1.
Arzneimittelforschung
; 28(4): 586-94, 1978.
Article
in English
| MEDLINE
| ID: mdl-581933
ABSTRACT
A series of alkyl-(5-acyl-1-H-benzimidazol-2-yl)-carbamates were prepared and screened for anthelminthic activity. Some of them were found to be fully active at low, atoxic oral dose levels against gastro-intestinal nematodes. The activity against Symphacia muria and Strongyloides ratta is indicated. From these studies methyl (5-benzoyl-1-H-benzimidazol-2-yl) carbamate (mebendazole) and methyl [5-(4-flourobenzoyl)-1-H-benzimiazol-2 yl]carbamate flubendazole) were selected for detailed investigation.
Subject(s)
Anthelmintics/chemical synthesis , Benzimidazoles/chemical synthesis , Animals , Anthelmintics/therapeutic use , Benzimidazoles/pharmacology , Benzimidazoles/therapeutic use , Male , Methods , Oxyuriasis/drug therapy , Oxyuroidea , Rats , Strongyloidiasis/drug therapy , Structure-Activity Relationship
2.
Tetrahedron Lett
; 16: 1467-70, 1967 Apr.
Article
in English
| MEDLINE
| ID: mdl-6042549