[Analysis of occurrence of Chlamydophila pneumoniae infection serological markers in patients with bronchial asthma]. / Analiza wystepowania serologicznych markerów zakazenia Chlamydophila pneumoniae u chorych na astme oskrzelowa.

Numerous publications pointing the role of Chlamydophila pneumoniae infections in etiopathogenesis of bronchial asthma have appeared in recent years. Up to the presence the diagnostics of Chlamydophila pneumoniae infections has been based on the serological examinations especially on indirect microimmunofluorescence which is regarded to be a "gold standard". The aim of the paper was to compare the occurrence of Chlamydophila pneumoniae infection serological markers in the group of patients with asthma (N = 38) and in the control group (N = 38). The obtained results have allowed making the following conclusions: 1. The increased level of IgG class anti-Chlamydophila pneumoniae antibodies in the group of patients with asthma, which proves more frequent contact with Chlamydophila pneumoniae in that group, seems to support the hypothesis about the role of chlamydial infections in etiopathogenesis of bronchial asthma. 2. The single assessment of anti-Chlamydophila pneumoniae antibodies in the ELISA test has not allowed determining the type of chlamydial infection in unambiguous way. However, with reference to the entire clinical picture, the statement of the contact with Chlamydophila pneumoniae can be helpful especially in the treatment of severe asthma.

[Concentration of interleukin-6 and interleukin-12 in pregnant women infected and noninfected with parvovirus B19]. / Stezenia interleukin 6 oraz 12 u kobiet ciezarnych zakazonych ludzkim parwowirusem B19 i niezakazonych.

The aim of the study was to pay attention to the frequency and consequences of Parvovirus B19 infection and observation of IL-6 and IL-12 concentrations in pregnant women who have or have not undergone parvovirus infection. In 32 pregnant women in their first or the next pregnancy with the imminent abortion IgM and IgG antibodies against Parvovirus B19 and serum concentrations of IL-6 and IL-12 were determined using ELISA test. Parvovirus infection was diagnosed in 14 patients, abortion occurred in 5 cases and in 1 case fetal dystrophy was found. In the group of 18 noninfected pregnant women all the pregnancies were finished by healthy newborn delivery. Statistical analysis showed significant increase of IL-6 and IL-12 concentrations in patients infected by parvovirus in comparison to the noninfected group. The estimation of IL-6 concentration may be helpful in evaluation of existing intrauterine inflammation. The concentration of IL-12 should be analysed taking under consideration its role in the cytokine network.