Subject(s)
Arteriosclerosis/pathology , Carotid Arteries/pathology , Diabetic Angiopathies/diagnostic imaging , Diabetic Angiopathies/pathology , Tunica Intima/pathology , Tunica Media/pathology , Arteriosclerosis/diagnostic imaging , Carotid Arteries/diagnostic imaging , Humans , Lipids/blood , Risk Assessment , Tunica Intima/diagnostic imaging , Tunica Media/diagnostic imaging , UltrasonographyABSTRACT
A case of a 26-year-old patient with acute myocardial infarction and hypertension, hyperlipidaemia as well as type 1 diabetes from 18 years complicated by background retinopathy and nephropathy in the state of proteinuria is described. State of metabolic compensation of the diabetes was poor. The patient did not perform regular self-monitoring of glycaemia, smoked, and used oral contraception. Early diagnosis of vascular lesions in young persons with long-lasting of type 1 diabetes as well as the introduction of proper preventive and treatment methods may improve prognosis in these high-risk patients.
Subject(s)
Diabetes Mellitus, Type 1/complications , Myocardial Infarction/etiology , Adult , Diabetic Nephropathies/etiology , Diabetic Retinopathy/etiology , Female , Humans , Hyperlipidemias/complications , Hypertension/complications , Risk FactorsABSTRACT
Cardiovascular complications are the leading cause of increasing and premature mortality in diabetic patients. Matrix metalloproteinases (MMPs) play an important role in the development and progression of vascular lesions. Matrix metalloproteinases are members of endopeptidases and are capable of degrading many extracellular matrix components. Results of recent studies indicated that non-pharmacological and pharmacological treatment of diabetes influenced disturbed system of metalloproteinases and their inhibitors. Clinical trials are being performed in hope that the selective MMP inhibitors reduce the progression of pathological vascular remodeling in diabetes. Further basic and clinical research is required to confirm hypothesis.
