[Cytological aspects of therapeutic pathomorphism of lung squamous cell carcinoma during intratumor chemotherapy].

The paper shows the rate of pathomorphism, by comparing the major cytometrical indices of squamous-cell cancer of the lung before and after single-stage intratumoral chemotherapy on the basis of studies of puncture and intraoperative specimens from 13 patients. Morphometry of 1950 relatively preserved tumor cells was made. The degree of intratumor chemotherapeutic action on tumor cells was objectively reflected in a significant difference in the mean values of the area of the cytoplasm (from 325.1 +/- 7.52 microm2 in the puncture specimens before administration of chemicals to 426.2 +/- 12.67 microm2 in the intraoperative specimens after their administration) and nuclei (from 127.9 +/- 3.45 to 179.7 +/- 7.86 microm2) and in the nuclear shape ratio (from 1.32 +/- 0.02 to 1.48 +/- 0.02).

[Cytologic diagnosis of hepatic tumors by examining puncture bioptates].

Data on cytological diagnosis of hepatic tumors (1996-2006) are evaluated. The potential of cytological examination for identification of the biological mechanism and histological pattern of such malignancies were demonstrated. Cytological examination of puncture bioptates established such diagnostic features as sensitivity (90%), specificity (88%), and effectiveness (89%) as well as prognostic significance of positive (99%) and negative (41%) results.

[Application of the puncture biopsy in diagnosis of malignant tumors of suprarenal glands]. / Primenenie punktsionnoi biopsii v diagnostike zlokachestvennykh opukholei nadpochechnikov.

Possibilities of application of the fine-needle aspiration puncture biopsy (FNAPB) in diagnosis of suprarenal glands tumors were studied. Of 43 patients, to whom FNAPB was performed, in 27 the suprarenal gland tumor was diagnosed, in 11--renal tumor, in 5--the puncture biopsy material occurred noninformative. Of 27 patients with tumor of suprarenal gland in 15 it was malignant, in 11--benign adenoma and cyst of suprarenal gland were revealed. FNAPB of the suprarenal gland tumor is a safe, informative and in some situations curative method. FNAPB is recommended for diagnosis of primarily revealed tumors of suprarenal glands more than 2 cm in diameter. The procedure should be performed by specially trained physician, who determines technical conditions of its conduction by himself and possesses the method o fultrasonography. Data of cytological investigationspermits to differentiate benign and malignant tumor, to determine the tumor type, what constitutes diagnostic background for the tactic choice of surgical intervention and the disease prognosis.

[The puncture cytological diagnosis of neoplasms of the mediastinum (11 years of experience)]. / Punktsionnaia tsitologicheskaia diagnostika novoobrazovanii sredosteniia (11-letnii opyt).

Routinely stained cytological preparations of puncture biopsy specimens of mediastinal tumors from 870 patients are examined. Diagnostically informative material is investigated in 759 (87.3%) cases; malignant tumors are diagnosed in 538 (62%) cases, benign in 221 (25.2%). In 59 (6.8%) cases the cytological answers were descriptive, and in 52 (6%) puncture biopsy material was not informative for cytological verification. Diagnostic sensitivity of the cytological method is 94%, diagnostic specificity 71%, and diagnostic efficacy 91%.

[Effectiveness of transthoracic puncture in the diagnosis and treatment of neoplasms of chest organs]. / Effektivnost' transtorakal'noi punktsii v diagnostike i lechenii novoobrazovanii organov grudnoi kletki.

A complex examination of 1400 patients with pathologies of the lungs and mediastinum was carried out using roentgenologic, endoscopic, bioptic and cytologic methods. Diagnosis was confirmed morphologically in 93.7% of cases. More specific information was obtained by express cytologic examination in 97.9% of cases of malignant growth and in 64.4% with benign tumors. On the basis of the test results, preoperative intratumor chemotherapy technique suggested by the authors may be recommended for clinical use.

[Effectiveness of transthoracic puncture in the diagnosis and treatment of lung cancer]. / Effectivnost transtorakalnoi punktsii v diagnostike i lechenii raka lëgkogo.

The complex examination of 1400 patients with pathologic masses of the lungs and mediastinal organs with the use of roentgenologic, endoscopic, puncture bioptic and cytologic methods was carried out. Morphologic verification of diagnosis was performed in 93.7% of the patients. In express cytologic study, histogenesis of neoplasms of the thoracic cavity organs was specified in 97.9% of cases of a malignant tumour, and in 64.4% of those of a benign one.

[Cytological diagnosis of thoracic tumors in roentgenological and surgical departments]. / Tsitologicheskaia diagnostika pri opukholiakh grudnoi polosti v rentgenokhirurgicheskom kabinete.

Cytologic studies of the material from pulmonary and mediastinal tumors, carried out at a room for x-ray-and-surgery and contrast methods of examination have recognized the type of pulmonary tumors in 96% of cases and of mediastinal tumors in 93.3% of cases. The histologic type of pulmonary tumors has been identified in 82% and of mediastinal tumors in 72% of cases. The method for urgent cytologic diagnosis improves the efficacy of morphologic verification of thoracic tumors before specific treatment.