ABSTRACT
No disponible
Subject(s)
Humans , Attention Deficit Disorder with Hyperactivity/complications , /complications , Risk Factors , Growth Disorders/etiologyABSTRACT
Addison's disease or primary adrenal insufficiency is a rare disease in children. The signs and symptoms at diagnosis are frequently non-specific and insidious. Since adrenal crisis represents an emergency, it is important to be aware and to have a high degree of suspicion of the disorder in order to achieve an early diagnosis and treatment. We present a retrospective study describing the epidemiological, clinical and etiological data at diagnosis of five patients with Addison's disease followed up in our hospital. Dehydration, hyponatremia and skin hyperpigmentation were the most prevalent signs and symptoms at onset of the disease. The patients had low serum cortisol levels and positive adrenal antibodies. One patient with negative antibodies presented with a polyglandular syndrome.
Subject(s)
Addison Disease/diagnosis , Child , Child, Preschool , Humans , Male , Retrospective StudiesABSTRACT
No disponible
Subject(s)
Humans , Female , Infant, Newborn , Adrenal Hyperplasia, Congenital/genetics , Steroid 21-Hydroxylase/analysis , Genetic Counseling , Mixed Function Oxygenases/deficiencySubject(s)
Adrenal Hyperplasia, Congenital/genetics , Genetic Counseling , Female , Humans , Infant, Newborn , PedigreeSubject(s)
Hypopituitarism/congenital , Anodontia/diagnosis , Humans , Hypopituitarism/diagnosis , Incisor/abnormalities , Infant, Newborn , Male , SyndromeABSTRACT
Los avances en el tratamiento de la diabetes mellitus tipo 1 han permitido que el desarrollo puberal y la talla final de las niñas y adolescentes con diabetes sean normales aun cuando puedan presentar un discreto retraso en el inicio y la progresión de la telarquia y en la edad de la menarquía. El hirsutismo y las irregularidades menstruales, síntomas asociados al hiperandrogenismo, son identificados con frecuencia y la prevalencia de hiperandrogenismo y de síndrome de ovario poliquístico son mayores en las adolescentes y mujeres con diabetes tipo 1 que en las poblaciones control. Se ha sugerido que el uso de insulina exógena a dosis suprafisiológicas en el tratamiento de la diabetes tipo 1 pueda contribuir al desarrollo del hiperandrogenismo, especialmente por la administración de la insulina por una vía no fisiológica, como es la subcutánea. Por ello resulta obligatoria la identificación de los ´síntomas y signos relacionados con el hiperandrogenismo en el grupo de mujeres con diabetes tipo 1 controladas en nuestras consultas y la introducción de hábitos de vida saludables y la prevención del sobrepeso con objeto de evitar la insulinorresistencia y la utilización de dosis excesivas de insulina en las adolescentes y mujeres jóvenes (AU)
Type 1 diabetic girls and adolescents present with a normal final height and pubertal development due to major advances in the treatment of their disease. However, a mild delay in the age of thelarche and menarche is still observed in some girls with type 1 diabetes. Hirsutism and menstrual disturbances, which are symptoms related to hyperandrogenism, are frequent and prevalences of hyperandrogenism, are frequent and prevalences of hyperandrogenism and polycystic ovary syndrome are higher in adolescents and young type 1 diabetic women compared with control populations. It has been suggested that the use for supraphysiological doses of exogenous insulin to treat type 1 diabetes might contribute to the development of hyperandrogenism in these patients, especially since insulin is delivered though a non-physiological route such as subcutaneous injection. Therefore, early identification of the symptoms and signs associated with hyperandrogenism is mandatory in the follow-up of type 1 diabetic patients. Healthy life-style recommendations and preventing of weight gain are needed in order to prevent insulin resistance and the use of excessive doses of insulin in the treatment of adolescents and young women (AU)
Subject(s)
Humans , Female , Child , Adolescent , Diabetes Mellitus, Type 1/complications , Hyperandrogenism/epidemiology , Hirsutism/epidemiology , Menstruation Disturbances/epidemiology , Polycystic Ovary Syndrome/epidemiology , Insulin/administration & dosageABSTRACT
OBJECTIVE: Girls diagnosed of type 1 diabetes mellitus during the prepubertal stage may present reduced longitudinal growth and have a tendency to be overweight after puberty starts. Our objective was to evaluate the growth, pubertal growth spurt, final height and weight gain of diabetic girls diagnosed of insulin dependent diabetes during the prepubertal period. PATIENTS AND METHODS: We evaluated retrospectively the longitudinal growth and body mass index (BMI) of 17 girls diagnosed of type 1 diabetes before puberty, from the time of diagnosis until final height. The effects of age at diagnosis, evolution time, insulin therapy (conventional or intensified), insulin dose and metabolic control on growth were analyzed. RESULTS: The final height attained was 161 +/- 4 cm, which is within the target height range. The height at diagnosis (0.31 +/- 0.71) was normal in relationship to the reference population, showing a significant reduction upon reaching the final height (-0.18 +/- 0.77). The BMI was significantly increased when it was compared at final height (0.99 +/- 0.79) with the index obtained one year after the onset of diabetes (0.04 +/- 0.63). The insulin therapy regimen did not affect the evolution of the patients and no significant relationship existed between the age at diagnosis, duration of diabetes, daily insulin dosage or metabolic control and height or BMI. CONCLUSIONS: The final height of type 1 diabetic girls is reduced and adolescent diabetic girls have a tendency to be overweight. Metabolic control (for the range observed in these patients) or insulin dosage does not seem to affect the growth of diabetic girls.
Subject(s)
Body Height/physiology , Child Development/physiology , Diabetes Mellitus, Type 1/diagnosis , Puberty/physiology , Weight Gain/physiology , Anthropometry , Body Mass Index , Child , Female , Humans , Retrospective StudiesABSTRACT
Intestinal permeability was studied in a group of 10 children diagnosed of coeliac disease either when they presented an intestinal villi atrophy while receiving a gluten-containing diet and after, when they had a normal mucosa with the withdrawal of gluten from the diet. Ten healthy children served as controls. The 51 Cr-EDTA (51 Cr-ethylenediaminetetraacetate) was used as probe molecule and it was administered orally. Its urinary excretion showed clear differences between patients with an altered intestinal biopsy and those with a normal histopathology. The excretion of 51 Cr-EDTA remained elevated in celiac patients with a gluten-free diet and normal villi.
Subject(s)
Celiac Disease/physiopathology , Edetic Acid/pharmacokinetics , Glutens/administration & dosage , Intestinal Absorption , Administration, Oral , Biopsy , Case-Control Studies , Celiac Disease/metabolism , Child , Child, Preschool , Diet , Edetic Acid/administration & dosage , Edetic Acid/analysis , Female , Humans , Intestinal Mucosa/pathology , MaleABSTRACT
Presentamos un estudio sobre la permeabilidad intestinal en una serie de diez niños diagnosticados de enfermedad celiaca cuando tomaban una dieta con gluten y tenían una atrofia severa de las vellosidades intestinales y posteriormente durante un período con dieta sin gluten y vellosidades intestinales normales. Tomamaos como grupo control a diez niños sanos. Se utilizó como marcador el EDTA-Cr51 (Etiléndiaminotetracetato Cr51) administrado por vía oral. Su excreción urinaria estaba signficativamente elevada en los pacientes con biopsia alterada, manteniéndose una moderada elevación en los pacientes celiacos con dieta exenta de gluten y sin atrofia de las vellosidades
Subject(s)
Humans , Male , Female , Child, Preschool , Child , Intestinal Absorption , Edetic Acid/administration & dosage , Celiac Disease/complications , Glutens/administration & dosage , Edetic Acid/analysis , Administration, Oral , Biopsy , Case-Control Studies , Diet , Intestinal Mucosa/pathologyABSTRACT
Intestinal permeability was studied in a group of 10 children diagnosed of coeliac disease either when they presented an intestinal villi atrophy while receiving a gluten-containing diet and after, when they had a normal mucosa with the withdrawal of gluten from the diet. Ten healthy children served as controls. The 51 Cr-EDTA (51 Cr-ethylenediaminetetraacetate) was used as probe molecule and it was administered orally. Its urinary excretion showed clear differences between patients with an altered intestinal biopsy and those with a normal histopathology. The excretion of 51 Cr-EDTA remained elevated in celiac patients with a gluten-free diet and normal villi.
ABSTRACT
Presentamos un estudio sobre la permeabilidad intestinal en una serie de diez niños diagnosticados de enfermedad celiaca cuando tomaban una dieta con gluten y tenían una atrofia severa de las vellosidades intestinales y posteriormente durante un período con dieta sin gluten y vellosidades intestinales normales. Tomamaos como grupo control a diez niños sanos. Se utilizó como marcador el EDTA-Cr51 (Etiléndiaminotetracetato Cr51) administrado por vía oral. Su excreción urinaria estaba signficativamente elevada en los pacientes con biopsia alterada, manteniéndose una moderada elevación en los pacientes celiacos con dieta exenta de gluten y sin atrofia de las vellosidades (AU)
