ABSTRACT
INTRODUCTION: A few models for pneumonectomy in rats have been described, and in most of these, anesthesia includes orotracheal intubation, which increases morbidity and mortality and also adds technical complexity. Models without tracheal intubation but with injectable anesthesia are difficult to reproduce, however, and lead to a lengthy postoperative-recovery period with high morbidity and mortality rates. OBJECTIVE: The objective of this study was to describe a simple, safe, and effective experimental model for pneumonectomy in rats without tracheal intubation. MATERIALS AND METHODS: A left-sided pneumonectomy was performed on 26 Sprague-Dawley rats anesthetized by isoflurane applied via a mask without tracheal intubation. To avoid dangerous traction movements, the lung pedicle was ligated en bloc using clips. RESULTS AND DISCUSSION: No rat demonstrated cardiorespiratory depression. Of the 26 rats, 1 was dehydrated and had lost more than 10% of its body weight, resulting in death on the third day after surgery. Total mortality was therefore 3.8%. Mean (standard deviation [SD]) anesthesia duration was 9.8 (1.0) minutes, surgery time was 3.0 (0.6) minutes, and open pneumothorax time was 1.2 (0.3) minutes. Mean (SD) weight loss during the early postoperative period was 4.5% (3.5%). These results were more satisfactory than results obtained using ketamine mixtures as anesthetic agents (ketamine plus xylacine, and ketamine plus diazepam). CONCLUSION: Our model for left-sided pneumonectomy in isoflurane-anesthetized rats does not require endotracheal intubation and is effective, safe, quick, and easily reproducible.
Subject(s)
Anesthesia Recovery Period , Anesthesia, Inhalation/methods , Intubation, Intratracheal , Isoflurane/administration & dosage , Pneumonectomy/methods , Anesthetics, Inhalation/administration & dosage , Animals , Contraindications , Disease Models, Animal , Rats , Rats, Sprague-Dawley , Reproducibility of ResultsABSTRACT
La localización del plasmocitoma a nivel esternales excepcional. Se presenta el caso de un pacientecon una tumoración en la región del manubrio esternal,sin diagnóstico de certeza a pesar de la PAAF yde la biopsia incisional efectuadas. Se realizó unaresección con amplios márgenes de la lesión, reconstruyendoel defecto con una malla de polipropileno.Los resultados postoperatorios fueron satisfactorios.Se efectúa una revisión de la literatura
The localization of plasmacytoma in the sternumis exceptional. A patient suspected of having a sternalmanubrium tumor, without a clear diagnosisdespite a fine needle aspiration biopsy and an incisionbiopsy is presented. A wide margin resectionof the lesion and reconstruction with a polypropylenemesh were undertaken. The results were satisfactory.A review of the literature is made
