Q-band electron paramagnetic resonance dosimetry in tooth enamel: biopsy procedure and determination of dose detection limit.

High-frequency Q-band (37 GHz) electron paramagnetic resonance (EPR) dosimetry allows to perform fast (i.e., measurement time <15 min) dose measurements using samples obtained from tooth enamel mini-biopsy procedures. We developed and tested a new procedure for taking tooth enamel biopsy for such dose measurements. Recent experience with EPR dose measurements in Q-band using mini-probes of tooth enamel has demonstrated that a small amount of tooth enamel (2-10 mg) can be quickly obtained from victims of a radiation accident. Accurate dose assessments can further be carried out in a very short time to provide important information for medical treatment. Here, the Q-band EPR dose detection limit for 5 and 10 mg samples is estimated to be 367 and 248 mGy, respectively. These values are comparable to the critical parameters determined for conventional X-band EPR in tooth enamel.

Fingernail dosimetry: current status and perspectives.

A summary of recent developments in fingernail EPR dosimetry is presented in this paper. Until 2007, there had been a very limited number of studies of radiation-induced signals in fingernails. Although these studies showed some promising results, they were not complete with regard to the nature of non-radiation signals and the variability of dose dependence in fingernails. Recent study has shown that the two non-radiation components of the EPR spectrum of fingernails are originated from mechanical stress induced in the samples at their cut. The mechanical properties of fingernails were found to be very similar to those of a sponge; therefore, an effective way to eliminate their mechanical deformation is by soaking them in water. Stress caused by deformation can also significantly modify the dose response and radiation sensitivity. Consequently, it is critically important to take into account the mechanical stress in fingernail samples under EPR dose measurements. Obtained results have allowed formulating a prototype of a protocol for dose measurements in human fingernails.

Effect of background radiation on the lower limit of detection for extended dosemeter issue periods.

An extension of dosemeter issue period brings significant economic and logistic benefits. Therefore, it is desirable to have an extended period as long as possible without significant loss of the quality of dose measurements. There are many studies devoted to the investigation of fading or reduction of the dose accumulated in dosemeters with time. However, this is one of many critical factors that need's to be taken into account when extending the dosemeter issue period. Background radiation is also a critical factor that needs to be appropriately accounted. In this report, a new approach has been suggested for evaluating the effect of background radiation on the lower limit of detection (LLD) of occupational radiation dose. This approach is based on the data collected from control dosemeters that are routinely used for subtraction of background radiation from occupational dose measurements. The results show that for LiF:Mg,Cu,P thermoluminescence dosemeters, variations in background radiation have a higher impact on the LLD than dose fading and the absolute value of background radiation. Although there is no significant dose fading in LiF:Mg,Cu,P for a dosemeter issue period up to 1 y, variations in background radiation during this period of time can significantly increase photon LLDs (up to 700 microSv) for workers operating in an environment of variable radiation background.

Monte Carlo-based calculation of imaging plate response to (90)Sr in teeth: experimental validation of the required correction on sample thickness.

Recently, a numerical method was proposed to correct the imaging plate (IP) response to (90)Sr concentration in tooth samples, depending on the sample thickness. This is important to quantify any (90)Sr concentration in teeth, which in turn is necessary to determine any (90)Sr incorporation of a person retrospectively. Although the final goal will be to evaluate the (inhomogeneous) spatial distribution of (90)Sr inside tooth samples precisely, the present study was restricted -- as a first step -- to the evaluation of (90)Sr in teeth assuming a uniform (90)Sr distribution. A numerical method proposed earlier was validated experimentally in the present study by measuring the IP response to standard sources of various thicknesses and (90)Sr concentrations. For comparison, the energy deposition of the beta-rays emitted by (90)Sr in the IP -- which is considered to be proportional to the IP luminescence signal -- was calculated for the various sample thicknesses involved, by means of the MCNP-4C code. As a result, the measured IP response could be reproduced by the calculations within the uncertainties, depending on the thickness of the standard sources. Thus, the validity of the proposed numerical method to correct the IP response for sample thickness has successfully been demonstrated.

In Vivo EPR For Dosimetry.

As a result of terrorism, accident, or war, populations potentially can be exposed to doses of ionizing radiation that could cause direct clinical effects within days or weeks. There is a critical need to determine the magnitude of the exposure to individuals so that those with significant risk have appropriate procedures initiated immediately, while those without a significant probability of acute effects can be reassured and removed from the need for further consideration in the medical/emergency system. In many of the plausible scenarios there is an urgent need to make the determination very soon after the event and while the subject is still present. In vivo EPR measurements of radiation-induced changes in the enamel of teeth is a method, perhaps the only such method, which can differentiate among doses sufficiently for classifying individuals into categories for treatment with sufficient accuracy to facilitate decisions on medical treatment. In its current state, the in vivo EPR dosimeter can provide estimates of absorbed dose with an error approximately +/- 50 cGy over the range of interest for acute biological effects of radiation, assuming repeated measurements of the tooth in the mouth of the subject. The time required for acquisition, the lower limit, and the precision are expected to improve, with improvements in the resonator and the algorithm for acquiring and calculating the dose. The magnet system that is currently used, while potentially deployable, is somewhat large and heavy, requiring that it be mounted on a small truck or trailer. Several smaller magnets, including an intraoral magnet are under development, which would extend the ease of use of this technique.

In vivo EPR dosimetry to quantify exposures to clinically significant doses of ionising radiation.

As a result of terrorism, accident or war, populations potentially can be exposed to doses of ionising radiation that could cause direct clinical effects within days or weeks. There is a critical need to determine the magnitude of the exposure to individuals so that those with significant risk can have appropriate procedures initiated immediately, while those without a significant probability of acute effects can be reassured and removed from the need for further consideration in the medical/emergency system. It is extremely unlikely that adequate dosemeters will be worn by the potential victims, and it also will be unlikely that prompt and accurate dose reconstruction at the level of individuals will be possible. Therefore, there is a critical need for a method to measure the dose from radiation-induced effects that occur within the individual. In vivo EPR measurements of radiation-induced changes in the enamel of teeth is a method, perhaps the only such method, which can differentiate among doses sufficiently to classify individuals into categories for treatment with sufficient accuracy to facilitate decisions on medical treatment. In its current state, the in vivo EPR dosemeter can provide estimates of absorbed dose of +/- 0.5 Gy in the range from 1 to >10 Gy. The lower limit and the precision are expected to improve, with improvements in the resonator and the algorithm for acquiring and calculating the dose. In its current state of development, the method is already sufficient for decision-making action for individuals with regard to acute effects from exposure to ionising radiation for most applications related to terrorism, accidents or nuclear warfare.

Analysis of current assessments and perspectives of ESR tooth dosimetry for radiation dose reconstruction of the population residing near the Semipalatinsk nuclear test site.

Between 1949 and 1989 the Semipalatinsk nuclear test site (SNTS), an area of 19,000 square km in northeastern Kazakhstan, was the location of over 400 nuclear test explosions with a total explosive energy of 6.6 Mt TNT (trinitrotoluene or trotyl) equivalent. It is estimated that the bulk of the radiation exposure to the population resulted from three tests, conducted in 1949, 1951, and 1953 although estimations of radiation doses received by the local population have varied significantly. Analysis of the published ESR dose reconstruction results for residents of the villages near the SNTS show that they do not correlate well with other methods of dose assessment (e.g. model dose calculation and thermo luminescence dosimetry (TLD) in bricks). The most significant difference in dose estimations was found for the population of Dolon, which was exposed as result of the first Soviet nuclear test in 1949. Published results of ESR measurements in tooth enamel are considerably lower than other dose estimations. Detailed analysis of these results is provided and a possible explanation for this discrepancy and ways to eliminate it are suggested.

Measurements of clinically significant doses of ionizing radiation using non-invasive in vivo EPR spectroscopy of teeth in situ.

There are plausible circumstances in which populations potentially have been exposed to doses of ionizing radiation that could cause direct clinical effects within days or weeks, but there is no clear knowledge as to the magnitude of the exposure to individuals. In vivo EPR is a method, perhaps the only such method that can differentiate among doses sufficiently to classify individuals into categories for treatment with sufficient accuracy to facilitate decisions on medical treatment. Individuals with significant risk then can have appropriate procedures initiated immediately, while those without a significant probability of acute effects could be reassured and removed from the need for further medical treatment. In its current state, the in vivo EPR dosimeter can provide estimates of absorbed dose of +/-25 cGy in the range of 100-->1000 cGy. This is expected to improve, with improvements in the resonator, the algorithm for calculating dose, and the uniformity of the magnetic field. In its current state of development, it probably is sufficient for most applications related to terrorism or nuclear warfare, for decision-making for action for individuals in regard to acute effects from exposure to ionizing radiation.