ABSTRACT
Acute methanol intoxications are infrequent among accidental or suicidal intoxications today. The characteristic findings are illustrated by a review. Mainly, the methanol metabolites formaldehyde and formic acid are of toxicologic importance and cause the dominant central nervous and ocular symptoms. The principal therapeutic procedures include gastric lavage, induced vomiting, titrated correction of acidosis with sodium bicarbonate, administration of ethanol, folic acid and, especially, the secondary detoxication with peritoneal--or better--haemodialysis. The therapeutic measures must be started quickly and carried out consequently to improve the prognosis of methanol intoxication and to decrease the frequency of serious late complications like ophthalmologic and neurologic lesions. Our own medical management is described by a case report treated successfully.
Subject(s)
Methanol/poisoning , Suicide, Attempted , Adult , Humans , Male , Poisoning/pathologyABSTRACT
In a case report the rare nail-patella-syndrome is presented. Typical and pathognomonic signs are: nail aplasia or dystrophy, iliac horns, hypoplasia or aplasia of the patellae, elbow dysplasia and a nephropathy with electron microscopic demonstrable collagen-like deposition in the glomerular basal membrane. The clinical relevance is determined by the course of the renal disease.
Subject(s)
Kidney Failure, Chronic/diagnosis , Nail-Patella Syndrome/diagnosis , Adult , Biopsy , Collagen/metabolism , Female , Humans , Hypertension, Renal/diagnosis , Kidney/pathology , Microscopy, Electron , Nail-Patella Syndrome/geneticsABSTRACT
Nephrological emergencies are occurrences which may cause acute renal failure by various reasons. Useful support in diagnosis and introduction of treatment offers a classification in prerenal, renal and postrenal etiologic categories in which the prerenal type is most more frequent than the two others. Mitigated courses without decrease in urinary production are now observed increasingly. The clinical term acute emergency indicating a situation immediately life threatening refers in nephrology especially to pulmonary edema, hyperkalemia and hypertensive crisis respectively. Their life saving treatments are described.
Subject(s)
Acute Kidney Injury/etiology , Emergencies , Acute Kidney Injury/therapy , Diagnostic Imaging , Humans , Kidney Function TestsABSTRACT
The antihypoxic activity of tisochromid is compared with the well-known restituting effect of piracetam on posthypoxic dopamine release inhibition. In addition to a distinct restituting effect which accelerates the normalization of dopamine release highly, tisochromid exhibits obviously an antioxidative potency which is responsible for a greater effectiveness of the drug when given prehypoxically. Therefore, tisochromid acts simultaneously as a protective and a restituting drug.
