ABSTRACT
ABSTRACT: Mycosis fungoides (MF) has become one of the most difficult diagnostic challenges for both dermatologists and dermatopathologists because its clinical presentation and microscopic findings may mimic benign reactive processes, specifically those displaying histopathological features of interface dermatitis. The goal of our study was to prove with digital scanning and automated sample methodology through algorithmic analysis, combined with the utility of TOX marker a more precise, faster, and objective evaluation of each sample. Moreover, this would offer high levels of reproducibility with the possibility of establishing cut-off points, allowing us to distinguish between inflammatory dermatoses (ID) and MF. A retrospective longitudinal-descriptive and observational study was conducted to compare the diagnostic criteria (immunohistochemical studies of anti-TOX stain) in patients with clinical suspicion of MF by dividing them into 2 groups: samples with a positive biopsy for MF (MF group) and those with a negative biopsy, therefore diagnosed as an ID (control group). The algorithm assessed 5 selected areas with lymphocytic representative cellularity, and based on the intensity, nuclear staining was classified as 0 (negative), 1+ (weak/yellow), 2+ (moderate/orange), and 3+ (strong/scarlet red) nuclei. The results showed statistically significant differences ( P = 0.040) between the mean number of (2+) nuclei in the positive final diagnosis group (MF group) and the negative final diagnosis group (ID group).
Subject(s)
Dermatitis , Mycosis Fungoides , Skin Neoplasms , Humans , Retrospective Studies , Skin Neoplasms/diagnosis , Skin Neoplasms/pathology , Reproducibility of Results , Mycosis Fungoides/diagnosis , Mycosis Fungoides/pathology , Lymphocytes/pathology , Dermatitis/pathologyABSTRACT
Introducción: la fibrosis pulmonar idiopática (FPI) es una enfermedad progresiva y cró-nica con muy mal pronóstico. Actualmente, existen dos fármacos para esta patología. El propósito de nuestro estudio es evaluar los efectos del tratamiento en los pacientes de una consulta en vida real.
Introduction: idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease with a very poor prognosis. Two drugs are currently available for this disease. The purpo-se of our study is to evaluate the effects of treatment in patients in a real-life practice.
Subject(s)
Humans , Male , Female , Aged , Dyspnea , Idiopathic Pulmonary Fibrosis/drug therapy , Antifibrotic Agents/therapeutic use , Respiratory Function Tests , Efficacy , Drug ToleranceABSTRACT
Antecedentes: En la sociedad actual, la halitosis es motivo de preocupación creciente de los pacientes, los cuales demandan a sus profesionales soluciones terapéuticas para el tratamiento de esta entidad de etiología multifactorial. Los compuestos sulfurados volátiles, originados, fundamentalmente, por las bacterias anaerobias gram negativas e la microbiota oral, son los principales responsables de mal olor oraObjetivo: Realizar una revisión yactualización de la evidencia científica respecto a los principales componentes activos de los enjuagues orales empleados para el tratamiento de la halitosis intraoral Material y método: Se realizó una búsqueda bibliográfica en las bases de datos: Medline/PubMed, Cochrane Library, Scopus y Web of Science empleando los términos de búsqueda: Halitosis AND mouthwash OR mouthrinse hasta Julio del 2021.Conclusión: La eficacia de los colutorios para el tratamiento de la halitosis dependerá del tipo de principio activo, o la combinación de ellos, de la formulación, así como, de la realización de un correcto diagnóstico etiológico (AU)
