analysis showed that genes containing the motif CACCC were enriched for multiple CVDs; in combination with STRING analysis, these results pointed to a link between KLFs and these diseases. The analysis further identifies other potential CACCC-box binding factors, such as SP family members, WT1, VEZF1, and -SALL4, which are implicated in cardiac contraction, remodeling, and inflammation processes.

Parto instrumental y cesárea en gestantes adolescentes / Instrumental delivery and cesarean in adolescent gestants

Se realizó un estudio prospectivo que incluyo 694 gestantes adolescentes con la finalidad de comparar la incidencia de parto instrumental y cesárea entre las jóvenes de 12 a 15 años (82 casos, grupo No 1) y las de 16 a 19 años (612 casos, grupo No 2). las adolescentes representaron el 22.6 por ciento de los casos obstetricos atendidos en el Hospital Universitario de Caracas en 1994. En el grupo No. 1 encontramos 13.6 por ciento de forceps: 63.6 por ciento por agotamiento materno y 18.2 por ciento: terminaron en cesárea 17.3 por ciento: por desproporción fetopélvica,28.6 por ciento, por sufrimiento fetal 28.6 por ciento y por presentación podálica 21.4 por ciento. En el grupo No. 2 hallamos 12.8 por ciento de forceps: 23.9 por ciento fué profiláctico y 19.7 por ciento debido a sufrimiento fetal: la frecuencia de cesárea fué de 15.5 por ciento por desproporción fetopélvica, 41.9 por ciento y por sufrimiento fetal 24.4 por ciento. No se hallo diferencia estadísticamente significativa en cuanto a la incidencia de parto instrumental y cesárea entre ambos grupos etarios