ABSTRACT
PURPOSE: To evaluate the frequency and the consequences of the co-infection of hepatitis B and C viruses in patients with hepatosplenic schistosomiasis (HSS). METHODS: B and C serologic markers, exposure to risk factors, biochemical assays, upper gastrointestinal endoscopies, and abdominal ultrasonograms were evaluated in 101 patients with HSS from 1994 to 1997. Whenever possible, PCR was tested and histopathological studies were reviewed. RESULTS: At least one HBV virus marker was found in 15.8%, and anti-HCV was detected in 12.9% of the subjects. The seropositive subjects tended to be older than the seronegative ones. A history of blood transfusion was significantly related to the presence of anti-HCV. Three (18.75%) out of 16 subjects exposed to B virus were HBsAg positive. Eleven (84.6%) out of thirteen patients who were anti-HCV positive demonstrated viral activity. Patients with ongoing viral infection presented a higher average level of liver aminotransferases, a higher frequency of cell decompensation and a higher rate of chronic hepatitis. Portal hypertension parameters were not influenced by viral exposure. CONCLUSIONS: The rate of hepatitis B and C viruses serologic markers observed in the patients with HSS was higher than the control group. The co-infection was responsible for a higher frequency of cell decompensation.
Subject(s)
Hepatitis B Antibodies/blood , Hepatitis C Antibodies/blood , Schistosomiasis mansoni/immunology , Splenic Diseases/immunology , Adult , Aged , Biomarkers/blood , Case-Control Studies , Chi-Square Distribution , Female , Hepatitis B/complications , Hepatitis B/immunology , Hepatitis C/complications , Hepatitis C/immunology , Humans , Male , Middle Aged , Risk Factors , Schistosomiasis mansoni/complications , Splenic Diseases/complications , Splenic Diseases/parasitology , Statistics, NonparametricSubject(s)
Home Nursing , Parenteral Nutrition , Body Weight , Catheterization/adverse effects , Humans , Male , Middle Aged , Thrombosis/etiology , Water-Electrolyte BalanceABSTRACT
An isolated rat liver perfusion model was used to study the effects of acute exposure of the organ to either ethanol or a molasses distillate (cachaça). When ethanol (72 mM) or a molasses distillate (68 mM ethanol) was added to the perfusion fluid, lysosomal injury was indicated by the increased release of tartrate-inhibited acid phosphatase activity at the end of a 3 h period of perfusion. Other cellular compartments were not significantly damaged in these acute experiments, as judged by the release of aspartate and alanine aminotransferases, lactate dehydrogenase and alkaline phosphatase. The behavior of both ethanol itself and the alcoholic beverage was similar as far as enzyme release is concerned but only the molasses distillate caused significant acidosis (a decrease in perfusate pH) at the end of a 3 h period of perfusion. These data may be of importance for a better understanding of the hepatic damage caused by alcohol abuse and useful for laboratory investigation of alcohol intoxication.
Subject(s)
Alcoholic Intoxication/pathology , Liver/pathology , Lysosomes/drug effects , Molasses/toxicity , Alkaline Phosphatase/metabolism , Animals , Humans , Lysosomes/enzymology , Perfusion , Rats , Rats, Inbred StrainsABSTRACT
A nutricao parenteral tem ganho campo de aplicacao cada vez maior e seu emprego a domicilio, de forma temporaria ou definitiva, tem permitido manter adequadamente o estado nutricional de doentes impossibilitados da utilizacao do trato digestivo.Neste artigo, sao discutidas as indicacoes os aspectos tecnicos e as complicacoes da nutricao parenteral domiciliar e apresentados dois doentes que se beneficiaram desse metodo
Subject(s)
Middle Aged , Humans , Male , Parenteral Nutrition , Home NursingABSTRACT
As doencas intestinais inflamatorias se acompanham com frequencia de estados de deplecao nutricional. Inumeros sao os fatores que levam a desnutricao. O advento da nutricao parenteral modificou a evolucao e a perspectiva de tratamento deste tipo de afeccao. Neste trabalho, com apresentacao de pequena casuistica, e ressaltado o importante papel da nutricao venosa como metodo coadjuvante na terapeutica da doenca inflamatoria intestinal
