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J Med Chem ; 60(24): 10220-10230, 2017 12 28.
Article in English | MEDLINE | ID: mdl-29202233

ABSTRACT

Novel hybrid molecule containing 2-mercaptoethylamine was synthesized starting from O-propyloxime-N-propoxy bacteriopurpurinimide (dipropoxy-BPI), which was readily oxidized in oxygen atmosphere yielding the corresponding disulfide analogue (disulfide-BPI). Spectral, photophysical, photodynamic, and biological properties of compound were properly evaluated. Compounds bearing disulfide moiety can directly interact with glutathione (GSH), thereby reducing its intracellular concentration. Indeed, mice sarcoma S37 cell line was treated in vitro with disulfide-BPI, yielding a CC50 value of 0.05 ± 0.005 µM. A relatively high level of singlet oxygen was detected. It was demonstrated (by fluorescence) that the PS was rapidly accumulated in a cancer nest (S37) at a relatively high level after 2 h upon intravenous administration. After 24 h, no traces of the molecule were detected in the tumor mass. Moreover, high photodynamic efficiency was demonstrated at doses of 150-300 J/cm2 against two different in vivo tumor models, achieving 100% regression of cancer growth.


Subject(s)
Photochemotherapy/methods , Photosensitizing Agents/chemistry , Photosensitizing Agents/pharmacology , Administration, Intravenous , Animals , Cell Line, Tumor , Chemistry Techniques, Synthetic , Disulfides/chemistry , Female , Glutathione/metabolism , Mice , Photosensitizing Agents/chemical synthesis , Photosensitizing Agents/pharmacokinetics , Porphyrins/chemistry , Rats , Sarcoma, Experimental/drug therapy , Singlet Oxygen/chemistry , Tissue Distribution
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