Household Pharmaceutical Waste Disposal as a Global Problem-A Review.

The negative effect of the pharmaceuticals presence (persistence?) in various components of the environment is a global problem today. These compounds are released into the environment as a result of, inter alia, their use and improper disposal. Therefore, it is important to reduce excessive drug consumption and to develop a system for the collection of unused/expired pharmaceuticals. The effectiveness of actions in this area is inextricably linked with the need to educate society on how to deal properly with unwanted medications. The aim of the study was to show that the inappropriate handling of unused/expired drugs by society is an important problem in waste management systems, and it impacts the state of the environment. Forty-eight scientific articles published between 2012 and 2021 were taken into account that discussed the systems in various countries for the collection of unused/expired pharmaceuticals. This literature review shows that the main method of disposing of unused/expired medications, according to respondents from different countries, is either by disposing of them in household waste or flushing them into the sewage system. This is also the case in countries with systems or programs for the return of redundant drugs, which indicates that these systems are not sufficiently effective. This may be influenced by many factors, including the lack or ineffective education of the society.

Poultry Farms as a Potential Source of Environmental Pollution by Pharmaceuticals.

Industrial poultry breeding is associated with the need to increase productivity while maintaining low meat prices. Little is known about its impact on the environment of soil pollution by pharmaceuticals. Breeders routinely use veterinary pharmaceuticals for therapeutic and preventive purposes. The aim of this work was to determine the influence of mass breeding of hens on the soil contamination with 26 pharmaceuticals and caffeine. During two seasons-winter and summer 2019-15 soil samples were collected. Liquid extraction was used to isolate analytes from samples. Extracts were analyzed using ultra-high performance liquid chromatography coupled with tandem mass spectrometry detection (UPLC-MS/MS). The results showed the seasonal changes in pharmaceutical presence in analyzed soil samples. Ten pharmaceuticals (metoclopramide, sulphanilamide, salicic acid, metoprolol, sulphamethazine, nimesulide, carbamazepine, trimethoprim, propranolol, and paracetamol) and caffeine were determined in soil samples collected in March, and five pharmaceuticals (metoclopramide, sulphanilamide, sulphamethazine, carbamazepine, sulfanilamid) in soil samples collected in July. The highest concentrations were observed for sulphanilamide, in a range from 746.57 ± 15.61 ng/g d.w to 3518.22 ± 146.05 ng/g d.w. The level of bacterial resistance to antibiotics did not differ between samples coming from intensive breeding farm surroundings and the reference area, based on antibiotic resistance of 85 random bacterial isolates.

The Influence of Ionic Liquids on the Effectiveness of Analytical Methods Used in the Monitoring of Human and Veterinary Pharmaceuticals in Biological and Environmental Samples-Trends and Perspectives.

Recent years have seen the increased utilization of ionic liquids (ILs) in the development and optimization of analytical methods. Their unique and eco-friendly properties and the ability to modify their structure allows them to be useful both at the sample preparation stage and at the separation stage of the analytes. The use of ILs for the analysis of pharmaceuticals seems particularly interesting because of their systematic delivery to the environment. Nowadays, they are commonly detected in many countries at very low concentration levels. However, due to their specific physiological activity, pharmaceuticals are responsible for bioaccumulation and toxic effects in aquatic and terrestrial ecosystems as well as possibly upsetting the body's equilibrium, leading to the dangerous phenomenon of drug resistance. This review will provide a comprehensive summary of the use of ILs in various sample preparation procedures and separation methods for the determination of pharmaceuticals in environmental and biological matrices based on liquid-based chromatography (LC, SFC, TLC), gas chromatography (GC) and electromigration techniques (e.g., capillary electrophoresis (CE)). Moreover, the advantages and disadvantages of ILs, which can appear during extraction and separation, will be presented and attention will be given to the criteria to be followed during the selection of ILs for specific applications.

Environmental Risk Assessment Resulting from Sediment Contamination with Perfluoroalkyl Substances.

Due to wide use of perfluoroalkyl substances (PFASs) (e.g., in metal-plating, in fire-fighting foam, lubricants) and their resistance to degradation, they occur widely in the environment. The aim of this study was to estimate the environmental risk resulting from the presence of PFASs in the Gulf of Gdansk. Therefore, 17 PFASs concentrations were determined using ultra performance liquid chromatography with tandem mass spectrometry detection (UPLC-MS/MS). Additionally, sediment ecotoxicity was investigated. The results of the chemical analysis were used to asses environmental risk of PFASs. In samples collected around discharge collectors from a wastewater treatment plant and the Vistula mouth, Σ17PFASs values were 0.00403 ÷ 40.6 and 0.509 ÷ 614 ng/g d.w., respectively. In samples collected around discharge collectors, PFHxA, PFPeA, PFHpA, and PFOA were dominating, while at the Vistula River mouth, PFHxS, PFDS, and PFBS were prevalent. For most sediments, no toxic effect was observed in the toxicity tests with Heterocypris inconguens and Aliivibrio ficsheri. There was no observed correlation between the PFASs level and their ecotoxicity. Generally, the results of environmental risk assessment indicate that the PFASs would not generate high impact on the aquatic life (five water samples have shown medium risk related to PFBS and PFDoA).

Micropollutants in treated wastewater.

Compounds such as pharmaceuticals, or personal care products are only partially removed in wastewater treatment processes. Large number of these compounds and their degradation products is out of any control. A small number of compounds are covered by legal regulations. Among the compounds non-regulated by law, the target compounds, as well as non-target compounds can be distinguished. In the scientific literature, number of reports on various target compounds' determination is increasingly growing. This paper provides an up-to-date review on micropollutants present in treated wastewater and their concentrations found in literature in the years 2015-2019. Because the obtained results of chemical analyses do not adequately reflect the risks to ecosystems and consequently humans, the results of chemical analyses have been supplemented by a review of ecotoxicological studies. In addition, legal issues linked to contamination of treated wastewater and research related to identification of non-target compounds in treated effluents have been discussed.

Pharmaceutical Household Waste Practices: Preliminary Findings from a Case Study in Poland.

Pharmaceutical consumption continues to grow constantly. Unused/expired pharmaceuticals are disposed of to the municipal sewage system or waste disposal. Consequently, many countries have implemented a system of collecting pharmaceutical waste, with pharmacies playing an important role. It is important to educate consumers on rational consumption and the appropriate disposal of unused/expired pharmaceuticals and to identify the level of public awareness. Two studies were conducted in Poland to estimate the problem of collection and disposal of expired/unused pharmaceuticals. The purpose of the Survey I was to identify the scale of pharmaceutical consumption and the way pharmaceuticals are disposed of by various social groups. The Survey II was aimed to identify patients' attitudes regarding expired/unused pharmaceuticals at home. Of the respondents who participated in in Survey I, almost 74% indicated that analgesics were among the over-the-counter drugs they purchased. Group of pharmaceuticals 65% of the respondents purchased were medicines for treating flu symptoms. Almost 68% of the respondents said they usually disposed of expired pharmaceuticals in their household waste or by flushing them down the toilet. In Survey II more than 35% reported that they disposed of pharmaceuticals in the same ways. Of all respondents, ~30% returned their expired pharmaceuticals to pharmacies. Most respondents (over 65%) who participated Survey I indicated that they were aware that pharmaceutical waste can be returned to pharmacies. It should be noted that local governments are currently not obliged by law to work with or compensate pharmacies in the collection and proper disposal of unused pharmaceuticals.

Gadolinium as a new emerging contaminant of aquatic environments.

Since the 1980s, gadolinium (Gd)-based contrast agents (GBCAs) have been routinely used in magnetic resonance imaging as stable chelates of the Gd3+ ion, without toxic effects. Generally, GBCAs are considered some of the safest contrast agents. However, it has been observed that they can accumulate in patient tissue, bone, and probably brain (causing nephrogenic systemic fibrosis in patients with kidney failure or insufficiency and disturbance of calcium homeostasis in the organism). The GBCAs are predominantly removed renally without metabolization. Subsequently, they do not undergo degradation processes in wastewater-treatment plants and are emitted into the aquatic ecosystem. Their occurrence was confirmed in surface waters (up to 1100 ng/L), sediments (up to 90.5 µg/g), and living organisms. Based on a literature review, there is a need to investigate the contamination of different ecosystems and to ascertain the environmental fate of Gd. Long-term ecotoxicological data, degradation, metabolism, bioaccumulation processes, and biochemical effects of the Gd complexes should be explored. These data can be used to assess detailed environmental risks because currently only hotspots with high levels of Gd can be marked as dangerous for aquatic environments according to environmental risk assessments. Environ Toxicol Chem 2018;37:1523-1534. © 2018 SETAC.

Elemental sulfur in sediments: analytical problems.

In the paper, a modified method for elemental sulfur (S8) determining using gas chromatography coupled with mass spectrometry (GC-MS) is proposed with estimation of selected validation parameters. The aim of this work was a review of problems associated with the determination of S8 and selection of the most optimal conditions for S8 analysis with GC-MS. The presented studies have shown that the temperature of the injector and the chromatographic column during S8 determination should not exceed 180 °C. At temperatures over 180 °C, the sulfur S8 is decomposed to the other sulfur species such as S2, S3, S4, S5, and S6. During decreasing injector and column temperature below 180 °C the chromatographic peak eluted as S8 is badly extended and asymmetric. To minimize the problems of S8 decomposition to other sulfur species during chromatographic process also other parameters of the GC-MS have been selected. In order to apply the proposed method for real sediments samples, determination of sulfur S8 in bottom sediments, collected in the Gulf of Gdansk (southern Baltic Sea), has been performed. The concentration of S8 fell in the range from below the limit of detection to 0.1432 ± 0.0095 mg/g d.w. The research has also shown that addition of approx. 200 mg of activated copper is effective for removing sulfur from bottom sediment extracts.

Polychlorinated biphenyls (PCBs) in bottom sediments: identification of sources.

Polychlorinated biphenyls (PCBs) can enter the environment from various sources. They are synthetic chemicals and as such are present in the environment mainly as mixtures containing various amounts of PCB congeners. It is therefore difficult to pinpoint the source of PCB emissions into the environment and the pathways along which they migrate there. The situation is different where locating the emission sources of polycyclic aromatic hydrocarbons (PAHs) is concerned. There is much information in the literature on the molecular markers that can be used to identify the sources of PAH emissions into the environment. Environmental samples like soil or bottom sediments are usually analysed for their contents of both groups of compounds. Therefore, with data on the origins of PAHs to hand, and seeking and comparing mutual correlations, one can attempt to define the probable sources of emission of PCBs. The purpose of this work was to identify the probable PCBs emission sources in bottom sediments using available data, that is polycyclic aromatic hydrocarbon diagnostic ratios. The numerical ratios of pairs of compounds such as fluoranthene/pyrene, phenanthrene/anthracene, fluoranthene/(fluoranthene+pyrene) and chrysene/benzo[a]anthracene are generally used as a tool for identifying and assessing pollution emission sources.

Novel approach to ecotoxicological risk assessment of sediments cores around the shipwreck by the use of self-organizing maps.

Marine and coastal pollution plays an increasingly important role due to recent severe accidents which drew attention to the consequences of oil spills causing widespread devastation of marine ecosystems. All these problems cannot be solved without conducting environmental studies in the area of possible oil spill and performing chemometric evaluation of the data obtained looking for similar patterns among pollutants and optimize environmental monitoring during eventual spills and possible remediation actions - what is the aim of the work presented. Following the chemical and ecotoxicological studies self-organising maps technique has been applied as a competitive learning algorithm based on unsupervised learning process. Summarizing it can be stated that biotests enable assessing the impact of complex chemical mixtures on the organisms inhabiting particular ecosystems. Short and simple application of biotests cannot easily explain the observable toxicity without more complex chemometric evaluation of datasets obtained describing dependence between xenobiotics and toxicological results.

Toxicity assessment of sediments associated with the wreck of s/s Stuttgart in the Gulf of Gdansk (Poland).

The paper presents the results of toxicity determinations carried out on sediment samples collected in the vicinity of the wreck of the German s/s Stuttgart (the southern part of the Gulf of Gdansk, off the Polish coast) in relation to the determination of polycyclic aromatic hydrocarbons (PAHs). The toxicity of surface and core sediment samples was assessed using two biotest organisms-the bioluminescent bacteria Vibrio fischeri and the ostracod Heterocypris incongruens. PAH levels in these samples were determined by GC-MS. The surface sediments collected at W2 (ca. 34 m north of the shipwreck) and W4 (ca. 415 m north-east of the wreck) as well as the core sediments collected at WR3 (ca. 400 m north-east of the wreck) were the most heavily polluted with substances toxic to the biotest organisms. The chronic and acute toxicities in the case of most of the surface sediment samples studied are correlated. This may suggest that not only hydrophobic chemicals (like PAHs from fuel residues) but also more polar chemicals (resulting from the conversion of aromatic hydrocarbons) are responsible for the toxicity levels found. There is a clear dependence between the levels of chronic toxicity and PAH concentrations in the core sediment samples. In addition, a simultaneous decrease in the PAH content and chronic toxicity was noted in all the core sediment samples at depths below 80 cm.

Impacts of pollution derived from ship wrecks on the marine environment on the basis of s/s "Stuttgart" (Polish coast, Europe).

In 1943 the German hospital ship s/s Stuttgart (Lazaretschiff "C") was sunk close to the port of Gdynia (Gulf of Gdansk - Polish coast). This and other actions (undertaken after the war to remove the wreck) led to pollution of the sea bottom with oil derivatives. During our studies (2009) 11 surface sediment and water samples were collected as well as sediment core samples at 4 locations in order to determine the concentration levels of priority pollutants belonging to polycyclic aromatic hydrocarbons (PAH) and polychlorinated biphenyls (PCB). The concentrations of 16 PAH and 7 PCB were analysed with GC-MS. ΣPAH varied between 11.54 ± 0.39 and 206.7 ± 6.5mg/kg dry weight in the surface sediments, and from 0.686 ± 0.026 to 1291 ± 53 mg/kg dry weight in the core samples. Contamination in the core samples collected may reach a depth of at least 230-240 cm (deepest sample studied). The PAH-group profiles in all surface sediment samples suggest a pyrolytic source of PAH, while the results obtained for core samples indicate a mixed pattern of pyrolytic and petrogenic inputs of PAH. Results obtained may suggest also that fuel residues being present at sea bottom is not crude oil derived but results from coal processing (synthetic fuel). The sum of PCB in surface sediments ranged from 0.761 ± 0.068 to 6.82 ± 0.28 µg/kg dry weight (except for sampling point W2, where ΣPCB was 108.8 ± 4.4 µg/kg dry weight). The strong correlation between PAH and PCB levels, and the fact that PCB are present only in the surface sediments, suggest that the compounds in these sediments got there as a result of emission from urban areas, entering the aquatic environment via atmospheric deposition. PCB levels in the sediment core samples were generally very low and in most cases did not exceed the method quantification limit.

Environmental implications of oil spills from shipping accidents.

Since ancient times, ships have sunk during storms, either as a result of collisions with other vessels or running onto rocks. However, the ever-increasing importance of crude oil in the twentieth century and the corresponding growth in the world's tanker fleet have drawn attention to the negative implications of sea transport. Disasters involving tankers like the Torrey Canyon or the Amoco Cadiz have shown how dramatic the consequences of such an accident may be. The effects of oil spills at sea depend on numerous factors, such as the physicochemical parameters of the oil, the characteristics of the environment affected, and the physical, chemical, and biological processes occurring there, such as evaporation, dissolution, dispersion, emulsification, photo-oxidation, biodegradation, and sedimentation. The combination of these processes reduces the concentrations of hydrocarbons in sediments and water and alters the chemical composition of spilled oils. In every case, oil spills pose a danger to fauna and flora and cause damage to sea and shores ecosystems. Many of the petroleum-related chemicals that are spilled are toxic, otherwise carcinogenic or can be bioaccumulated in the tissues of marine organisms. Such chemicals may then be biomagnified up the marine food chain from phytoplankton to fish, then to seals and other carnivorous sea mammals. Moreover, oil products can be accumulated and immobilized in bottom deposits for long periods of time. Oil spills are particularly dangerous when they occur in small inland seas that have intense sea traffic, e.g., the Baltic Sea.