ABSTRACT
The diffusing capacity of the lung (DL) or transfer factor for the lung (T1) for carbon monoxide (DLCO) was determined, at rest, by single-breath method in 65 normal subjects ranging in age from 60 to 84 years. The subjects were divided into four groups: 15 male smokers (MS); 20 male non-smokers (MNS); 10 female smokers (FS); 20 female non-smokers (FNS). The DLCO was determined using the "Collins Computerized Modular Lung Analyser". The inspired mixture consisted of 0.3 per cent carbon monoxide, 10.0 per cent helium, 21.0 per cent oxygen and 68.7 per cent nitrogen. The mean values and the standard derivations for DLCO (ml/min/mmHg) were: 23.31 +/- 6.48 in MS; 29.33 +/- 6.27 in MNS; 19.74 +/- 5.87 in FS; 19.55 +/- 4.86 in FNS. The DLCO was found to be dependent upon age and body surface area (BSA). Regression equations for predicting normal DLCO have been determined for every one of the four groups (MS, MNS, FS, FNE). Difference, statistically significant was found for MS as compared to MNS, FS and FNS. Therefore two regression equations for predicting normal DLCO have been determined; one for male smokers (MS) and other for male non-smokers (MNS), female smokers (FS) and female non-smokers (FNS). The regression equation for predicting normal DLCO for male smokers (MS) was: DLCO (ML/min/mmHg) = 9.37 - 0.22 Age (Years) + 19.99 BSA (M2). The regression equation for predicting normal DLCO for male non-smokers (MNS), female smokers (FS) and female non-smokers (FNS) was: DLCO (ml/min/mmHg) = 25.05 - 0.27 Age (Years) + 8.41 BSA (m2).(ABSTRACT TRUNCATED AT 250 WORDS)
Subject(s)
Pulmonary Diffusing Capacity/physiology , Smoking/physiopathology , Age Factors , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Reference Values , Regression Analysis , Sex FactorsSubject(s)
L-Lactate Dehydrogenase/analysis , Pleural Effusion/enzymology , Aged , Aged, 80 and over , Empyema/complications , Heart Failure/complications , Humans , Isoenzymes , Lung Neoplasms/complications , Middle Aged , Myocardial Revascularization/adverse effects , Pleural Effusion/etiology , Tuberculosis/complicationsSubject(s)
Lung/abnormalities , Adolescent , Adult , Child , Diagnosis, Differential , Female , Humans , Male , Middle Aged , Retrospective Studies , Tuberculosis, Pulmonary/diagnosisSubject(s)
Hospitals, General , Lung Diseases , Medicine , Specialization , Brazil , Education, Medical/trends , Internal Medicine/educationSubject(s)
Bronchial Diseases/physiopathology , Lung Diseases, Obstructive/physiopathology , Pulmonary Ventilation , Adolescent , Adult , Aged , Aged, 80 and over , Female , Forced Expiratory Flow Rates , Forced Expiratory Volume , Humans , Male , Maximal Voluntary Ventilation , Middle Aged , Reference ValuesSubject(s)
Blood Protein Electrophoresis , Carcinoma, Bronchogenic/blood , Lung Neoplasms/blood , Tuberculosis, Pulmonary/blood , Carcinoma, Bronchogenic/diagnosis , Diagnosis, Differential , Humans , Lung Neoplasms/diagnosis , Retrospective Studies , Tuberculosis/diagnosis , Tuberculosis, Lymph Node/bloodSubject(s)
Biopsy, Needle/methods , Carcinoma, Bronchogenic/pathology , Lung Neoplasms/pathology , Adult , Aged , Female , Humans , Lung Diseases/pathology , Male , Middle AgedSubject(s)
Histoplasmosis/diagnosis , Lung Diseases, Fungal/diagnosis , Adult , Female , Histoplasmosis/diagnostic imaging , Histoplasmosis/drug therapy , Humans , Ketoconazole/therapeutic use , Lung/pathology , Lung Diseases, Fungal/diagnostic imaging , Lung Diseases, Fungal/drug therapy , Male , Middle Aged , RadiographySubject(s)
Carcinoma, Bronchogenic/epidemiology , Lung Neoplasms/epidemiology , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Retrospective Studies , Sex Factors , SmokingABSTRACT
A total of 245 patients submitted to lung function test were studied. They were divided in 2 groups: A--FEV1.0/FVC greater than or equal to 75% and B--FEF25-75% less than 75%. These groups were further subdivided according to the age of the patients--subgroup 1 less than or equal to 50 years and subgroup 2 greater than 50 years. Patients with restrictive disorders were not included. The spirometric equipment employed was Hewlett-Packard Inc. Pulmonary Function Analyzer 47402-A. The results were obtained through a digital system and calculated from a graph impressed in a xy register. Results were automatically corrected to BTPS. In each group FVC and FEV1.0 were normal. In group A FVC and FEV1.0 were, respectively: A1-99.63 +/- 13.33 and 101.11 +/- 12.24, A2-97.60 +/- 11.06 and 98.81 +/- 12.18, expressed as percentage of predicted values. In group B the results were: B1-97.61 +/- 13.55% and 81.71 +/- 14.44%; B2-100.28 +/- 13.98% and 83.10 +/- 16.42%. The differences were not statistically significant at 5%. In subgroup A1 X FEV1.0/CVF was 83.41 +/- 5.63% and in subgroup A2, 79.42 +/- 4.23%. Maximum mid-expiratory flow rate was 88.64 +/- 24.39% in subgroup A1 and 65.26 +/- 17.88% in subgroup A2. These differences were statistically significant at 1%. In group B, FEV1.0/FVC was always less than 75%. In subgroup B1 it was 68.24 +/- 10.43% and in B2, 64.90 +/- 10.43% and values for FEF25-75% were 48.13 +/- 16.48% and 42.79 +/- 17.68%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Subject(s)
Bronchial Diseases/diagnosis , Adolescent , Adult , Age Factors , Aged , Bronchial Diseases/physiopathology , Female , Humans , Male , Maximal Midexpiratory Flow Rate , Middle Aged , Vital CapacityABSTRACT
Foram estudados 20 pacientes portadores de obstrucao bronquica atraves de provas espirometricas em condicoes basais e apos 10 minutos da inalacao de 0,5mg de terbutalina. Analisaram-se a capacidade vital forcada, o volume expiratorio forcado no primeiro segundo, o fluxo expiratorio forcado na porcao media da curva de capacidade vital e a correcao isovolume deste fluxo.Verificou-se, apos o broncodilatador, aumento nos valores destas variaveis, com excecao do fluxo medio que mostrou decrescimo em seis dos pacientes estudados. Apos o ajuste dos pontos 25 e 75% sobre a curva da capacidade vital, observou-se aumento significativo destes valores, caracterizando a importancia da correcao isovolume do fluxo medio expiratorio forcado
