ABSTRACT
BACKGROUND: Men with fragile X-associated tremor/ataxia syndrome (FXTAS) often develop executive dysfunction, characterized by disinhibition, frontal dyscontrol of movement, and working memory and attention changes. Although cross-sectional studies have suggested that earlier executive function changes may precede FXTAS, the lack of longitudinal studies has made it difficult to address this hypothesis. OBJECTIVE: To determine whether executive function deterioration experienced by premutation carriers (PC) in daily life precedes and predicts FXTAS. METHODS: This study included 66 FMR1 PC ranging from 40 to 78 years (mean, 59.5) and 31 well-matched healthy controls (HC) ages 40 to 75 (mean, 57.7) at baseline. Eighty-four participants returned for 2 to 5 follow up visits over a duration of 1 to 9 years (mean, 4.6); 28 of the PC developed FXTAS. The Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A) was completed by participants and their spouses/partners at each visit. RESULTS: Longitudinal mixed model regression analyses showed a greater decline with age in PC compared to HC on the Metacognition Index (MI; self-initiation, working memory, organization, task monitoring). Conversion to FXTAS was associated with worsening MI and Behavioral Regulation Index (BRI; inhibition, flexibility, emotion modulation). For spouse/partner report, FXTAS conversion was associated with worsening MI. Finally, increased self-report executive function problems at baseline significantly predicted later development of FXTAS. CONCLUSIONS: Executive function changes experienced by male PC represent a prodrome of the later movement disorder. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Subject(s)
Fragile X Syndrome , Movement Disorders , Adult , Humans , Male , Executive Function/physiology , Tremor , Longitudinal Studies , Cross-Sectional Studies , Fragile X Mental Retardation Protein/genetics , Fragile X Syndrome/genetics , Fragile X Syndrome/complications , Ataxia , Movement Disorders/complicationsABSTRACT
Gamete size variation between the sexes is central to the concept of sex roles, however, to what extent gamete size variation within the sexes relates to sex role variation remains unclear. Comparative and theoretical studies suggest that, when clutch size is invariable, polyandry is linked to a reduction of egg size, while increased female-female competition for mates favors early breeding when females cannot monopolize multiple males. To understand whether and how breeding phenology, egg size, and mating behavior are related at the individual level, we studied the reproductive histories of 424 snowy plover females observed in the wild over a 15-year period. Egg size, but not polyandry, were highly repeatable for individual females. Consistent with theoretical predictions, we found that polyandrous females were the earliest breeders and that early clutches contained smaller eggs than clutches initiated later. Neither egg size nor mating behavior showed clear signs of an age-related deterioration, on the contrary, prior experience acquired either through age or local recruitment enabled females to nest early. Taken together, these results suggest that gamete size variation is not linked to mating behavior at the individual level, and, consequently, the adaptive potential of such variation appears to be limited.
Subject(s)
Reproduction , Sexual Behavior, Animal , Male , Female , Animals , Clutch SizeABSTRACT
Background: Men with fragile X-associated tremor/ataxia syndrome (FXTAS) often develop executive dysfunction, characterized by disinhibition, frontal dyscontrol of movement, and working memory and attention changes. Although cross-sectional studies have suggested that earlier executive function changes may precede FXTAS, the lack of longitudinal studies have made it difficult to address this hypothesis. Methods: This study included 66 FMR1 premutation carriers (PC) ranging from 40-78 years (Mean=59.5) and 31 well-matched healthy controls (HC) ages 40-75 (Mean 57.7) at baseline. Eighty-four participants returned for 2-5 follow up visits over a duration of 1 to 9 years (Mean=4.6); 28 of the PC developed FXTAS. The Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A) was completed by participants and their spouses/partners at each visit. Results: Longitudinal mixed model regression analyses showed a greater decline with age in PC compared to HC on the Metacognition Index (MI; self-initiation, working memory, organization, task monitoring). Conversion to FXTAS was associated with worsening MI and Behavioral Regulation Index (BRI; inhibition, flexibility, emotion modulation). For spouse/partner report, FXTAS conversion was associated with worsening MI. Finally, BRIEF-A executive function problems at baseline significantly predicted later development of FXTAS. Conclusions: These findings suggest that executive function changes represent a prodrome of the later movement disorder.
ABSTRACT
Antecedentes: El SAHOS es una afección respiratoria durante el sueño que constituye un conjunto de signos y síntomas causados por la configuración de algunas estructuras anatómicas del sistema estomatognático, derivando en graves alteraciones sistémicas. En los últimos años, las ramas odontológicas de Ortodoncia y Ortopedia han buscado desarrollar alternativas de tratamiento eficaces para mejorar la calidad de vida de estos pacientes. Objetivo:Describir y resumirlas terapias de ortopedia/ortodoncia para el tratamiento de pacientes con el síndrome de apnea/hipopnea obstructiva del sueño (SAHOS). Materiales y Métodos:Se realizó una búsqueda sistemática en las bases de datos Pubmed, Scielo, Semanthic Scholar y Science Direct de artículos científicos que estudiaron la eficacia de tratamientos ortodóncicos/ortopédicos en pacientes con SAHOS. Se incluyeron estudios en inglés tipo ensayos clínicos controlados publicados en los últimos 5 años. Resultados: Se encontraron en total 83 artículos, de los cuales solo 9 cumplían con los criterios de elegibilidad. Dentro del tratamiento ortodóncico/ortopédico para el SAHOS, se encontaron dispositivo de avance mandibular, terapia de aparatos orales, terapia posicional; algunos implican efectos adversos en ciertos pacientes Conclusión:En las terapias de ortodoncia/ortopedia para el tratamiento del SAHOS se observó que los signos y síntomas mejoraron considerablemente a pesar de presentar efectos adversos.
Background: OSAHS is a respiratory condition during sleep that constitutes a set of signs and symptoms caused by the configuration of some anatomical structures of the stomatognathic system, leading to serious systemic alterations. In recent years, the dental branches of Orthodontics and Orthopedics have sought to develop effective treatment alternatives to improve the quality of life of these patients. Objective:To describe and summarize orthopedic / orthodontic therapies for the treatment of patients with obstructive sleep apnea / hypopnea syndrome (OSAHS). Materials and methods:A systematic search was carried out in the Pubmed, Scielo, Semanthic Scholar and Science Direct databases for scientific articles that studied the efficacy of orthodontic / orthopedic treatments in patients with OSAHS. English-language controlled clinical trials studies published in the last 5 years were included. Results:A total of 83 articles were found, of which only 9 met the eligibility criteria. Within the orthodontic / orthopedic treatment for OSAHS, mandibular advancement device, oral appliance therapy, positional therapy were found; some involve adverse effects incertain patients. Conclusion:In the orthodontic / orthopedic therapies for the treatment of OSAHS, it was observed that the signs and symptoms improved considerably despite presenting adverse effects.
ABSTRACT
The nursing professional who treats critically ill children with cerebral injury is a key element within the pediatric intensive care team, since, through exhaustive assessment, plans nursing care in an integral manner aimed at the child and the family, and plays an essential role in the care of patients mainly at the hospital level (as well as at home). Therefore, the role played by nursing in the care of children with severe brain trauma is crucial. This guide offers nursing recommendations on neurocritical care, focusing on a systemic view based on nursing diagnoses according to the North American Nursing Diagnosis Association.
El profesional de enfermería que atiende a niños críticamente enfermos con lesión cerebral es un miembro clave dentro del equipo intensivista pediátrico, ya que, mediante la evaluación exhaustiva, planifica cuidados de enfermería de manera integral dirigidos al niño y a la familia. La enfermería como una profesión que entiende la salud de la persona humana desde una mirada integral cumple un rol esencial (indispensable) en el cuidado de los pacientes, principalmente, a nivel hospitalario (como domiciliario). Por ende, el rol que juega la enfermería en la atención de un niño con traumatismo encéfalocraneano grave es crucial en la gestión del cuidado infantil. Esta guía ofrece recomendaciones de enfermería sobre los cuidados neurocríticos focalizando una mirada sistémica basada en diagnósticos de enfermería según la Asociación Americana de Diagnósticos de Enfermería.
Subject(s)
Advanced Practice Nursing/standards , Brain Injuries, Traumatic/nursing , Consensus , Critical Care Nursing/standards , Advanced Practice Nursing/methods , Brain Injuries, Traumatic/etiology , Child , Critical Care/organization & administration , Critical Care Nursing/methods , Hospitalization , Humans , Intensive Care Units, PediatricSubject(s)
Aviation , Bariatric Surgery/methods , Endoscopy, Gastrointestinal/instrumentation , Obesity/surgery , Safety , Duodenum , Humans , JejunumABSTRACT
En este trabajo se realizó la evaluación toxicológica a dosis repetidas por el método de test límite del candidato ainmunopotenciador, la solución CM-95 tratada magnéticamente, acorde con las regulaciones de la Organización para la Colaboración Económica y el Desarrollo, incluida en la Guía 407. El objetivo fue establecer las posibles lesiones orgánicas y funcionales ocasionadas por la solución CM-95, tratada magnéticamente con la máxima inducción magnética permisible (0,16 T), para la obtención del candidato a inmunopotenciador. Se emplearon tres grupos: Experimental, Control y Satélite. Como Biomodelo experimental se utilizaron ratas Sprague Dawley machos y hembras con pesos de 150 a 200 g. Durante el estudio no se registraron signos clínicos de toxicidad ni muertes en ninguno de los animales de los grupos tratados, ni en los controles. No hubo afectación del peso corporal durante elensayo. Aunque hubo variaciones en los valores de algunos parámetros hematológicos y bioquímicos, estos no tuvieron significación biológica. No se encontraron lesiones macroscópicas, ni microscópicas; solo se observaron efectos proliferativos en el tejido linfoide de timo y bazo, relacionados con la respuesta del sistema inmune. Lasolución CM-95 tratada magnéticamente, no mostró toxicidad en el modelo animal y nivel de dosis utilizado, y bajo las condiciones experimentales ensayadas(AU)
In this study the toxicological evaluation at repeated dose by the method of limit test of the candidate to magnetically treated immunopotentiator CM-95 Solution was carried out; according with regulations of the Organization for Economic Cooperation and Development included in guide 407. The objective was to establish the possible organic and functional lesions caused bythe magnetically treated CM-95 Solution with maximum permissible magnetic induction (0,16 T), for obtaining the candidate to immunopotentiator. Three groups were used: Experimental, Control and Satellite. As experimental Biomodels, male and female Sprague Dawley rats were used, with 150 to 200 g weights. During the study neither clinical signs of toxicity nor deathsin any of the animals of the treated groups were registered. There was not affectation of the corporal weight during the test. There was not change of the corporal weight during the trial. Although there were variations of some haematology and biochemical parameters, they had no biological significance. Macroscopic or microscopic lesions were not found; justproliferation effects were observed, in the lymphoid tissues of the thymus and spleen, related to the response of immune system. Magnetically treated CM-95 Solution, showed no toxicity in the animal model and dose level used, and under the observed experimental conditions(AU)
