1.
J Pharm Sci
; 69(10): 1232-4, 1980 Oct.
Article
in English
| MEDLINE
| ID: mdl-7420301
ABSTRACT
Ten 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates were synthesized and evaluated for antitumor activity. The 2-phenoxyethyl ester exhibited activity against P-388 lymphocytic leukemia, and the n-butyl and n-pentyl esters exhibited activity against L-1210 lymphoid leukemia in initial screening tests.
Subject(s)
Antineoplastic Agents/chemical synthesis , Chlorambucil/analogs & derivatives , Animals , Antineoplastic Agents/pharmacology , Chemical Phenomena , Chemistry , Chlorambucil/chemical synthesis , Chlorambucil/pharmacology , Chlorambucil/therapeutic use , Leukemia L1210/drug therapy , Leukemia P388/drug therapy , Leukemia, Experimental/drug therapy , Neoplasms, Experimental/drug therapy
2.
J Pharm Sci
; 69(10): 1332-4, 1980 Oct.
Article
in English
| MEDLINE
| ID: mdl-21618215
ABSTRACT
Ten 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrates were synthesized and evaluated for antitumor activity. The 2-phenoxyethyl ester exhibited activity against P-388 lymphocytic leukemia, and the n-butyl and n-pentyl esters exhibited activity against L-1210 lymphoid leukemia in initial screening tests.
3.
J Pharm Sci
; 63(9): 1487-9, 1974 Sep.
Article
in English
| MEDLINE
| ID: mdl-4427280
Subject(s)
Antineoplastic Agents/chemical synthesis , Nitrogen Mustard Compounds/chemical synthesis , Amides/chemical synthesis , Amides/therapeutic use , Animals , Antineoplastic Agents/therapeutic use , Butyrates/chemical synthesis , Butyrates/therapeutic use , Carcinoma , Carcinoma 256, Walker/drug therapy , Cell Line , Humans , Leukemia L1210/drug therapy , Leukemia, Experimental/drug therapy , Mouth Neoplasms , Nitrogen Mustard Compounds/therapeutic use , Spectrophotometry, Infrared
4.
J Pharm Sci
; 59(6): 861-3, 1970 Jun.
Article
in English
| MEDLINE
| ID: mdl-5423097
