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1.
Bone Joint J ; 98-B(8): 1050-5, 2016 Aug.
Article in English | MEDLINE | ID: mdl-27482016

ABSTRACT

AIMS: The Advance Medial-Pivot total knee arthroplasty (TKA) was designed to reflect contemporary data regarding the kinematics of the knee. We wished to examine the long-term results obtained with this prosthesis by extending a previous evaluation. PATIENTS AND METHODS: We retrospectively evaluated prospectively collected data from 225 consecutive patients (41 men and 184 women; mean age at surgery 71 years, 52 to 84) who underwent 284 TKAs with a mean follow-up of 13.4 years (11 to 15). Implant failure, complication rate, clinical (both subjective and objective) and radiological outcome were assessed. Pre- and post-operative clinical and radiographic data were available at regular intervals for all patients. A total of ten patients (4.4%; ten TKAs) were lost to follow-up. RESULTS: Survival analysis at 15 years showed a cumulative success rate of 97.3% (95% confidence interval (CI) 96.7 to 97.9) for revision for any reason, of 96.4% (95% CI 95.2 to 97.6) for all operations, and 98.8% (95% CI 98.2 to 99.4) for aseptic loosening as an end point. Three TKAs (1.06%) were revised due to aseptic loosening, two (0.7%) due to infection, one (0.35%) due to instability and one (0.35%) due to a traumatic dislocation. All patients showed a statistically significant improvement on the Knee Society Score (p = 0.001), Western Ontario and McMaster University Osteoarthritis Index (p = 0.001), Short Form-12 (p = 0.01), and Oxford Knee Score (p = 0.01). A total of 207 patients (92%) were able to perform age appropriate activities with a mean flexion of the knee of 117° (85° to 135°) at final follow-up. CONCLUSION: This study demonstrates satisfactory functional and radiographic long-term results for this implant. Cite this article: Bone Joint J 2016;98-B:1050-5.


Subject(s)
Arthroplasty, Replacement, Knee/instrumentation , Knee Prosthesis , Osteoarthritis, Hip/surgery , Aged , Aged, 80 and over , Arthroplasty, Replacement, Knee/adverse effects , Female , Follow-Up Studies , Hip Joint/diagnostic imaging , Humans , Male , Middle Aged , Osteoarthritis, Hip/diagnostic imaging , Pain, Postoperative/prevention & control , Patient Satisfaction , Prospective Studies , Prosthesis Design , Prosthesis Failure/adverse effects , Prosthesis-Related Infections/etiology , Retrospective Studies , Treatment Outcome
2.
Bone Joint J ; 95-B(7): 887-92, 2013 Jul.
Article in English | MEDLINE | ID: mdl-23814238

ABSTRACT

We report the results at a mean of 24.3 years (20 to 32) of 61 previously reported consecutive total hip replacements carried out on 44 patients with severe congenital hip disease, performed with reconstruction of the acetabulum with an impaction grafting technique known as cotyloplasty. The mean age of the patients at operation was 46.7 years (23 to 68) and all were women. The patients were followed post-operatively for a mean of 24.3 years (20 to 32), using the Merle d'Aubigné and Postel scoring system as modified by Charnley, and with serial radiographs. At the time of the latest follow-up, 28 acetabular components had been revised because of aseptic loosening at a mean of 15.9 years (6 to 26), and one at 40 days after surgery because of repeated dislocations. The overall survival rate for aseptic failure of the acetabular component at ten years was 93.1% (95% confidence interval (CI) 86.5 to 96.7) when 53 hips were at risk, and at 23 years was 56.1% (95% CI 49.4 to 62.8), when 22 hips remained at risk. These long-term results are considered satisfactory for the reconstruction of an acetabulum presenting with inadequate bone stock and circumferential segmental defects.


Subject(s)
Acetabulum/injuries , Arthroplasty, Replacement, Hip/methods , Bone Transplantation/methods , Hip Dislocation, Congenital/surgery , Hip Joint/surgery , Hip Prosthesis/adverse effects , Postoperative Complications/epidemiology , Acetabulum/surgery , Adult , Aged , Aged, 80 and over , Female , Follow-Up Studies , Humans , Middle Aged , Postoperative Complications/etiology , Prosthesis Failure , Survival Rate , Treatment Outcome , Young Adult
3.
J Hand Surg Eur Vol ; 37(4): 354-8, 2012 May.
Article in English | MEDLINE | ID: mdl-22117010

ABSTRACT

The purpose of this study was to determine whether a radial shaft fracture would decrease the protection provided to the posterior interosseous nerve by the pronation maneuver during posterolateral exploration. The position of the nerve in 14 cadaveric elbows, before and after a radial osteotomy, was determined using CT scans in full supination and full pronation after injection of the nerve with radio-opaque dye. The angle formed by the olecranon, radial head and posterior interosseous nerve, and the distance between the nerve and the most lateral aspect of the radial head were measured.Pronation increased the distance between the lateral radial head and the nerve by a mean of 6.5 mm (range 3.6-10.7). After radial osteotomy, the mean increase was 4.2 mm (range 1.0-8.3), difference 2.3 mm (p = 0.044, 95% CI 0.10 to 3.33). The posterolateral approach requires additional care in the presence of a radial shaft fracture, but pronation is still beneficial.


Subject(s)
Forearm/innervation , Osteotomy , Peripheral Nerves/physiopathology , Pronation , Radius/surgery , Humans , In Vitro Techniques , Peripheral Nerves/diagnostic imaging , Radius/diagnostic imaging , Tomography, X-Ray Computed
4.
J Hand Surg Am ; 34(4): 630-6, 2009 Apr.
Article in English | MEDLINE | ID: mdl-19345865

ABSTRACT

PURPOSE: To evaluate the outcome of hand fractures managed with mini-external fixators (MEFs) in order to assess their usefulness in different fracture types and to make recommendations regarding potential applications. METHODS: Fifty-one patients with 59 metacarpal and phalangeal fractures were treated with MEFs. Fixators were used to reduce the fracture or to achieve volar plate arthroplasty when anatomical joint reconstruction was impossible. The mean period from injury to MEF application was 4.5 days. RESULTS: The procedure was performed using regional anesthesia and fluoroscopic control, and it lasted 20 to 45 minutes. MEFs were removed in a mean period of 6 weeks, and follow-up was 18 to 55 months. Forty-nine patients with 57 fractures remained in the follow-up group. In all cases the skeleton was successfully reconstructed, whereas the clinical outcome varied according to the type of the original injury: intra-articular fractures had worse outcome than extra-articular (p=.035 for grip strength and p=.0005 for total active motion), and open fractures had worse outcome than closed (p=.06 for grip strength and p=.001 for total active motion). In all cases, patients' satisfaction was high; the Disabilities of the Arm, Shoulder, and Hand score was <7.9 and the visual analog scale score was <0.5. CONCLUSIONS: The findings of this series demonstrate the efficacy of versatile MEFs to establish union and correct alignment of hand skeleton with minimal tissue trauma while retaining a good clinical outcome even in the most complex injuries. MEFs can be considered for all hand fractures requiring surgical treatment, and especially for the intra-articular and comminuted fractures. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.


Subject(s)
External Fixators , Finger Injuries/surgery , Finger Joint/surgery , Finger Phalanges/injuries , Finger Phalanges/surgery , Hand Injuries/surgery , Metacarpal Bones/injuries , Metacarpophalangeal Joint/injuries , Miniaturization/instrumentation , Equipment Design , Finger Injuries/diagnostic imaging , Finger Joint/diagnostic imaging , Fracture Healing/physiology , Fractures, Closed/diagnostic imaging , Fractures, Closed/surgery , Fractures, Open/diagnostic imaging , Fractures, Open/surgery , Hand Injuries/diagnostic imaging , Humans , Metacarpal Bones/surgery , Metacarpophalangeal Joint/diagnostic imaging , Metacarpophalangeal Joint/surgery , Postoperative Complications/diagnostic imaging , Radiography , Treatment Outcome
5.
J Bone Joint Surg Br ; 90(5): 584-91, 2008 May.
Article in English | MEDLINE | ID: mdl-18450623

ABSTRACT

We report the clinical and radiological results of a two- to three-year prospective randomised study which was designed to compare a minimally-invasive technique with a standard technique in total knee replacement and was undertaken between January 2004 and May 2007. The mini-midvastus approach was used on 50 patients (group A) and a standard approach on 50 patients (group B). The mean follow-up in both groups was 23 months (24 to 35). The functional outcome was better in group A up to nine months after operation, as shown by statistically significant differences in the mean function score, mean total score and the mean Oxford knee score (all, p = 0.05). Patients in group A had statistically significant greater early flexion (p = 0.04) and reached their greatest mean knee flexion of 126.5 degrees (95 degrees to 135 degrees ) 21 days after operation. However, at final follow-up there was no significant difference in the mean maximum flexion between the groups (p = 0.08). Technical errors were identified in six patients from group A (12%) on radiological evaluation. Based on these results, the authors currently use minimally-invasive techniques in total knee replacement in selected cases only.


Subject(s)
Arthroplasty, Replacement, Knee/methods , Knee Joint/surgery , Osteoarthritis, Knee/surgery , Aged , Aged, 80 and over , Arthroplasty, Replacement, Knee/standards , Female , Humans , Knee Joint/diagnostic imaging , Knee Prosthesis , Male , Middle Aged , Osteoarthritis, Knee/diagnostic imaging , Prospective Studies , Radiography , Range of Motion, Articular , Statistics as Topic , Treatment Outcome
6.
J Bone Joint Surg Br ; 86(3): 350-8, 2004 Apr.
Article in English | MEDLINE | ID: mdl-15125121

ABSTRACT

We investigated the effect of calcitonin in the prevention of acute bone loss after a pertrochanteric fracture and its ability to reduce the incidence of further fractures in the same patient. Fifty women aged between 70 and 80 years who had a pertrochanteric fracture of the hip were randomly allocated to group A (200 IU of nasal salmon calcitonin daily for three months) or group B (placebo). Patients in group A showed a significantly higher level of total alkaline phosphatase and osteocalcin on the 15th day after injury and a significantly higher level of bone alkaline phosphatase on the 90th day after surgery. These patients also had significantly lower levels of urinary C-telopeptide (CrossLaps) on the 15th, 45th and 90th days after injury and lower levels of urinary hydroxyproline on the 15th and 45th days after injury. Patients in group A had significantly higher bone mineral density at all recorded sites except the greater trochanter at three months and one year after operation. After a four-year period of clinical observation, five patients (24%) in group B sustained a new fracture, in four of whom (20%) it was of the contralateral hip. Our findings show that calcitonin reduces acute bone loss in patients with pertrochanteric fractures and may prevent the occurrence of new fractures of the contralateral hip in the elderly.


Subject(s)
Calcitonin/administration & dosage , Hip Fractures/drug therapy , Osteolysis/drug therapy , Acute Disease , Administration, Intranasal , Aged , Aged, 80 and over , Alkaline Phosphatase/analysis , Biomarkers/analysis , Bone Density/physiology , Collagen/urine , Collagen Type I , Female , Hip Fractures/metabolism , Humans , Hydroxyproline/urine , Osteocalcin/blood , Osteolysis/metabolism , Peptides/urine , Prospective Studies , Recurrence
7.
J Hand Surg Am ; 26(6): 1146-50, 2001 Nov.
Article in English | MEDLINE | ID: mdl-11721267

ABSTRACT

The dominant elbow joint of 24 healthy volunteers was immobilized with a functional brace in increments of 20 degrees (6 positions ranging from 30 degrees to 130 degrees ). Average scores were obtained for personal care hygiene tasks (PCH), activity of daily living (ADL), and total functional scores (PCH + ADL) for each elbow flexion position. Functional scores increased with increasing elbow flexion, peaking at 110 degrees and then tapering down. Repeated-measures analysis of variance showed statistical significance, with functional scores improving with increasing elbow flexion for PCH, ADL, and PCH + ADL scores. Further pairwise comparisons for elbow position between 90 degrees and 110 degrees flexion groups demonstrated significant higher mean functional scores for ADL and combined PCH + ADL for the 110 degrees group. The results of this study support a clear advantage in subjects' upper-extremity functional abilities with the elbow immobilized at 110 degrees of flexion when dealing with normal upper-extremity joints. This angle of flexion should be considered in patients undergoing trial immobilization before an elbow arthrodesis.


Subject(s)
Activities of Daily Living , Arthrodesis/adverse effects , Braces , Elbow Joint/physiopathology , Adult , Female , Humans , Male , Range of Motion, Articular
8.
Foot Ankle Int ; 22(2): 144-9, 2001 Feb.
Article in English | MEDLINE | ID: mdl-11249225

ABSTRACT

Fractures of the medial and lateral malleoli are frequently associated with fractures of the posterior malleolus, comprising trimalleolar fractures. The posterior fragment may be posteromedial or posterolateral and its size determines the necessity for surgical or non-surgical treatment. The authors describe a case of trimalleolar fracture with double involvement of the posterior malleolus, both a posteromedial and posterolateral fragment. A modified transmalleolar operative approach for internal fixation is recommended when dealing with such complex trimalleolar fractures of the ankle.


Subject(s)
Ankle Injuries/surgery , Ankle Joint/surgery , Fracture Fixation, Internal/methods , Fractures, Bone/surgery , Fractures, Comminuted/surgery , Ankle Injuries/classification , Ankle Injuries/complications , Emergencies , Female , Fractures, Bone/classification , Fractures, Bone/complications , Fractures, Comminuted/complications , Humans , Internal Fixators , Middle Aged
9.
Eur Spine J ; 9(3): 256-60, 2000 Jun.
Article in English | MEDLINE | ID: mdl-10905446

ABSTRACT

Hemangioma of the bone is a benign tumor usually involving the spine and the bones of the skull and pelvis. It may be either a single lesion or part of a generalized multifocal disease. Multiple lesions involving non-adjacent vertebrae are rare. Two cases of multiple vertebral hemangiomas at non-adjacent levels with different pain patterns are presented at various stages of follow-up in order to emphasize the fact that multiple vertebral hemangiomas may present with different clinical characteristics over a long period of time. The change in the location and pattern of the initially presented pain in both patients suggested the possibility of multiple level involvement. Investigation revealed multiple hemangiomas involving three non-adjacent vertebrae in the first patient and four in the second. We stress the fact that the existence of multiple non-adjacent lesions may remain undiagnosed for a considerable period of time and may be responsible for even longer-term recurrent episodes of pain. Multifocal location of back pain in patients with a known vertebral hemangioma may be considered a relative indication for the presence of multiple non-adjacent level lesions.


Subject(s)
Hemangioma/diagnosis , Low Back Pain/diagnosis , Lumbar Vertebrae/pathology , Spinal Neoplasms/diagnosis , Thoracic Vertebrae/pathology , Aged , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Female , Humans , Low Back Pain/drug therapy , Lumbar Vertebrae/blood supply , Lumbar Vertebrae/diagnostic imaging , Male , Middle Aged , Thoracic Vertebrae/blood supply , Thoracic Vertebrae/diagnostic imaging , Tomography, X-Ray Computed
11.
Spine (Phila Pa 1976) ; 24(22): 2318-24, 1999 Nov 15.
Article in English | MEDLINE | ID: mdl-10586455

ABSTRACT

STUDY DESIGN: A 10-year follow-up evaluation of the effectiveness of school screening for scoliosis performed in a closed island population. OBJECTIVES: To evaluate the diagnostic accuracy of methods used for screening scoliosis and to re-examine the long-term effectiveness of the school scoliosis screening program. SUMMARY OF BACKGROUND DATA: The diagnostic accuracy of the forward-bending test and the long-term efficacy of the screening programs have not been clearly established. METHODS: In 1987, 2700 pupils aged 8 to 16 years from the island of Samos were screened for scoliosis. The Adams forward-bending test, Moire topography, the scoliometer, and the humpometer were used. Radiologic evaluation of the spine was available for each pupil and the number of false-negative and false-positive results of the screening methods was calculated. Subsequently, sensitivity, specificity, and positive and negative predictive values were estimated for each screening technique. Pupils found positive for spinal deformity were then followed up regularly at yearly intervals. In 1997, all positive subjects attended a 10-year clinical and radiologic follow-up, and the remaining subjects were re-evaluated by a postal questionnaire and were clinically examined if necessary. RESULTS: Spinal deformity was found in 153 (5.66%) pupils. Scoliosis (defined as a spinal curvature > or = 10 degrees) was found in 32 pupils, for a prevalence of 1.18%. For scoliosis, the Adams forward-bending test showed a number of false-negative results (in five cases), for a sensitivity of 84.37% and specificity of 93.44%. The sensitivities of Moire topography, the humpometer, and the scoliometer were 100%, 93.75%, and 90.62%, respectively, and specificity was 85.38%, 78.11%, and 79.76% respectively. The negative predictive value of the forward-bending test was inferior to those of the other methods. During this scoliosis screening program, if cutoff limits for referral had been used, such as the asymmetry of two Moire fringes, a humpogram deformity of (D + H) = 10 mm, and 8 degrees of scoliometer angle, it would have been possible to reduce radiologic examination by 89.4%. Three (0.11%) pupils aged between 12 and 14 years with scoliotic deformities greater than 20 degrees underwent satisfactory nonoperative treatment with Boston braces. One pupil with a 40 degrees thoracic curvature, underwent satisfactory surgical treatment because of progression 1 year later. Of the 121 spinal deformities with an initial Cobb angle less than 10 degrees, 44 (35.8%), and of the 29 scoliotic deformities with an initial Cobb angle between 10 degrees and 20 degrees, 14 (48.3%) progressed (a Cobb angle difference of at least 5 degrees in more than one examination). Observation and physiotherapy were the only treatments applied to all except one of the pupils in these groups. CONCLUSIONS: The Adams forward-bending test cannot be considered a safe diagnostic criterion for the early detection of scoliosis (especially when it is used as the only screening tool) because it results in an unacceptable number of false-negative findings. For the early detection of scoliosis, a combination of back-shape analysis methods can be safely used with the introduction of cutoff limits for referral being a useful procedure. The incidence of significant scoliosis is low, and its natural history seems to be independent of early detection. The wide-spread use of school scoliosis screening with the use of the forward-bending test must be questioned.


Subject(s)
Mass Screening/methods , Physical Examination , School Health Services , Scoliosis/diagnosis , Adolescent , Child , Evaluation Studies as Topic , False Negative Reactions , Female , Follow-Up Studies , Greece/epidemiology , Humans , Male , Scoliosis/epidemiology , Time Factors
12.
Eur Spine J ; 8(4): 279-83, 1999.
Article in English | MEDLINE | ID: mdl-10483829

ABSTRACT

The authors present their experience in the operative treatment of unstable lesions at the cervicothoracic junction. Ten patients, six men and four women, underwent operative procedures at the cervicothoracic junction (C7-T1) between 1990 and 1997. Six patients had sustained fracture-dislocations, three patients had metastases and one patient had a primary malignant lesion. All the patients had significant cervical pain and neurologic deficit. The spinal cord and nerves were decompressed in all cases. Posterior stabilization was accomplished using various types of implants including hooks, wires and rods. Anteriorly, the spine was stabilized with plates and screws. Partial or complete vertebrectomy was performed in five cases and a titanium cylinder or an iliac autograft replaced the vertebral body. Five patients were submitted to a posterior operation only, and the other five to bilateral procedures. In four of these a one-stage operation was performed and in the last case a two-stage procedure. The anatomic and biomechanical characteristics of the cervicothoracic junction require a precise pre-operative analysis of the local anatomy and the selection of the proper implants for anterior and posterior stabilization.


Subject(s)
Cervical Vertebrae/injuries , Joint Dislocations/surgery , Joint Instability/surgery , Spinal Fractures/surgery , Thoracic Vertebrae/injuries , Adult , Aged , Cervical Vertebrae/diagnostic imaging , Cervical Vertebrae/surgery , Female , Humans , Joint Instability/diagnostic imaging , Joint Instability/etiology , Male , Middle Aged , Orthopedic Fixation Devices , Palliative Care , Postoperative Complications , Radiography , Retrospective Studies , Spinal Neoplasms/complications , Spinal Neoplasms/secondary , Spinal Neoplasms/surgery , Thoracic Vertebrae/diagnostic imaging , Thoracic Vertebrae/surgery
13.
Clin J Pain ; 15(4): 284-9, 1999 Dec.
Article in English | MEDLINE | ID: mdl-10617256

ABSTRACT

OBJECTIVE: To evaluate the analgesic efficacy of calcitonin suppositories (200 IU) in comparison with bed rest and paracetamol tablets, as a rescue analgesic. DESIGN: A prospective, double-blind, randomized, placebo-controlled, clinical trial. PATIENTS: Forty patients (8 men and 32 postmenopausal women), who had recently (within the last 5 days) suffered a nontraumatic osteoporotic vertebral fracture. SETTING AND INTERVENTIONS: All patients were admitted to the hospital, divided randomly into two groups and received either one calcitonin or placebo suppository once a day, respectively, for 28 days. All patients were allowed to take paracetamol tablets (500 mg), with a maximum dose of six tablets daily. OUTCOME MEASURES: Spinal pain evaluation was performed at the beginning of the study (before the initiation of treatment) and then daily until the end of the study (day 28) using the Huskinsson's visual analog scale (VAS) and a painmeter device, by direct pressure on the fractured vertebra. Pain was evaluated with the patients attempting or performing four different locomotor functions, e.g., bed rest, sitting, standing, and walking functions. Biochemical urine and plasma measurements were carried out before the initiation of treatment and on days 14 and 28. RESULTS: All calcitonin-treated patients experienced an overall statistically significant (all p values < 0.001) decrease of spinal pain as assessed by the VAS and the painmeter device. Pain relief allowed for early mobilization and the gradual restoration of the locomotive functions in the calcitonin-treated group. Placebo-treated patients remained in bed for almost the whole of the observation period. At the end of the study (28th day), fasting osteocalcin, hydroxyproline/creatinine, and calcium/creatinine ratio values were statistically significantly (all p values < 0.001), lower in the calcitonin-treated than in the placebo-treated patients. In the placebo group these values showed a gradual increase. In the calcitonin-treated group side effects mainly included dizziness and enteric irritation caused by the suppositories. Enteric irritation was also present in the placebo-treated group. CONCLUSIONS: Salmon calcitonin suppositories (200 IU daily) caused a dramatic decrease in spinal pain in patients with recent osteoporotic vertebral fractures and influenced the early mobilization and the gradual restoration of their locomotor functions.


Subject(s)
Analgesics/administration & dosage , Calcitonin/administration & dosage , Osteoporosis/complications , Pain/drug therapy , Pain/etiology , Spinal Fractures/etiology , Spinal Fractures/physiopathology , Acute Disease , Aged , Aged, 80 and over , Analgesics/therapeutic use , Calcitonin/therapeutic use , Female , Humans , Male , Middle Aged , Pain Measurement , Placebos , Prospective Studies , Suppositories , Walking
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