ABSTRACT
The review presents a modern view on the functional--morphological peculiarities of 12 segments of the nephron canaliculi possessing some functional, biochemical and histologic distinctions that should be taken into account to study physiology, biochemistry, morphology and pathophysiology of the kidney.
Subject(s)
Nephrons/anatomy & histology , Nephrons/physiology , Animals , Biochemical Phenomena , Biochemistry , Humans , Kidney Cortex/anatomy & histology , Kidney Cortex/physiology , Kidney Cortex/physiopathology , Kidney Medulla/anatomy & histology , Kidney Medulla/physiology , Kidney Medulla/physiopathology , Kidney Tubules, Collecting/anatomy & histology , Kidney Tubules, Collecting/physiology , Kidney Tubules, Collecting/physiopathology , Kidney Tubules, Distal/anatomy & histology , Kidney Tubules, Distal/physiology , Kidney Tubules, Distal/physiopathology , Kidney Tubules, Proximal/anatomy & histology , Kidney Tubules, Proximal/physiology , Kidney Tubules, Proximal/physiopathology , Loop of Henle/anatomy & histology , Loop of Henle/physiology , Loop of Henle/physiopathology , Models, Biological , Nephrons/physiopathology , PhysiologyABSTRACT
The experiments were carried out on 36 male rats with an acute renal insufficiency--sublimate-induced nephropathy. An increased amount of both tromboxan A2, and prostaglandine F2a has been shown to play a pathogenic role in the disorders of the main energy-dependent process in kidney--reabsorbtion of sodium ions. The negative correlative relation between the concentration of sodium ions in plasma and an increased amount of prostaglandine E2 in a kidney papilla can be explained by the hyperfunction of the interstitial cells of a kidney papilla and with a natriuretic effect of prostaglandine E2 at the level of collective tubules.
Subject(s)
Acute Kidney Injury/physiopathology , Kidney/metabolism , Prostaglandins/physiology , Sodium/metabolism , Absorption , Animals , Dinoprost/physiology , Dinoprostone/physiology , Kidney/physiopathology , Kidney Medulla/metabolism , Kidney Tubules, Collecting/metabolism , Male , Rats , Thromboxane A2/physiologyABSTRACT
The protective effect of Wobe-Mugos appliance on the kidney function and biochemical state in polyuric stage of sublimate nephropathia at the moment of tubulointerstitial component formation was revealed in experiments on 40 white male rats. It appeared in the increase of hydrogenous ion excretion, titred acids, renal tissue fibrinolytic and proteolytic activity. The succinatdehydrogenase activation in renal cortex matter pointed out on the improvement of energy balance.
