ABSTRACT
In 20- and 40-day rat studies the prophylactic effect of retabolil and calcitrin (calcitonin) against hypodynamics-induced osteoporosis was investigated. Hypodynamics was produced by surgical amputation of the lower third of the leg and hence by loss of the support function of the limb. Retabolil was injected intramuscularly at a dose of 0.2 ml once a day for 10 days and calcitrin was injected subcutaneously at a dose of 2 units MRC in 0.5 ml distilled water once a day. The results indicate that osteoporosis in the supportless bone of the experimental animals and that seen during space flight developed in a similar way. In the experiment retabolil and calcitrin inhibited the progressive development of osteoporosis but the strongest effect was obtained upon a combined application of the two drugs.
Subject(s)
Calcitonin/therapeutic use , Nandrolone/analogs & derivatives , Osteoporosis/drug therapy , Amputation, Surgical , Animals , Bone and Bones/analysis , Bone and Bones/drug effects , Drug Evaluation, Preclinical , Microradiography , Minerals/analysis , Nandrolone/therapeutic use , Nandrolone Decanoate , Osteoporosis/etiology , Osteoporosis/metabolism , Rats , Restraint, Physical , Time Factors , Weightlessness/adverse effectsABSTRACT
The authors showed a pronounced and stable decrease in sexual motivation of male rats immediately after gamma-irradiation of the head with a dose of 2.58 C/kg. Exposure of the body to 1.29-2.58 C/kg radiation also inhibited sexual behaviour but only by the 45th-55th minute following irradiation: with higher doses some increase in sexual activity was observed immediately after irradiation.
Subject(s)
Sexual Behavior, Animal/radiation effects , Animals , Dose-Response Relationship, Radiation , Gamma Rays , Male , Rats , Time FactorsABSTRACT
Bones of rats flown for 19 days onboard Cosmos-1129 were examined. The examination included bone mass, density, mineral composition, reconstruction parameters, and elemental composition at R + 1, R + 6, and R + 29. After flight the rats developed osteoporosis in the spongy structures of tubular bones and a smaller thickness of the cortical layer of the diaphysis; they showed no mineralization of the microstructures, a slight decrease of the Ca concentration, and a normal content of P. At R + 6 these changes progressively developed and at R + 29 they returned to normal.
Subject(s)
Bone and Bones/pathology , Osteoporosis/etiology , Space Flight , Animals , Bone and Bones/metabolism , Calcium/metabolism , Gravitation , Osteoporosis/pathology , Phosphorus/metabolism , Rats , Rats, Inbred Strains , Time Factors , Weightlessness/adverse effectsABSTRACT
The effect of exercise and diet supplemented with vitamins and trace elements on the reproductive function of white rats exposed to 3-day hypokinesia was studied. Hypokinetic females in a regular diet produced offspring in 33% and those on an enriched diet in 50% cases. The same values were obtained in exercising rats, the time allowed for their exercises making 3% of the total experimental time. A combined use of an enriched diet and exercises resulted in a 100% increase of pupping events.
