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1.
Headache ; 46(6): 983-90, 2006 Jun.
Article in English | MEDLINE | ID: mdl-16732844

ABSTRACT

OBJECTIVE: The present study examined the relationship between the diagnosis of migraine and self-reported sexual desire. BACKGROUND: There is evidence for a complex relationship between sexual activity and headache, particularly migraine. The current headache diagnostic criteria even distinguish between several types of primary headaches associated with sexual activity. METHODS: Members of the community or students at the Illinois Institute of Technology (N = 68) were administered the Brief Headache Diagnostic Interview and the Sexual Desire Inventory (SDI). Based on the revised diagnostic criteria established by the International Headache Society (ICHD-II), participants were placed in 1 of the 2 headache diagnostic groups: migraine (n = 23) or tension-type (n = 36). RESULTS: Migraine subjects reported higher SDI scores, and rated their own perceived level of desire higher than those suffering from tension-type headache. The presence of the symptom "headache aggravated by routine physical activity" significantly predicted an elevated SDI score. CONCLUSIONS: Migraine headaches and sexual desire both appear to be at least partially modulated by serotonin (5-HT). The metabolism of 5-HT has been shown to covary with the onset of a migraine attack, and migraineurs appear to have chronically low systemic 5-HT. As sexual desire also has been linked to serotonin levels, the results are consistent with the hypothesis that migraine and sexual desire both may be modulated by similar serotonergic phenomena.


Subject(s)
Migraine Disorders/physiopathology , Sexual Behavior/physiology , Sexuality/physiology , Adolescent , Adult , Female , Humans , Male , Motor Activity/physiology , Serotonin/physiology , Sex Characteristics , Tension-Type Headache/physiopathology
2.
Appl Psychophysiol Biofeedback ; 28(3): 205-15, 2003 Sep.
Article in English | MEDLINE | ID: mdl-12964452

ABSTRACT

The effectiveness of EMG biofeedback training for tension headache has been well established. Previous studies evaluating changes in an average EMG activity score from pre- to posttreatment have not consistently found a relationship between a reduction in average EMG activity and headache improvement at posttreatment. The current study is a preliminary analysis of the utility of EMG variance as another possible mechanism of change. Frontalis EMG average activity and variances from 6 chronic tension-type headache sufferers who demonstrated significant improvement in headache activity at posttreatment (at least 70%) and 6 chronic tension-type headache sufferes who did not demonstrate improvement (less than 30%) were examined across 6 sessions of biofeedback treatment. The improved group demonstrated larger time-specific EMG variance in relation to mean EMG amplitudes during all treatment sessions. A dramatic decline in time-specific variance was observed during the later treatment sessions for improved participants; this pattern was not observed in the group who demonstrated little or no improvement. Results from the current study suggest that the inclusion of both average EMG activity and EMG variance may provide a more comprehensive measure to evaluate possible physiological changes responsible for improvement in headache activity following EMG biofeedback training.


Subject(s)
Biofeedback, Psychology , Tension-Type Headache/psychology , Tension-Type Headache/therapy , Adolescent , Adult , Electromyography , Endpoint Determination , Female , Humans , Male , Reproducibility of Results , Treatment Outcome
3.
Psychopharmacology (Berl) ; 161(3): 213-21, 2002 May.
Article in English | MEDLINE | ID: mdl-12021824

ABSTRACT

RATIONALE: Critics have called into question findings from double-blind placebo-controlled studies because subjects are given drug administration instructions informing them of a placebo condition. The assertion that these drug administration instructions bias estimates of effectiveness has undergone surprisingly little empirical investigation. OBJECTIVES: The primary objective of this study was to determine whether drug administration instructions informing subjects of a placebo condition affect the drug response and affect the saliva concentration of the stimulant. METHODS: We assessed caffeine responses and levels of saliva concentration of caffeine in 52 subjects who were randomly assigned to receive one of two drug administration instructions: (a) placebo-informed instructions (i.e., individuals informed of the placebo) analogous to those used in double-blind studies and (b) placebo-uninformed instructions (i.e., individuals informed they are taking an active stimulant). RESULTS: On most measures (systolic blood pressure, heart rate, hand steadiness, reaction time, fatigue, and tension), drug administration instructions did not significantly influence caffeine response. Instructions also had no significant effect on saliva concentration of caffeine. However, only individuals who were uninformed of the placebo condition showed significant diastolic blood pressure and vigor increases with 125 mg caffeine, and significant hand steadiness impairment and vigor increases with 325 mg caffeine compared to placebo. CONCLUSIONS: These overall findings suggest that a limited bias is introduced by drug administration instructions. The results do not support any suggestion that information about the existence of a placebo condition dramatically influences conclusions drawn about drug responses in placebo-controlled trials.


Subject(s)
Caffeine/pharmacology , Central Nervous System Stimulants/pharmacology , Placebos/administration & dosage , Affect/drug effects , Analysis of Variance , Blood Pressure/drug effects , Caffeine/pharmacokinetics , Central Nervous System Stimulants/pharmacokinetics , Dose-Response Relationship, Drug , Double-Blind Method , Female , Hand/physiology , Humans , Male , Psychomotor Performance/drug effects , Reaction Time , Saliva/drug effects , Saliva/metabolism
4.
Pain ; 64(3): 467-475, 1996 Mar.
Article in English | MEDLINE | ID: mdl-8783311

ABSTRACT

The second exteroceptive suppression of masseter muscle activity (ES2) and tenderness in pericranial muscles were evaluated in 112 young adults who met IHS criteria in the following diagnostic classifications: 31 chronic tension headache, 31 episodic tension headache, 33 migraine without aura and 17 migraine with aura. An additional 31 subjects served as controls. Pericranial muscle tenderness better distinguished diagnostic subgroups and better distinguished recurrent headache sufferers from controls than did masseter ES2. Chronic tension headache sufferers exhibited the highest pericranial muscle tenderness, and controls exhibited the lowest tenderness (P < 0.01). All chronic tension headache sufferers exhibited muscle tenderness in at least one of the pericranial muscles evaluated, while tenderness was exhibited by 52% of controls. The association between pericranial muscle tenderness and chronic tension headache was independent of the intensity, frequency, or chronicity of headaches. Our findings raise the possibility that pericranial muscle tenderness is present early in the development of tension headache, while ES2 suppression only emerges later in the evolution of the disorder.


Subject(s)
Central Nervous System/physiopathology , Peripheral Nervous System/physiopathology , Tension-Type Headache/physiopathology , Adult , Chronic Disease , Electric Stimulation , Electromyography , Female , Humans , Masseter Muscle/innervation , Masseter Muscle/physiopathology , Migraine Disorders/complications , Migraine Disorders/physiopathology , Muscle, Skeletal/physiopathology , Recurrence
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