1.
Angew Chem Int Ed Engl
; 56(36): 10900-10904, 2017 08 28.
Article
in English
| MEDLINE
| ID: mdl-28686815
ABSTRACT
Re2 O7 catalysis effects efficient and stereoselective dehydrative cyclization reactions from monoallylic diols, with stereocontrol arising from thermodynamic equilibration. This method was applied to a rapid synthesis of the spliceosome inhibitor herboxidiene. The route was also utilized for the synthesis of an analogue that highlights the importance of a single methyl group in biasing the conformation in the acyclic region of the molecule.