ABSTRACT
BACKGROUND AND METHODS: In six hydrocephalic foetuses (gestational age 29-38 wk), proton MR spectroscopy (1H-MRS) was performed in the basal ganglia for detection of lactate in vivo. RESULTS: Lactate was present in two foetal brains, absent in two and not detectable because of movement in two. CONCLUSION: With adequate immobilization of the foetus, 1H-MRS can be used for detection of foetal brain lactate.
Subject(s)
Brain/metabolism , Fetus/metabolism , Lactic Acid/analysis , Brain/embryology , Female , Gestational Age , Humans , Hydrocephalus/metabolism , Magnetic Resonance Imaging , Magnetic Resonance Spectroscopy , PregnancyABSTRACT
In the present study, we compared brain development and metabolism of small-for-gestational-age (SGA) and appropriate-for-gestational-age (AGA) infants using proton magnetic resonance spectroscopy ((1)H-MRS). We tested the hypothesis that intrauterine growth retardation caused by placental insufficiency is associated with changes in cerebral metabolism and is followed by an adverse neurodevelopmental outcome at the age of 2 y. Twenty-six AGA and 14 SGA (birth weight
