ABSTRACT
Introducción y objetivo: Nuestro objetivo es analizar la incidencia de tuberculosis (TB) en nuestra población y comparar las características de los pacientes con y sin infección por VIH (I-VIH). Pacientes y métodos: Estudio clínico-epidemiológico de cohortes retrospectivo. Se incluyeron pacientes diagnosticados de TB con y sin I-VIH entre los años 2005-2016 en la provincia de Guadalajara (España). Se analizaron variables epidemiológicas, clínicas, microbiológicas y terapéuticas, incluyendo las resistencias microbiológicas. Resultados: Se realizaron 261 diagnósticos de TB. Hubo 25 pacientes (9,6%) que presentaban I-VIH, los cuales eran predominantemente varones, tenían una mayor incidencia de virus de la hepatitis C, mayor porcentaje de afectación extrapulmonar, una mayor prevalencia de resistencia a la isoniacida y a la rifampicina así como una mayor respuesta paradójica y estancia media más prolongada. Por otra parte, presentaron menor porcentaje de prueba de tuberculina positiva y de baciloscopias en esputo positivas. Un porcentaje significativo de pacientes con TB no tenían realizada una serología para VIH. Conclusión: Los pacientes con I-VIH muestran notables diferencias en variables epidemiológicas, clínicas y de resistencia a los fármacos antituberculosos. En un porcentaje elevado de pacientes con TB se desconoce su serología para VIH
Background and objective: Our objective is to analyze the incidence of tuberculosis (TB) in our population and to compare the characteristics of patients with and without HIV infection. Patients and methods: Clinical-epidemiological retrospective cohort study that included patients diagnosed with TB with and without HIV infection between 2005-2016 in the province of Guadalajara (Spain). Epidemiological, clinical, microbiological and therapeutic variables were assessed, including microbiological resistances. Results: TB was diagnosed in 261 patients. There were 25 patients (9.6%) who had HIV infection. Patients with HIV infection were predominantly males, had higher incidence of hepatitis C virus, a higher percentage of extrapulmonary TB, a higher prevalence of resistance to isoniazid and rifampicin, a greater paradoxical response and a longer average hospital stay. On the other hand, they had a lower percentage of positive tuberculin skin test and positive sputum smear (microscopy). A significant percentage of TB patients had no serology for HIV. Conclusion: Patients with HIV infection show remarkable differences in epidemiological, clinical and resistance variables to antituberculosis drugs. A high percentage of patients with TB were not tested for HIV
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Tuberculosis/epidemiology , Tuberculosis/microbiology , HIV Infections/complications , Tuberculosis/drug therapy , Cohort Studies , Retrospective Studies , Spain/epidemiology , Antitubercular Agents , Tuberculosis, Multidrug-ResistantABSTRACT
BACKGROUND AND OBJECTIVE: Our objective is to analyze the incidence of tuberculosis (TB) in our population and to compare the characteristics of patients with and without HIV infection. PATIENTS AND METHODS: Clinical-epidemiological retrospective cohort study that included patients diagnosed with TB with and without HIV infection between 2005-2016 in the province of Guadalajara (Spain). Epidemiological, clinical, microbiological and therapeutic variables were assessed, including microbiological resistances. RESULTS: TB was diagnosed in 261 patients. There were 25 patients (9.6%) who had HIV infection. Patients with HIV infection were predominantly males, had higher incidence of hepatitis C virus, a higher percentage of extrapulmonary TB, a higher prevalence of resistance to isoniazid and rifampicin, a greater paradoxical response and a longer average hospital stay. On the other hand, they had a lower percentage of positive tuberculin skin test and positive sputum smear (microscopy). A significant percentage of TB patients had no serology for HIV. CONCLUSION: Patients with HIV infection show remarkable differences in epidemiological, clinical and resistance variables to antituberculosis drugs. A high percentage of patients with TB were not tested for HIV.
Subject(s)
Tuberculosis/epidemiology , Adult , Cohort Studies , Female , HIV Infections/complications , Humans , Incidence , Male , Middle Aged , Retrospective Studies , Tuberculosis/complications , Tuberculosis/diagnosis , Tuberculosis/drug therapyABSTRACT
No disponible
Subject(s)
Male , Infant , Humans , Lymphadenitis/microbiology , Mycobacterium/pathogenicity , Mycobacterium Infections/microbiology , Communicable Diseases, Emerging/microbiologySubject(s)
Acanthamoeba Keratitis/etiology , Acanthamoeba/isolation & purification , Contact Lens Solutions/adverse effects , Contact Lenses, Hydrophilic/adverse effects , Acanthamoeba Keratitis/diagnosis , Acanthamoeba Keratitis/drug therapy , Adolescent , Animals , Corneal Opacity/etiology , Drug Contamination , Equipment Contamination , Fungi/isolation & purification , Gram-Negative Bacteria/isolation & purification , Humans , MaleABSTRACT
No disponible
