Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Vopr Virusol ; 48(4): 16-20, 2003.
Article in Russian | MEDLINE | ID: mdl-12945201

ABSTRACT

The recombinant strain of Salmonella typhimurium SL7207/pBMC-env, carrying a plasmid containing the gene of protein HIV-1 gp-160, was obtained under the monitoring by CMV-promoter. The above strain was used in the rectal and oral immunization of BALB/c mice. HIV-specific antibodies were detected in serum after a one-time immunization; such antibodies were able to inhibit the viral replication in vitro. Furthermore, the shaping-up of the specific cytotoxic and of proliferative responses was registered. Finally, the rectal immunization by cells of the Salmonella recombinant strain can be regarded as a promising delivery system of DNA-vaccine (pBMC-env), and it is more effective versus the oral immunization variant.


Subject(s)
AIDS Vaccines/immunology , HIV Envelope Protein gp120/immunology , HIV Infections/immunology , HIV-1 , Vaccines, DNA/immunology , AIDS Vaccines/administration & dosage , AIDS Vaccines/genetics , Administration, Oral , Administration, Rectal , Animals , Cytotoxicity Tests, Immunologic , Genetic Vectors/administration & dosage , HIV Antibodies/blood , HIV Envelope Protein gp120/genetics , HIV Infections/blood , Immunoenzyme Techniques , Lymphocyte Activation , Mice , Mice, Inbred BALB C , Salmonella typhimurium/genetics , Vaccines, DNA/administration & dosage , Vaccines, DNA/genetics
SELECTION OF CITATIONS
SEARCH DETAIL
...