ABSTRACT
Hemolytic ocular film (HOF) represents a polymer-based "puff pastry" whose external layers contain antioxidant emoxipine and the internal layer contains an immobilized thrombolytic enzyme; such a structure ensures a successive multifunctional effect on the main components of pathogenesis: lipid peroxidation, local hemostasis, fibrinolysis, and immune system of patients with vascular abnormalities of the eyes. The drug was used in the treatment of 248 patients with intraocular hemorrhages of traumatic origin. Control group (150 patients with the same condition) was treated traditionally. Application of HOF resulted in complete or almost complete lysis of the blood in 95% of patients; in 5% the effect was null. Traditional therapy helped attain complete lysis of the blood in 9% and partial in 43% of patient; in 48% of patients the effect was null.
Subject(s)
Antioxidants/therapeutic use , Eye Hemorrhage/drug therapy , Fibrinolytic Agents/therapeutic use , Picolines/therapeutic use , Streptokinase/therapeutic use , Thrombolytic Therapy/methods , Acrylates , Antioxidants/administration & dosage , Drug Evaluation , Drug Therapy, Combination , Eye Hemorrhage/blood , Eye Hemorrhage/etiology , Eye Injuries/complications , Fibrinolysis/drug effects , Fibrinolytic Agents/administration & dosage , Follow-Up Studies , Humans , Picolines/administration & dosage , Streptokinase/administration & dosageABSTRACT
Streptodecase was used in experiments and in clinical practice for treatment of intraocular traumatic hemorrhages. The enzyme, at a dose of 30,000-45,000 .un, did not exhibit any toxico-allergic effects on eye tissues and caused maximal lysis of the blood clot. 114 patients were treated with the enzymatic preparation and in 60% of the patients blood, liberated into vitreous body, was completely lysed.
Subject(s)
Enzymes, Immobilized/therapeutic use , Eye Diseases/drug therapy , Eye Injuries/complications , Hemorrhage/drug therapy , Streptokinase/therapeutic use , Animals , Enzymes, Immobilized/administration & dosage , Eye Diseases/etiology , Hemorrhage/etiology , Humans , Hyphema/drug therapy , Hyphema/etiology , Rabbits , Streptokinase/administration & dosage , Vitreous BodySubject(s)
Enzymes, Immobilized/therapeutic use , Eye Injuries/drug therapy , Hemorrhage/drug therapy , Hyphema/drug therapy , Streptokinase/therapeutic use , Chronic Disease , Delayed-Action Preparations , Drug Evaluation , Female , Humans , Length of Stay , Male , Postoperative Complications/drug therapy , Time FactorsSubject(s)
Hemorrhage/surgery , Vitrectomy/methods , Vitreous Body/surgery , Animals , Eye Diseases/surgery , Humans , Rabbits , Vitreous Body/injuriesSubject(s)
Electroretinography/methods , Eye Injuries/complications , Hemorrhage/diagnosis , Retina/physiopathology , Vitreous Body , Adult , Animals , Color , Hemorrhage/etiology , Humans , Male , Rabbits , Time FactorsSubject(s)
Eye Diseases/pathology , Hemorrhage/pathology , Animals , Eye/pathology , Eye Diseases/etiology , Fibrin/physiology , Hemorrhage/etiology , Rabbits , Time FactorsSubject(s)
Retinal Vein , Streptokinase/administration & dosage , Thrombosis/drug therapy , Adolescent , Adult , Aged , Female , Humans , Male , Middle AgedSubject(s)
Eye Injuries/diagnosis , Hemorrhage/diagnosis , Ultrasonography , Adolescent , Adult , Animals , Female , Humans , Male , Middle Aged , Rabbits , Time Factors , Vitreous Body/injuriesABSTRACT
Lipid peroxidation (LPO) in eye tissues of rabbits with experimental herpetic keratitis was evaluated from the malonic dialdehyde content and chemiluminescence intensity. It appeared that during the critical phase LPO sharply increased in all the tissues under study and in anterior chamber humor. After administration of the synthetic water-soluble antioxidant, hydroxypyridine-6 the subconjunctival content of malonic dialdehyde and chemiluminescence intensity approached normal values accompanied by positive therapeutic effect.
