Giving a Voice to Patients With Smell Disorders Associated With COVID-19: Cross-Sectional Longitudinal Analysis Using Natural Language Processing of Self-Reports.

BACKGROUND: Smell disorders are commonly reported with COVID-19 infection. The smell-related issues associated with COVID-19 may be prolonged, even after the respiratory symptoms are resolved. These smell dysfunctions can range from anosmia (complete loss of smell) or hyposmia (reduced sense of smell) to parosmia (smells perceived differently) or phantosmia (smells perceived without an odor source being present). Similar to the difficulty that people experience when talking about their smell experiences, patients find it difficult to express or label the symptoms they experience, thereby complicating diagnosis. The complexity of these symptoms can be an additional burden for patients and health care providers and thus needs further investigation. OBJECTIVE: This study aims to explore the smell disorder concerns of patients and to provide an overview for each specific smell disorder by using the longitudinal survey conducted in 2020 by the Global Consortium for Chemosensory Research, an international research group that has been created ad hoc for studying chemosensory dysfunctions. We aimed to extend the existing knowledge on smell disorders related to COVID-19 by analyzing a large data set of self-reported descriptive comments by using methods from natural language processing. METHODS: We included self-reported data on the description of changes in smell provided by 1560 participants at 2 timepoints (second survey completed between 23 and 291 days). Text data from participants who still had smell disorders at the second timepoint (long-haulers) were compared with the text data of those who did not (non-long-haulers). Specifically, 3 aims were pursued in this study. The first aim was to classify smell disorders based on the participants' self-reports. The second aim was to classify the sentiment of each self-report by using a machine learning approach, and the third aim was to find particular food and nonfood keywords that were more salient among long-haulers than those among non-long-haulers. RESULTS: We found that parosmia (odds ratio [OR] 1.78, 95% CI 1.35-2.37; P<.001) as well as hyposmia (OR 1.74, 95% CI 1.34-2.26; P<.001) were more frequently reported in long-haulers than in non-long-haulers. Furthermore, a significant relationship was found between long-hauler status and sentiment of self-report (P<.001). Finally, we found specific keywords that were more typical for long-haulers than those for non-long-haulers, for example, fire, gas, wine, and vinegar. CONCLUSIONS: Our work shows consistent findings with those of previous studies, which indicate that self-reports, which can easily be extracted online, may offer valuable information to health care and understanding of smell disorders. At the same time, our study on self-reports provides new insights for future studies investigating smell disorders.

Relationship between pineal gland, sleep and melatonin in fibromyalgia women: a magnetic resonance imaging study.

A total of 80% of fibromyalgia (FM) population have reported poor sleep. In this regard, the pineal gland, involved in circadian rhythm processes as a key neuroendocrine organ which mainly synthesises and secretes melatonin, has never been studied before in this population. Therefore, this study aimed to evaluate the parenchyma pineal volume and its relation to sleep hours, sleep quality index and melatonin level at night. A total of 50 participants, 30 women with FM and 20 healthy control women underwent cranial magnetic resonance imaging. The total pineal volume, cyst pineal volume and parenchyma pineal volume were manually calculated in cubic millimetres. Also, the total pineal volume was estimated using Hasehawa method. Parenchyma pineal volume was significantly correlated with sleep hours (p-value = 0.041) and nocturnal melatonin level (p-value = 0.027). Moreover, there was also a non-significant correlation between parenchyma pineal volume and sleep quality index (p-value = 0.055). Furthermore, a mean parenchyma pineal volume of 102.00 (41.46) mm³ was observed, with a prevalence of 29.60% cyst in FM group. This is the first study that has reported pineal gland volumes, cyst prevalence and correlative relationships between parenchyma pineal volume and sleep hours and melatonin levels in women with FM.

Relationships of Adolescent and Young Couples with Violent Behaviors: Conflict Resolution Strategies.

Violence in adolescent and young couples is a major issue given its high prevalence and the serious consequences that it brings. For this reason, this research has stated two main objectives. In the first place, to ascertain the level of agreement between both members of the couple both with regard to occurrence and frequency of violence. Second, to ascertain the level of agreement on the frequency of use of conflict resolution strategies in problematic situations in 141 heterosexual couples. The age of the sample was between 17 and 30. The tools used were the DVQ-R questionnaire and the Spanish adaptation by Bonache, Ramírez-Santana, and González-Mendez (2016) of the Inventory of Conflict Resolution Styles (CSRI)The results indicate that of the 141 couples in the sample, 112 were identified as violent, thus indicating a high prevalence of violence within their partner relationships. Regarding the levels of agreement and accordance, statistically significant discrepancies are reflected in the perception of violence between men and women, analyzing both roles (aggression and victimization). Finally, also noteworthy is use of the strategy of negative involvement in conflicts, with significant differences in relation to sex; it is the girls who make the most use of this strategy, and the high level of agreement on the frequency of problem-solving is reflected on that strategy.

MoCA vs. MMSE of Fibromyalgia Patients: The Possible Role of Dual-Task Tests in Detecting Cognitive Impairment.

Fibromyalgia is a syndrome that is characterized by widespread pain; fatigue; stiffness; reduced physical fitness; sleep disturbances; psychological symptoms, such as anxiety and depression; and deficits in cognitive functions, such as attention, executive function, and verbal memory deficits. It is important to analyze the potentially different performance on the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) test in patients with fibromyalgia as well as examine the relationship of that performance with physical and cognitive performance. A total of 36 women with fibromyalgia participated in the study. Participants completed the MoCA test, the MMSE, and the TUG physical fitness test under dual-task conditions. The results obtained on cognitive tests were 28.19 (1.74) on the MMSE and 25.17 (2.79) on the MoCA. The participants' performance on cognitive tests was significantly related to the results of the TUG dual-task test. In this way, cognitive performance on a dual-task test can be used to support the diagnosis of cognitive impairment in patients with fibromyalgia. The MoCA test may be a more sensitive cognitive screening tool than the MMSE for patients with fibromyalgia.

Effects of a home-based exercise program on mental health for caregivers of relatives with dementia: a randomized controlled trial.

OBJECTIVE: This study was aimed to evaluate the effectiveness of a home-based physical exercise program on participants' mental health: psychological symptoms, depression, and burden of female informal caregivers. DESIGN AND PARTICIPANTS: In a randomized controlled trial, a sample of 48 female informal primary caregivers completed the entire study, 25 were randomly allocated to the intervention group (IG), and 23 participants to the control group (CG). INTERVENTION: Participants in the IG performed two 60-minute-long physical exercise sessions per week (36 weeks) that were supervised by a personal trainer at caregivers' home during 9 months. The CG continued their habitual leisure-time activities. MEASUREMENTS: Subjective burden was assessed by the Zarit Burden Interview. The risk of depression was measured by the Geriatric Depression Scale Short Form 15-item version, and psychological symptoms were evaluated by the Symptom Check List-90-Revised (SCL-90-R). All participants were evaluated at baseline and at the end of the intervention. RESULTS: A promising positive impact of the intervention on caregivers' subjective burden and risk of depression was found in the IG. In addition, no significant between-group differences were found in any of nine subscales scores of the SCL-90-R. Finally, care recipients' level of functional independence and area of residence were found to be predictors of the promising positive impact on caregivers' subjective burden and risk of depression. CONCLUSIONS: The present home-based physical exercise intervention that was individually implemented has shown promising results to reduce subjective burden and risk of depression in female caregivers of relatives with dementia. However, future research efforts should elucidate both the particular dose of physical exercise and the particular duration of the intervention that are required to obtain the expected significant positive impact. Finally, future inclusion of psychological approaches, besides physical exercise, might help reduce female caregivers' psychological symptoms.

New insights into the ontogeny of human vegetable consumption: From developmental brain and cognitive changes to behavior.

Relatively little is known about how mental development during childhood parallels brain maturation, and how these processes may have an impact on changes in eating behavior: in particular in vegetable consumption. This review aims to bridge this research gap by integrating both recent findings from the study on brain maturation with recent results from research on cognitive development. Developmental human neuroscientific research in the field of the sensory systems and on the relationship between children's cognitive development and vegetable consumption serve as benchmarks. We have identified brain maturation and mental growth patterns that may affect child vegetable consumption and conclude that both of these developmental patterns partially match with the Piagetian theory of development. Additionally, we conclude that a series of potential modulating factors, such as learning-related experiences, may lead to fluctuations in the course of those particular developmental patterns, and thus vegetable consumption patterns. Therefore, we propose a theoretical predictive model of child vegetable consumption in which the nature of the relationship between its correlational and/or causal components should be studied in the future by adopting an integral research perspective of the three targeted study levels: brain, cognition and behavior.

More Than Smell-COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis.

Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change ±100) revealed a mean reduction of smell (-79.7 ± 28.7, mean ± standard deviation), taste (-69.0 ± 32.6), and chemesthetic (-37.3 ± 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.

Effects of Exergames on Brain Dynamics in Women with Fibromyalgia: A Randomized Controlled Trial.

BACKGROUND: Exergames are non-immersive versions of virtual reality that involve physical exercise and have shown several benefits on physical fitness and quality of life in women with fibromyalgia. However, the effects on brain dynamics are still unknown. AIM: the aim was to evaluate the effects of a 24-week exergame intervention on resting brain dynamics in women with fibromyalgia in a single-blinded, randomized controlled trial. METHODS: Fifty-six women with fibromyalgia were assessed for eligibility; 55 fulfilled the inclusion criteria. The exercise group completed a 24-week exergame-based intervention that focused on mobility, postural control, upper and lower limb coordination, aerobic fitness, and strength. This group received two 60-min sessions per week. We measured electroencephalographic (EEG) signals from 19 channels. Participants were also divided into two subgroups according to the duration of their symptoms. The intervention was more effective in the group with a shorter duration of symptoms, showing between-group differences in F8, T5 and T4. CONCLUSION: Exergames may lead to changes in brain dynamics that could be related to increased cerebral blood flow.

A minireview of effects of maternal diet during pregnancy on postnatal vegetable consumption: Implications for future research (a new hypothesis) and recommendations.

The flavor of the maternal diet is transferred to the amniotic fluid and in this way the amniotic fluid becomes a transmitter of flavor-related information, developing babies can perceive in uterus. We aimed to review the available evidence regarding the impact of prenatal exposure to flavor on postnatal vegetable-related eating behavior. Studies of our focus have been the ones that have ad hoc examined the association of prenatal experience with vegetable-related flavors with vegetable consumption in children. We have identified that some studies have found this association, against others. Particularly, the first group of studies found an increased vegetable intake at weaning and late childhood associated with prenatal flavor exposure. The second set, instead, did not find this association of variables at early childhood. We propose here that the vegetable type used in these last studies might explain this disparity of results, and suggest the following hypothesis to be tested in the future: prenatal exposure to nonbitter vegetables leads to an increased vegetable consumption at early childhood in comparison to prenatal exposure to bitter vegetables, postnatal exposure to vegetables and no exposure. The experimental design of this hypothesis as well as subsequent recommendations for future research and maternal diet are also here suggested.

Promoting our understanding of neural plasticity by exploring developmental plasticity in early and adult life.

Developmental plasticity (DP) is widely considered to be a property of early life stages, but evidence suggests it can be reactivated in mature brains. For example, recent developments on animal models suggest that experience in enriched environments (EE) can induce DP and enable adult recovery from amblyopia; even when the typical critical period for that recovery has closed. An interesting body of evidence suggests that extrapolation of the rejuvenatory power of that paradigm in mature human brains is feasible. These studies show that exposure to EE throughout life is associated with a delay, or even prevention, of age-related cognitive deficits. Consequently, it can be concluded that DP might underlie the neuroprotective effects against a neurocognitive breakdown that have been observed, and that EE exposure later in life might induce DP in a similar way to early EE exposure. Thus, the DP might exert its influence beyond the typical developing age ranges: childhood and adolescence. Although further research is still required, the observation of EE related neuroprotective effects are a breakthrough in the study of DP in humans and new advances in our understanding of neural plasticity have thus been reached.

Studying the effects of smell and taste experience in the pediatric population using functional near infrared spectroscopy: a hypothesis.

There are different postnatal sensitive periods throughout the development course of sensory functions. During sensitive periods, there is a biological display of an extreme neural sensitivity to the storage of experience-driven sensory information that is not present outside these developmental stages. This neural property is reflected in subjects' reported preferences for sensory stimuli, such as odors and tastes. The human brain mapping approach (HBA) has demonstrated that disease-free human postnatal and later development of any sensory function parallels morphological and functional development of the CNS and that this development correlates with signal changes that have been acquired by means of neuroimaging techniques. Whether experience with tastes and/or odors has a stronger effect on the perception of gustatory and/or olfactory stimuli the earlier subjects are exposed to certain odors and tastes is still unknown. It is also unknown, whether as well as how this effect is reflected in brain activation patterns and whether we are currently able to identify sensitive periods of gustatory and olfactory development from the imaging signals. To answer these research questions, repeated exposure to tastes and/or odors should be applied in children of different age ranges in order to induce different age-related degrees of olfactory/gustatory preferences as well as different aged-related patterns of oxyhemoglobin (OH) and deoxyhemoglobin (DOH) changes that should be measured by means of the functional near-infrared spectroscopy (fNIRS) technique.