ABSTRACT
No disponible
Subject(s)
Humans , Male , Middle Aged , Colonic Diseases/diagnostic imaging , Colon/abnormalities , Cysts/diagnostic imaging , Colonic Diseases/surgery , Colon/surgery , Cysts/surgeryABSTRACT
Antecedentes y objetivo: En el hipotálamo existen poblaciones neuronales involucradas en la regulación de la ingesta, destacando la ghrelina como hormona orexígena (estimula el apetito). Después de los diferentes procedimientos de cirugía bariátrica se han observado cambios en los niveles plasmáticos de ghrelina, siendo los resultados de los estudios contradictorios. Existen muchas lagunas en cuanto al papel que desempeña la ghrelina en el proceso de pérdida de peso después de cirugía bariátrica. Nuestro objetivo es describir el comportamiento de ghrelina en ayunas, comparando los cambios acontecidos en 2 técnicas quirúrgicas (bypass gástrico versus gastrectomía vertical) y su correlación con la pérdida ponderal. Pacientes y método: Estudio observacional de cohortes analíticas prospectivo, donde se incluyen 54 pacientes (27 por cada técnica quirúrgica) y un período de seguimiento de 12 meses. Se analizaron datos demográficos, datos antropométricos, comorbilidades, pérdida ponderal y evolución del comportamiento de ghrelina en ayunas. Resultados: Con ambas técnicas quirúrgicas el comportamiento de ghrelina acilada fue similar, sin diferencias significativas entre bypass gástrico y gastrectomía vertical. Con ambos procedimientos se produce un ascenso de ghrelina acilada al 5.o día y caída posterior, para luego ir ascendiendo hasta alcanzar valores superiores a los preoperatorios a los 12 meses. Este aumento en los niveles de ghrelina no afecta a la pérdida ponderal, ya que al año de la cirugía con las 2 técnicas quirúrgicas se alcanza un 30% de pérdida de peso. Conclusiones: Observamos un incremento de los niveles de ghrelina acilada en ayunas al año de seguimiento con ambas técnicas quirúrgicas, cuando existe una pérdida ponderal del 30%
Background and objective: Neuronal populations involved in the regulation of food intake, particularly the orexigenic (appetite-stimulating) hormone ghrelin, are found in the hypothalamus. Changes in plasma ghrelin levels have been observed following different bariatric surgery procedures, but the results from different studies are contradictory. Much remains unknown regarding the role of ghrelin in the weight loss process following bariatric surgery. Our objective was to describe the behaviour of fasting ghrelin levels, comparing the changes occurring between 2 different surgical techniques (gastric bypass versus vertical sleeve gastrectomy) and their correlation with weight loss. Patients and method: A prospective, observational, analytic cohort study of 54 patients (27 for each surgical technique) with a 12-month follow-up period. We analysed demographic data, anthropometric data, comorbidities, weight loss and evolution of fasting ghrelin. Results: The behaviour of acylated ghrelin was similar with the 2 surgical techniques, with no significant differences between gastric bypass and vertical sleeve gastrectomy. With both procedures, there was an increase in acylated ghrelin on day 5 and a subsequent decrease, and levels then gradually increased to reach values at 12 months that were higher than those reported preoperatively. This increase in ghrelin levels did not affect weight loss, since one year post-surgery, 30% weight loss was achieved with both types of surgery. Conclusions: We observed an increase in fasting acylated ghrelin levels at one year of follow-up with both surgical techniques, with 30% weight los
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Ghrelin/administration & dosage , Cohort Studies , Gastric Bypass , Gastrectomy , Bariatric Surgery/methods , Ghrelin/metabolism , Prospective Studies , Anthropometry , Body Mass Index , Weight Loss , Ghrelin/pharmacologyABSTRACT
BACKGROUND AND OBJECTIVE: Neuronal populations involved in the regulation of food intake, particularly the orexigenic (appetite-stimulating) hormone ghrelin, are found in the hypothalamus. Changes in plasma ghrelin levels have been observed following different bariatric surgery procedures, but the results from different studies are contradictory. Much remains unknown regarding the role of ghrelin in the weight loss process following bariatric surgery. Our objective was to describe the behaviour of fasting ghrelin levels, comparing the changes occurring between 2 different surgical techniques (gastric bypass versus vertical sleeve gastrectomy) and their correlation with weight loss. PATIENTS AND METHOD: A prospective, observational, analytic cohort study of 54 patients (27 for each surgical technique) with a 12-month follow-up period. We analysed demographic data, anthropometric data, comorbidities, weight loss and evolution of fasting ghrelin. RESULTS: The behaviour of acylated ghrelin was similar with the 2 surgical techniques, with no significant differences between gastric bypass and vertical sleeve gastrectomy. With both procedures, there was an increase in acylated ghrelin on day 5 and a subsequent decrease, and levels then gradually increased to reach values at 12 months that were higher than those reported preoperatively. This increase in ghrelin levels did not affect weight loss, since one year post-surgery, 30% weight loss was achieved with both types of surgery. CONCLUSIONS: We observed an increase in fasting acylated ghrelin levels at one year of follow-up with both surgical techniques, with 30% weight loss.
Subject(s)
Fasting/blood , Gastrectomy/methods , Gastric Bypass , Ghrelin/blood , Obesity, Morbid/blood , Obesity, Morbid/surgery , Weight Loss , Adult , Cohort Studies , Correlation of Data , Female , Humans , Male , Middle AgedABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Leiomyomatosis/diagnosis , Peritoneal Neoplasms/diagnosis , Leiomyomatosis/pathology , Leiomyomatosis/surgery , Peritoneal Neoplasms/pathology , Positron Emission Tomography Computed TomographyABSTRACT
No disponible
Subject(s)
Humans , Male , Aged , Gastroesophageal Reflux/diagnostic imaging , Gastroesophageal Reflux/surgery , Laparoscopy/methods , Gastroscopy/instrumentation , Gastroscopy/methods , Biopsy , Hyaluronic Acid/administration & dosage , Chondroitin/administration & dosage , Duodenum/surgerySubject(s)
Duodenal Obstruction/complications , Duodenum/surgery , Gastric Bypass/methods , Gastroesophageal Reflux/complications , Intestinal Atresia/complications , Laparoscopy/methods , Stomach Ulcer/complications , Vagotomy, Truncal/methods , Aged , Duodenal Obstruction/surgery , Gastroesophageal Reflux/diagnostic imaging , Gastroesophageal Reflux/surgery , Gastroscopy , Humans , Intestinal Atresia/surgery , Male , Stomach Ulcer/diagnostic imaging , Stomach Ulcer/surgeryABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Breast Neoplasms/pathology , Carcinosarcoma/pathology , Mastectomy , Neoplasm Recurrence, Local/prevention & control , Neoplasm Metastasis/prevention & control , Lymphatic Metastasis/prevention & controlABSTRACT
No disponible
Subject(s)
Humans , Female , Aged , Adrenal Gland Neoplasms/diagnostic imaging , Calcinosis/diagnostic imaging , Cysts/diagnostic imaging , Diagnosis, DifferentialABSTRACT
No disponible
Subject(s)
Humans , Male , Aged, 80 and over , Intestinal Obstruction/complications , Diverticulum/complications , Intestinal Volvulus/diagnosis , Jejunal Diseases/complications , Incidental Findings , Diverticulum/surgerySubject(s)
Foreign Bodies/diagnostic imaging , Rectum , Tomography, X-Ray Computed , Aged , Humans , MaleSubject(s)
Diverticulum/complications , Intestinal Obstruction/etiology , Jejunal Diseases/etiology , Abdominal Pain/etiology , Aged, 80 and over , Diverticulum/diagnostic imaging , Diverticulum/surgery , Fatal Outcome , Humans , Intestinal Obstruction/diagnostic imaging , Intestinal Obstruction/surgery , Ischemia/etiology , Jejunal Diseases/diagnostic imaging , Jejunal Diseases/surgery , Jejunum/blood supply , Male , Postoperative Complications/etiology , Pulmonary Edema/etiologyABSTRACT
No disponible
Subject(s)
Humans , Male , Middle Aged , Aged , Intestinal Obstruction/etiology , Lung Neoplasms/pathology , Intestinal Neoplasms/secondary , Neoplasm Metastasis/pathology , Intestine, Small/pathologySubject(s)
Carcinoma, Small Cell/secondary , Carcinoma, Squamous Cell/secondary , Ileal Diseases/etiology , Intestinal Obstruction/etiology , Jejunal Diseases/etiology , Jejunal Neoplasms/secondary , Lung Neoplasms/complications , Aged , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Carcinoma, Small Cell/complications , Carcinoma, Small Cell/drug therapy , Carcinoma, Squamous Cell/complications , Carcinoma, Squamous Cell/drug therapy , Carcinoma, Squamous Cell/surgery , Chemoradiotherapy , Cisplatin/administration & dosage , Etoposide/administration & dosage , Fatal Outcome , Humans , Ileal Diseases/diagnostic imaging , Intestinal Obstruction/diagnostic imaging , Intestinal Obstruction/surgery , Jejunal Diseases/diagnostic imaging , Jejunal Neoplasms/complications , Lung Neoplasms/diagnostic imaging , Lung Neoplasms/therapy , Male , Middle AgedABSTRACT
No disponible
Subject(s)
Aged , Female , Humans , Male , Middle Aged , Gastrointestinal Stromal Tumors/complications , Neoplasms, Multiple Primary/epidemiology , Neoplasms, Multiple Primary/prevention & control , Immunohistochemistry/methods , Gastroscopy/methods , Laparotomy/methods , Chemotherapy, Adjuvant/methods , Gastrointestinal Stromal Tumors/epidemiology , Gastrointestinal Stromal Tumors/prevention & control , Colonoscopy/methods , Sigmoid NeoplasmsABSTRACT
No disponible
Subject(s)
Humans , Female , Aged , Seroma/diagnosis , Femoral Artery/surgery , Arteriovenous Anastomosis , Endovascular ProceduresABSTRACT
No disponible