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1.
Br J Hosp Med (Lond) ; 84(4): 1-10, 2023 Apr 02.
Article in English | MEDLINE | ID: mdl-37127417

ABSTRACT

Skin cancer is the most common malignancy in the world, and the majority of cases affect the skin of the head and neck. The face is a particularly emotive area for patients who often present with a lesion that is causing them concern. This article reviews the identification, diagnosis and principles of management of non-melanoma skin cancer of the head and neck. There are many lesions of the skin which are benign and mimic skin cancer. The differential of head and neck skin lesions and how to determine their nature is discussed. The vast majority of non-melanoma skin cancer are basal cell carcinoma, followed by squamous cell carcinoma. These and the other types of non-melanoma skin cancer are described and illustrated. Current methods of clinical identification, diagnosis and evaluation of skin cancers are clarified, and contemporary treatment paradigms are presented.


Subject(s)
Carcinoma, Basal Cell , Carcinoma, Squamous Cell , Head and Neck Neoplasms , Skin Neoplasms , Humans , Skin Neoplasms/pathology , Carcinoma, Basal Cell/pathology , Carcinoma, Squamous Cell/diagnosis
3.
Ann Surg Oncol ; 29(12): 7881-7890, 2022 Nov.
Article in English | MEDLINE | ID: mdl-35842533

ABSTRACT

Retropharyngeal metastases are encountered in a variety of head and neck malignancies, imposing significant surgical challenges owing to their distinct location and proximity to neurovascular structures. Radiotherapy is the recommended treatment in most cases owing to its oncological efficacy. However, retropharyngeal irradiation affects the superior pharyngeal constrictor muscles and parotid glands, with the potential for long-term dysphagia and xerostomia. A younger oropharyngeal and thyroid cancer patient demographic is trending, fueling interest in treatment de-escalation strategies. Consequently, reducing radiotoxicity and its long-term effects is of special relevance in modern head and neck oncology practice. Through its unique ability to safely extirpate these traditionally difficult-to-access retropharyngeal lymph nodes via a natural orifice, TransOral Robotic Surgery (TORS) can considerably lower the surgical morbidity of retropharyngeal lymph node dissection (RPLND), compared with current existing approaches. This review summarizes the latest developments in the field, exposing current research gaps and discusses specific clinical settings where TORS could enable treatment de-escalation. In early-stage node-negative oropharyngeal cancer, single-modality surgical treatment with TORS RPLND may improve risk stratification of metastasis and recurrence in this region. TORS RPLND is also a potentially viable treatment option in salvage of an isolated retropharyngeal node recurrence or in the primary setting of a thyroid malignancy with a single positive retropharyngeal node. In time, TORS RPLND may provide an alternative de-escalation strategy in these three scenarios. However, with the reported morbidities, further prospective trials with long-term follow-up data are required to prove oncological safety and functional benefits over existing strategies.


Subject(s)
Head and Neck Neoplasms , Oropharyngeal Neoplasms , Robotic Surgical Procedures , Thyroid Neoplasms , Head and Neck Neoplasms/pathology , Humans , Lymph Nodes/pathology , Lymph Nodes/surgery , Lymphatic Metastasis/pathology , Oropharyngeal Neoplasms/pathology , Oropharyngeal Neoplasms/surgery , Thyroid Neoplasms/pathology , Thyroid Neoplasms/surgery
4.
Eur Arch Otorhinolaryngol ; 277(3): 947-952, 2020 Mar.
Article in English | MEDLINE | ID: mdl-31915919

ABSTRACT

PURPOSE: A multidisciplinary team (MDT) approach to cancer management is gold-standard. With an increasing disease incidence and growing research into human papillomavirus (HPV)-related oropharyngeal cancer (OPC), updated UK management guidelines were recently published. This study aimed to evaluate the MDT decision-making process among OPC patients at a tertiary centre. METHODS: MDT meetings over a 12-month period were analysed retrospectively. MDT decisions were compared with guidelines and patient records examined to identify decision implementation. Reasons behind any discordant decisions were explored. RESULTS: This study included 140 OPC patients. Thirty-three (23.6%) were not tested for HPV. Patients over 70 years with a smoking history treated palliatively were less likely to be tested (P = 0.017). Eighty-five percent of MDT decisions followed guidelines with the majority not complying (76.2%) related to patient comorbidity. Ten decisions (7.1%) were not implemented. Reasons included: Seven due to patient choice, of which four patients (57.1%) were only seen following the MDT meeting, and three due to clinician decisions as new clinical information emerged. CONCLUSION: The majority of MDT decisions followed guidelines and any discordant decisions were justifiable. Discussing management options with patients beforehand facilitates decision implementation as decisions can potentially change after seeing the patient. Progress is still needed with regards to HPV testing. Reasons for not testing could include subliminal decision-making among clinicians, and patients falling between centres. Crucially, the role of the MDT in head and neck cancer should be to ratify decisions rather than making them, hence the need to see patients prior to MDT discussion.


Subject(s)
Oropharyngeal Neoplasms , Patient Care Team , Decision Making , Humans , Oropharyngeal Neoplasms/diagnosis , Oropharyngeal Neoplasms/therapy , Patient Selection , Retrospective Studies
5.
Arch Pathol Lab Med ; 143(4): 432-438, 2019 04.
Article in English | MEDLINE | ID: mdl-30500292

ABSTRACT

The International Collaboration on Cancer Reporting is a nonprofit organization whose mission is to develop evidence-based, universally available surgical pathology reporting data sets. Standardized pathologic reporting for cancers facilitates improved communication for patient care and prognosis and the comparison of data between countries to progressively improve clinical outcomes. Laryngeal cancers are often accompanied by significant morbidity, although surgical advances (such as transoral endoscopic laser microresection and transoral robotic surgery) provide new alternatives. The anatomy of the larynx is complex, with an understanding of the exact anatomic sites and subsites, along with recognizing anatomic landmarks, being crucial to classification and prognostication. This review outlines the data set developed for the histopathology reporting in Carcinomas of the Hypopharynx, Larynx and Trachea and discusses the main elements required and recommended for reporting.


Subject(s)
Datasets as Topic , Hypopharyngeal Neoplasms/pathology , Laryngeal Neoplasms/pathology , Practice Guidelines as Topic , Squamous Cell Carcinoma of Head and Neck/pathology , Tracheal Neoplasms/pathology , Datasets as Topic/standards , Humans , Pathology, Clinical/standards , Research Design/standards
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