ABSTRACT
AIMS: Laryngeal carcinoma is a common upper respiratory tract cancer with different environmental and genetic factors involved in its development. To date, CAPN10 has been found to be extensively associated with hyperinsulinaemia and type 2 diabetes mellitus, by different groups. In addition, some reports have shown evidence that hyperinsulinaemia exerts a protective effect on laryngeal cancer risk. On the other hand, low circulating levels of IGF-1 have been recently found in patients with laryngeal carcinoma. Our objective was to examine the contribution of CAPN10 alleles to the development of laryngeal cancer. METHODS: Cases and controls were recruited from central and southern Spain. Genotypes were determined using pyrosequencing technology. We analysed CAPN10 UCSNP-44, -43, -19, and -63 allelic distribution in 218 unrelated laryngeal cancer patients and 606 controls from the general population. RESULTS: We found that the UCSNP-44 allele-C is significantly under-represented among patients with laryngeal cancer (OR=0.685, p=0.02). CONCLUSION: These results indicate that some CAPN10 alleles may be exerting a protective effect on laryngeal cancer risk in the Spanish population.
Subject(s)
Calpain/genetics , Laryngeal Neoplasms/enzymology , Laryngeal Neoplasms/genetics , White People/genetics , Alleles , Case-Control Studies , Female , Haplotypes , Humans , Male , Middle Aged , Risk Factors , SpainABSTRACT
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Subject(s)
Male , Child , Humans , Tonsillectomy/adverse effects , Tonsillectomy/methods , Hemorrhage/complications , Hemorrhage/diagnosis , Hemorrhage/surgery , Ligation/methods , Carotid Artery, External/surgery , Ambulatory Surgical Procedures/methods , Ambulatory Surgical Procedures/statistics & numerical data , Angiography/methods , Amygdala/pathology , Amygdala/surgery , Amygdala , Hospitalization/statistics & numerical data , Hospitalization/trends , Hematemesis/complications , Hematemesis/diagnosis , Colonoscopy/methodsABSTRACT
La lepra es una enfermedad crónica producida por M. leprae cuya afectación mucosa más relevante se produce a nivel de la región nasal, con destrucción importante de la zona, dando lugar a la típica facies leonina. Presentamos el caso de una paciente con lepra nasal, señalando las características clínicas más importantes, así como el procedimiento diagnóstico y terapéutico al que fue sometida (AU)
The leprosy is a chronic illness caused by M. leprae, which affects mucosa mainly at the level of the nasal region. The important destruction of the bone produces the facies leonina. We present the case of a patient with nasal leprosy, describing the clinical characteristics and the diagnostic and therapeutic methods that were carried out on her (AU)
Subject(s)
Humans , Female , Middle Aged , Leprosy/diagnosis , Pigmentation Disorders/etiology , Cartilage Diseases/etiology , Nose Diseases/etiology , Face , Nasal SeptumABSTRACT
The leprosy is a chronic illness caused by M. leprae, which affects mucosa mainly at the level of the nasal region. The important destruction of the bone produces the facies leonina. We present the case of a patient with nasal leprosy, describing the clinical characteristics and the diagnostic and therapeutic methods that were carried out on her.
