[Maternal non-diagnosed celiac disease and risk of low birth weight]. / Enfermedad celiaca materna no diagnosticada y riesgo de tener hijos con bajo peso al nacimiento.

AIMS: In order to know the prevalence of celiac disease in mothers with newborns weighing less or more than 2,500 g at birth we carried out a case-control study. PATIENTS: mothers of newborns in Cabueñes Hospital. Case group: Mothers with babies weighing less than 2,500 g at birth. CONTROLS: Mothers with babies weighing more than 2,500 g at birth. One control for each case. METHODS: epidemiological and clinical interviews, and celiac disease serology. RESULTS: We studied 1103 women: 577 cases and 526 controls. We diagnosed 4 celiac disease cases, 2 in the case group and 2 in the control group. These 4 mothers had 3 term newborns (1 case in each 235 mothers; prevalence 0.42%) and 1 preterm newborn (1 case in each 389 mothers; prevalence 0.26%). Two cases had babies with adequate birth weight for their gestational age (1 case in each 419 mothers; prevalence 0.24%) and two cases had babies with low birth weight for their gestational age (1 in each 132 mothers; prevalence 0.75%). The odds ratio for low birth weight was 0.91 (95% CI: 0.12-6.49), the odds ratio for preterm birth was 0.61 (95% CI: 0.06-5.89), ad the odds ratio for low birth weight for gestational age was 3.19 (95% CI: 0.44-22.79). CONCLUSIONS: The prevalence of celiac disease in fertile women in our geographic area was 0.36% (1 case in each 275 mothers), and no differences were found between study groups.

Enfermedad celiaca materna no diagnosticada y riesgo de tener hijos con bajo peso al nacimiento / No disponible

Objetivo: conocer la prevalencia de enfermedad celiaca enmadres de neonatos mayores y menores de 2.500 gramos depeso al nacimiento.Pacientes: sujetos: casos: madres de neonatos menores de2.500 g al nacimiento. Controles: madres de neonatos mayoresde 2.500 g al nacimiento. Un control por cada caso. Instrumentalización:encuesta clínico-epidemiológica y serología celiaca.Métodos: estudio caso-control. Ámbito: mujeres del Área SanitariaV (Gijón) del Principado de Asturias que den a luz en elHospital de Cabueñes.Resultados: se analizaron 1.103 mujeres: 577 madres de niñosmenores de 2.500 g y 526 madres de niños mayores de 2.500 g.Se diagnosticaron 4 casos de celiaquía, 2 en cada grupo. De las 4madres, 3 dieron a luz a niños a término (1 caso cada 235 madres,prevalencia 0,42%) y 1 dio a luz a un niño prematuro (1 caso cada389 madres, prevalencia 0,26%). Dos madres dieron a luz a niñosde peso adecuado para su edad gestacional (1/419 madres, prevalencia0,24%) y 2 madres dieron a luz niños de bajo peso para suedad gestacional (1/132 madres, prevalencia 0,75%). La odds ratiopara peso menor de 2.500 g al nacimiento fue 0,91 (IC 95% 0,12-6,49), para prematuridad 0,61 (IC 95% 0,06-5,89) y para bajo pesopara su edad gestacional 3,19 (0,44-22,79).Conclusiones: la prevalencia de enfermedad celiaca en mujeresfértiles de Gijón es de un caso cada 275 madres (prevalencia0,36%), sin que hayamos encontrado diferencias entre los dosgrupos estudiados

Aims: in order to know the prevalence of celiac disease inmothers with newborns weighing less or more than 2,500 g atbirth we carried out a case-control study.Patients: mothers of newborns in Cabueñes Hospital. Casegroup: Mothers with babies weighing less than 2,500 g at birth.Controls: Mothers with babies weighing more than 2,500 g atbirth. One control for each case.Methods: epidemiological and clinical interviews, and celiacdisease serology.Results: we studied 1103 women: 577 cases and 526 controls.We diagnosed 4 celiac disease cases, 2 in the case groupand 2 in the control group. These 4 mothers had 3 term newborns(1 case in each 235 mothers; prevalence 0.42%) and 1preterm newborn (1 case in each 389 mothers; prevalence0.26%). Two cases had babies with adequate birth weight for theirgestational age (1 case in each 419 mothers; prevalence 0.24%)and two cases had babies with low birth weight for their gestationalage (1 in each 132 mothers; prevalence 0.75%). The odds ratiofor low birth weight was 0.91 (95% CI: 0.12-6.49), the odds ratiofor preterm birth was 0.61 (95% CI: 0.06-5.89), ad the odds ratiofor low birth weight for gestational age was 3.19 (95% CI: 0.44-22.79).Conclusions: the prevalence of celiac disease in fertilewomen in our geographic area was 0.36% (1 case in each 275mothers), and no differences were found between study groups

[Hepatotoxicity induced by cyanamide. A review of the anatomicopathological changes apropos a case]. / Hepatotoxicidad inducida por cianamida. Revisión de las alteraciones anatomopatológicas a propósito de un caso.

A case of toxic liver disease induced by cyanamide in a patient in treatment with this drug during 18 months, is presented. We reviewed the different liver cell alterations produced by a long-term treatment with cyanamide, which produces fibrosis and portal inflammation, as well as polished cells with different characteristic features. These alterations forced the establishing of close controls of patients in treatment with this type of anti-alcoholism drug, as well as the reduction of the duration of therapy, this questioning the efficacy of the treatment of chronic alcoholism with this aversive drug.