Usability of Visiting Routes in Heritage: The Case Study of Mercati di Traiano.

Large museums as services to the community, can be considered strategic facilities needing exploitation after the health emergency. Through optimising usability, some methodologies and tools taken from other building uses (hospitals, airports) for analysing users and flows seem effective in testing new spaces' uses. The case study of Mercati Traianei-Museo dei Fori Imperiali was investigated in two different periods and methods for comparing the impacting factors on usability and orientation of visiting routes. A direct analysis in 2015 detected crucial issues for walking through museum routes and connections, while a more recent indirect analysis went deeper through configurational methodologies included in the Spatial Decision Support System (SDSS). This methodology empowers analysis of the space syntax, and the factors affecting the visitors' satisfaction. The two methods were found to be effective for a deeper knowledge of the museum and its priorities. Tools of direct on-site observation are essential to promptly identify obstacles for upgrading usability. Instead, the configurational analysis allows a much faster application and supports a more global and dynamic vision of more inclusive visiting routes, avoiding visitors' stigmatisation.

Model studies on the synthesis of madangamine alkaloids. Assembly of the macrocyclic rings.

Using simplified model derivatives, the assembly of the macrocyclic rings of madangamines, including the 13- and 14-membered D rings of madangamines C-E, the all-cis-triunsaturated 15-membered D ring of madangamine A, and the (Z,Z)-unsaturated 11-membered E ring common to madangamines A-E, has been studied.

Direct, one-pot reductive alkylation of anilines with functionalized acetals mediated by triethylsilane and TFA. Straightforward route for unsymmetrically substituted ethylenediamine.

A new, robust, and reliable method has been developed for the selective reductive N-alkylation of primary and secondary aromatic amines with some functionalized acetals using TFA/Et(3)SiH as a reagent combination. A variety of unsymmetrically substituted ethylenediamines can be synthesized in a one-pot procedure in excellent yields at room temperature. This new procedure offers significant advantages over previous synthetic approaches, including brevity, mild reaction conditions, excellent yields, and high functional group tolerance.