1.
RSC Adv
; 11(50): 31373-31376, 2021 Sep 21.
Article
in English
| MEDLINE
| ID: mdl-35496844
ABSTRACT
Remdesivir is an antiviral nucleoside phosphoramidate with activity against multiple viruses, including SARS-CoV-2. To enable studies of viral polymerases with RNA containing remdesivir, we report an efficient synthesis of a phosphoramidite of GS-441524, the nucleoside precursor of remdesivir, and its incorporation into RNA using automated solid-phase RNA synthesis.