ABSTRACT
The authors have studied mexicor's efficacy in a comprehensive treatment of 25 patients suffering from atherosclerosis obliterans of the lower extremities with grade II-III ischaemia. The state of the vascular bed and the degree of arteries' narrowing were assessed by means of colour duplex scanning of the lower limb arteries using the unit Vivid 7 manufactured by the Company <
Subject(s)
Arteriosclerosis Obliterans/drug therapy , Leg/blood supply , Pyridines/administration & dosage , Angiography , Arteriosclerosis Obliterans/diagnostic imaging , Follow-Up Studies , Humans , Infusions, Intravenous , Male , Middle Aged , Plethysmography, Impedance , Treatment Outcome , Ultrasonography, Doppler, DuplexABSTRACT
The method of cell-associated antibiotic therapy consists of extracorporal exposure of the autoblood formed elements to antibiotic solution followed by their reinfusion. Pharmacokinetics of erythromycin after its intravenous and cell-associated administration in patients with community-acquired pneumonia and the clinical efficacy of the method were evaluated. HPLC of the erythromycin pharmacokinetic pattern in 20 patients showed that after the antibiotic target transport the pharmacokinetic model changed from one-compartment to two-compartment one and the antibiotic maximum concentration and elimination rate were lower vs. the intravenous administration. It was also shown that the clinical efficacies of the erythromycin intravenous administration and target transport did not significantly differ, whereas after the cell-associated transport of the antibiotic the therapeutic effect was observed earlier and the side effects were less frequent.
Subject(s)
Anti-Bacterial Agents/pharmacokinetics , Blood Transfusion, Autologous , Erythromycin/pharmacokinetics , Pneumonia/metabolism , Adult , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/metabolism , Blood Cells/metabolism , Drug Delivery Systems/methods , Erythromycin/administration & dosage , Erythromycin/metabolism , Female , Humans , Infusions, Intravenous , Male , Pneumonia/drug therapyABSTRACT
Under study were catalase activity and indicators of lipid peroxidation (LP) of donor blood exposed to different doses of UV irradiation. Doses lower than 630 J/m2 were found to activate catalase and to inhibit LP while doses higher than 630 J/m2 inhibited catalase activity and activated LP. The indicators of LP have confirmed that therapeutic doses of UV-irradiated blood were nontoxic. The most optimal therapeutic dose of irradiation (630 J/m2) was determined.
Subject(s)
Blood Donors , Catalase/radiation effects , Lipid Peroxidation/radiation effects , Ultraviolet Rays , Adult , Blood/radiation effects , Blood Transfusion, Autologous , Catalase/blood , Dose-Response Relationship, Radiation , Humans , Lipids/blood , Lipids/radiation effects , Ultraviolet TherapyABSTRACT
The results of complex treatment of 81 patients with pyoinflammatory diseases with the use of blood ultraviolet irradiation are discussed. A marked clinical effect was noted, the terms of treatment reduced by 5-10 days, the outcomes improved, and the number of complications decreased. Irradiation of autologous blood by ultraviolet rays led to modulation of the indices of antimicrobial protection, increase of the intensity of the histochemical reaction to peroxidase up to 40-50%, and diminution of pH in the neutrophil phagosomes to 5.0. The ultrastructure and ability of thrombocytes to store serotonin were restored, and intensity of their metabolic processes increased, the membrane phospholipid composition changed, and juvenile platelet forms appeared.