ABSTRACT
Purpose To report long-term results of the Argus T adjustable system for treatment of post-prostatectomy urinary incontinence (PPI). Materials and Methods From October 2007 to August 2008, 37 patients with PPI were included in a prospective, single-arm, multicenter trial of treatment with the Argus T adjustable system (Promedon, Argentina). Preoperative evaluation included urine culture, urethrocystoscopy, urodynamic testing, 24-h pad weight test (PWT) and quality of life questionnaires. Patients were stratified according to baseline degree of incontinence (mild–moderate or severe). Postoperative evaluation included immediate PWT, quality of life questionnaires and daily use of pads at 1, 12 and 30 months. Results and Conclusions One patient was lost to follow-up. At the 30-month follow-up, 24/31 patients (77%) were dry, 3/31 (10%) improved and 4/31 (13%) were failures. In particular, in the mild-moderate group, 8/8 (100%) patients were dry. In the severe group, 20/28 patients (71%) were dry, 3/28 (11%) improved and 5/28 (18%) were failures. Median visual analogue scale (VAS) scores dropped from 9 (4-10) to 0.5 (0-10) and International Consultation on Incontinence Questionnaire Short Form scores from (ICIQ-SF) 19 (12–21) to 1 (0–10). Retrograde leak point pressure increased from 18 (5–29) to 35 (22–45) cm H2O after intraoperative adjustment. Complications included immediate postoperative infection in 2/36 patients (6%) and transient inguinal and/or perineal pain in 22/36 patients (61%). Argus T has a long-term high success rate (86% cure + improvement at the 30-month follow-up). Good outcomes were achieved even in severe incontinence cases and maintained for over 30 months. .
Subject(s)
Aged , Aged, 80 and over , Humans , Male , Middle Aged , Prostatectomy/adverse effects , Suburethral Slings , Urinary Incontinence, Stress/surgery , Follow-Up Studies , Prospective Studies , Prosthesis Design , Quality of Life , Reproducibility of Results , Severity of Illness Index , Surveys and Questionnaires , Time Factors , Treatment Outcome , Urodynamics , Urinary Incontinence, Stress/etiologyABSTRACT
PURPOSE: To report long-term results of the Argus T adjustable system for treatment of post-prostatectomy urinary incontinence (PPI). MATERIALS AND METHODS: From October 2007 to August 2008, 37 patients with PPI were included in a prospective, single-arm, multicenter trial of treatment with the Argus T adjustable system (Promedon, Argentina). Preoperative evaluation included urine culture, urethrocystoscopy, urodynamic testing, 24-h pad weight test (PWT) and quality of life questionnaires. Patients were stratified according to baseline degree of incontinence (mild-moderate or severe). Postoperative evaluation included immediate PWT, quality of life questionnaires and daily use of pads at 1, 12 and 30 months. RESULTS AND CONCLUSIONS: One patient was lost to follow-up. At the 30-month follow-up, 24/31 patients (77%) were dry, 3/31 (10%) improved and 4/31 (13%) were failures. In particular, in the mild-moderate group, 8/8 (100%) patients were dry. In the severe group, 20/28 patients (71%) were dry, 3/28 (11%) improved and 5/28 (18%) were failures. Median visual analogue scale (VAS) scores dropped from 9 (4-10) to 0.5 (0-10) and International Consultation on Incontinence Questionnaire Short Form scores from (ICIQ-SF) 19 (12-21) to 1 (0-10). Retrograde leak point pressure increased from 18 (5-29) to 35 (22-45) cm H2O after intraoperative adjustment. Complications included immediate postoperative infection in 2/36 patients (6%) and transient inguinal and/or perineal pain in 22/36 patients (61%). Argus T has a long-term high success rate (86% cure + improvement at the 30-month follow-up). Good outcomes were achieved even in severe incontinence cases and maintained for over 30 months.
Subject(s)
Prostatectomy/adverse effects , Suburethral Slings , Urinary Incontinence, Stress/surgery , Aged , Aged, 80 and over , Follow-Up Studies , Humans , Male , Middle Aged , Prospective Studies , Prosthesis Design , Quality of Life , Reproducibility of Results , Severity of Illness Index , Surveys and Questionnaires , Time Factors , Treatment Outcome , Urinary Incontinence, Stress/etiology , UrodynamicsABSTRACT
UNLABELLED: Erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) are often associated, and they both reduce the quality of life of those who suffer from these conditions. OBJECTIVES: Primarily, to determine the relationship of LUTS/BPH as an independent risk factor for suffering ED and, secondarily, the relationship of LUTS/BPH and ED according to the severity of the symptoms. METHODS: A descriptive, analytic, multicentre study was carried out in 580 patients consulting for prostatic control or LUTS. 305 patients, who met the inclusion/exclusion criteria, were included in the analysis. Erectile dysfunction and LUTS were assessed by IIEF5 and IPSS. The presence, predictors and degree of severity of ED were examined according to patients' age and comorbidities. Qualitative and continuous variables were considered for the statistical analysis and simple and multiple regression analyses were applied. A value of p < 0.05 was considered statistically significant. RESULTS: Mean age was 62 years (IQR 56-67) ED prevalence in patients with LUTS/BPH was 83.6%. Patients with ED were older, showed a higher prevalence of hypertension and higher IPSS scores (p < 0.05). Multivariate analysis for ED predictors showed that age, diabetes and IPSS score were significantly associated with ED (p < 0.05). CONCLUSIONS. According to our results, there is a high prevalence of ED in patients with LUTS/BPH, which are also independent risk factors for suffering ED. The presence of ED was more prevalent in moderate LUTS/BPH than in the severe LUTS/BPH. The importance of assessing the sexual health of men consulting for LUTS/BPH is emphasized.
Subject(s)
Erectile Dysfunction , Quality of Life , Argentina , Humans , Lower Urinary Tract Symptoms , Prostatic Hyperplasia , Referral and ConsultationABSTRACT
OBJECTIVE: To communicate long-term results of the multicentre phase III trial post-prostatectomy urinary incontinence (PPI) treated with an adjustable male sling. PATIENTS AND METHODS: 48 PPI patients were included in this trial from April 2003 to September 2004. 39 post radical prostatectomy and 9 post adenomectomy. 19 wore 5 pads per day (3-8) each weight 83 gr (17-198). 29 wore condom catheter or penile clamp The Argus was implanted through perineal approach. Using needles, the sling was transferred to the abdominal wall where it was adjusted by washers. The adjustment was done with retrograde urethral pressure from 45 to 55 cm water. Clinical data were updated till September 2007. The mean follow-up was 45 months (36-54) and median age was 67 years (52-77). The evaluation was: the ICIQ-SF score and qualification as Dry: no pads, Improved: 1 pad and Failed: 2 or more pads in 24 hr, including those with slings removed. RESULTS: 47 were evaluated, resulting: 31 (66%) Dry, 6 (12.8%) Improved and 10 (21%) Failed. The ICIQ-SF score changed from 19.5 to 6. Of the 31 dry pts, 5 required one adjustment. 10 pts failed, 9 after sling removal, 6 due to erosion and 3 for infection. One patient failed with the sling in place, 6 erosions were registered: 4 in the urethra, 1 into the bladder and 1 through the abdominal wall. Perineal pain persisted in 2. One patient was excluded, died in September 2006. CONCLUSIONS: Argus has demonstrated its efficacy in long- term follow-up. The social continence rate was about 80%. The important complication was erosion or infection.
Subject(s)
Prostatectomy/adverse effects , Suburethral Slings , Urinary Incontinence/etiology , Urinary Incontinence/surgery , Aged , Equipment Design , Humans , Male , Middle Aged , Prosthesis Design , Time Factors , Urologic Surgical Procedures, Male/methodsABSTRACT
INTRODUCTION: The high incidence of erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) in aging men and the same pathophysiology make probable to treat both disorders with the same treatment. Numerous authors evaluated the actions of PDE5i in improving the LUTS/(benign prostate hyperplasia) BPH. AIM: To assess the efficacy and safety of tamsulosin 0.4 mg/day vs. tamsulosin 0.4 mg/day plus tadalafil 20 mg/day in patients with LUTS in a crossover design study. MAIN OUTCOMES MEASURES: International Prostate Symptoms Score (IPSS), IPSS Quality of Life (IPSS-QOL), maximum flow rate (Qmax), post-void residual volume (PVR), International Index of Erectile Function-Erectile Function Domain (IIEF-EF), Global Assessment Quality (GAQ). For the statistical analysis, a Tukey-Kramer multicomparison test was used. METHODS: A randomized, double-blind, crossover study was conducted from September 2007 to February 2008 in one center. Thirty men, older than 50 years old, with a history of LUTS/BPH of at least 6 months, were randomized into two groups to receive tamsulosin 0.4 mg/day vs. tamsulosin 0.4 mg/day plus tadalafil 20 mg/day for 45 days, and then switched to the other treatment mode for other 45 days. RESULTS: Twenty-seven patients completed the study. Improvements of IPSS score and IPSS-QOL were significant with both treatments but greater with the drug combination. Both regimens similarly improved the Qmax and decreased the PVR volume from baseline (P < 0.001) with no significant differences between tamsulosin alone vs. tamsulosin and tadalafil (P > 0.05). The IIEF improved with tamsulosin plus tadalafil (P < 0.001) but not with tamsulosin alone (P > 0.05). The GAQ showed that all patients preferred the combination scheme. Both treatments were well tolerated. CONCLUSION; Tamsulosin 0.4 mg/day plus tadalafil 20 mg/day was more effective than tamsulosin 0.4 mg/day alone to improve LUTS and erectile dysfunction and was also well tolerated. Large-scale, randomized, placebo-controlled studies are needed to further assess the long-term safety and effectiveness of these agents in treating LUTS/BPH with or without ED.
Subject(s)
Carbolines/administration & dosage , Erectile Dysfunction/drug therapy , Phosphodiesterase Inhibitors/administration & dosage , Prostatic Hyperplasia/drug therapy , Sulfonamides/administration & dosage , Urinary Bladder Neck Obstruction/drug therapy , Urinary Retention/drug therapy , Aged , Carbolines/adverse effects , Cross-Over Studies , Double-Blind Method , Drug Therapy, Combination , Humans , Male , Middle Aged , Phosphodiesterase 5 Inhibitors , Quality of Life , Sulfonamides/adverse effects , Tadalafil , Tamsulosin , Treatment OutcomeABSTRACT
Inter epididymal testicular torsion of the spermatic cord is extremely rare and usually diagnosed at surgery. We present an unusual case of spermatic cord torsion in a 14-year-old male patient. It is important to highlight that the torsion occurred only on the distal half of the epididymis leaving the head untwisted and edematous. In addition, the fact that this condition was painless made this case extremely rare and motivated our presentation.
Subject(s)
Epididymis , Spermatic Cord Torsion/diagnostic imaging , Adolescent , Humans , Male , Orchiectomy , Spermatic Cord Torsion/complications , Spermatic Cord Torsion/surgery , Ultrasonography, Doppler, ColorABSTRACT
Inter epididymal testicular torsion of the spermatic cord is extremely rare and usually diagnosed at surgery. We present an unusual case of spermatic cord torsion in a 14-year-old male patient. It is important to highlight that the torsion occurred only on the distal half of the epididymis leaving the head untwisted and edematous. In addition, the fact that this condition was painless made this case extremely rare and motivated our presentation.
Subject(s)
Humans , Male , Adolescent , Epididymis , Pain/etiology , Spermatic Cord Torsion , Orchiectomy , Spermatic Cord Torsion/complications , Spermatic Cord Torsion/surgery , Ultrasonography, Doppler, ColorABSTRACT
Objetivos: Mostrar luego de 13 años de experiencia contínua, los resultados en lo que a continencia y micción se refiere de la neovejiga colónica derecha, como así también los fundamentos fisiológicos y urodinámicos de los mismos. Materiales y Métodos: Entre febrero de 1993 y marzo de 2006 a 43 pacientes cistectomizados, por presentar cáncer de vejiga, se les reconstruyo el tracto urinario inferior utilizando un reservorio construido con colon derecho destubulizado y reconfigurado y ciego intacto. A todos los pacientes se les realizo cistografías al retirar el catéter uretral, a 32 estudios urodinámicos y a 5 videourodinámicos. Resultados: Cuarenta y un pacientes (95,4 porciento) orinan con un flujo máximo de más de 25 ml/seg. La continencia diurna y nocturna fue completa e inmediata en el 97 porciento y 93 porciento respectivamente, un paciente requiere cateterismo intermitente, otro permanece incontinente y los dos restantes lograron continencia nocturna satisfactoria. Se define como continencia completa e inmediata al control de la orina sin necesidad de usar paño protector desde el momento en que se retira el catéter uretral, satisfactoria al uso de no mas de un pañal por día y micción espontánea y efectiva a la evacuación del reservorio con un flujo medio de 10 ml/seg. sin residuo postmiccional. Conclusión: Los resultados con esta nueva neovejiga colónica derecha, en lo que a continencia y micción se refiere, son significativamente superiores a los logrados con otros procedimientos descriptos en la literatura
Subject(s)
Urinary Bladder NeoplasmsABSTRACT
Objetivos: Mostrar luego de 13 años de experiencia contínua, los resultados en lo que a continencia y micción se refiere de la neovejiga colónica derecha, como así también los fundamentos fisiológicos y urodinámicos de los mismos. Materiales y Métodos: Entre febrero de 1993 y marzo de 2006 a 43 pacientes cistectomizados, por presentar cáncer de vejiga, se les reconstruyo el tracto urinario inferior utilizando un reservorio construido con colon derecho destubulizado y reconfigurado y ciego intacto. A todos los pacientes se les realizo cistografías al retirar el catéter uretral, a 32 estudios urodinámicos y a 5 videourodinámicos. Resultados: Cuarenta y un pacientes (95,4 porciento) orinan con un flujo máximo de más de 25 ml/seg. La continencia diurna y nocturna fue completa e inmediata en el 97 porciento y 93 porciento respectivamente, un paciente requiere cateterismo intermitente, otro permanece incontinente y los dos restantes lograron continencia nocturna satisfactoria. Se define como continencia completa e inmediata al control de la orina sin necesidad de usar paño protector desde el momento en que se retira el catéter uretral, satisfactoria al uso de no mas de un pañal por día y micción espontánea y efectiva a la evacuación del reservorio con un flujo medio de 10 ml/seg. sin residuo postmiccional. Conclusión: Los resultados con esta nueva neovejiga colónica derecha, en lo que a continencia y micción se refiere, son significativamente superiores a los logrados con otros procedimientos descriptos en la literatura(AU)
Subject(s)
Urinary Bladder NeoplasmsABSTRACT
OBJECTIVE: To evaluate the efficacy and safety of a new adjustable bulbourethral sling (Argus, Promedon SA, Cordoba, Argentina) in the treatment of male stress urinary incontinence (SUI) after prostate surgery. PATIENTS AND METHODS: In all, 48 patients with SUI because of prostatic surgery for prostate cancer (39) or benign prostatic hyperplasia (nine) had a new sling implanted in a multicentre trial at six institutions between April 2003 and September 2004. All patients were fully evaluated, including a questionnaire (International Consultation on Incontinence Questionnaire-Short Form, ICIQ-SF, range 0-21), endoscopy, and urodynamic evaluation. The Argus system comprises a 4.2 x 2.6 x 0.9 cm thick silicone foam pad for soft bulbar urethral compression. The pad is attached to the silicone cone columns that, after being passed with needles from the perineum to the abdominal wall, are adjusted with silicone washers to regulate and keep the desired tension against the urethra. The pad and washers are radio-opaque, which allows their position to be assessed during follow-up. The surgical technique was one described previously, with some modifications. RESULTS: At a mean (range) follow-up of 7.5 (1-17.5) months, 35 (73%) of the 48 patients were dry, five (10%) were improved, and eight (17%) were incontinent, including four (8%) who needed sling adjustment. The mean (range) ICIQ-SF improved from 19.2 (12-21) to 4 (0-21). There were three (6%) urethral perforations during surgery that were resolved by re-passing the needle. The sling was removed in three men (6%) due to erosion and in two (4%) due to infection. Seven (15%) cases of acute urinary retention resolved spontaneously, except for one that needed the sling loosening. No cases of chronic retention were reported. There was perineal discomfort and mild dysuria soon after surgery that resolved spontaneously after a few weeks. CONCLUSION: This new adjustable male sling safely and effectively controls sphincter incontinence in men after prostate surgery, with an acceptably low complication rate. The early results are encouraging; the Argus is a valid alternative to the artificial urinary sphincter, the standard therapy for this condition.
Subject(s)
Prostatectomy/adverse effects , Prostatic Neoplasms/surgery , Surgical Mesh , Urinary Incontinence, Stress/surgery , Aged , Follow-Up Studies , Humans , Male , Middle Aged , Silicones , Treatment Outcome , Urinary Incontinence, Stress/etiology , Urinary Sphincter, Artificial , Urodynamics , Urologic Surgical Procedures/methodsABSTRACT
PURPOSE: We report the long-term functional results of the colonic neobladder and provide the physiological and urodynamic foundations for them. MATERIALS AND METHODS: From March 1993 to February 2004, 38 patients with cystectomy received a neobladder constructed from detubularized, remodeled right colon and intact cecum following our design at the urology service at our institution. Most patients underwent urodynamics and videourodynamics as postoperative followup. We defined total continence as not using any protection whatsoever (neither pads nor a night alarm), which was immediate upon removing the urethral catheter. RESULTS: A total of 37 patients achieved total daytime continence immediately and the remaining 1 was totally continent after 30 days (100%). Nighttime continence was total and immediate in 36 patients (92%) and satisfactory in 2. Micturition was immediate, satisfactory and total in 37 patients with an average maximum flow of more than 26 ml per second. The patient who did not achieve micturition required clean intermittent catheterization. Videourodynamic studies revealed that continence resulted from the low pressure developed in the large capacity reservoir (more than 600 ml) and from intact intestine haustral contractions, which ejected urine toward the detubularized and remodeled area. In turn, micturition was attained through a combination of abdominal wall tension and mass contractions of the nondetubularized segment, which generated a pressure of more than 100 cm. CONCLUSIONS: The functional results of this new neobladder are significantly greater than those achieved with other procedures already described in the literature because of the different way in which it functions.