Subject(s)
Humans , Male , Female , Thoracic Surgery , /surgery , Anesthesia/methods , Anesthesiology/instrumentation , Intubation , Perioperative PeriodSubject(s)
COVID-19 , Thoracic Surgery , Thoracic Surgical Procedures , Humans , Perioperative Care , SARS-CoV-2Subject(s)
COVID-19/prevention & control , Intubation, Intratracheal/methods , Perioperative Care/methods , Practice Guidelines as Topic , Thoracic Surgical Procedures/methods , Airway Extubation/standards , Anesthesia/standards , Bronchoscopy/instrumentation , Bronchoscopy/methods , Bronchoscopy/standards , Humans , Intubation, Intratracheal/standards , Laryngoscopy/methods , Perioperative Care/standards , Thoracic Surgical Procedures/standardsABSTRACT
OBJECTIVE: To assess quality of life of children and teenagers with recurrent respiratory papillomatosis, according to the evidence of infection by human papillomavirus types 6 and 11, compared with healthy volunteers and patients with chronic otitis media. METHOD: Participants and their parents completed the Pediatric Quality of Life Inventory 4.0. RESULTS: Patients with recurrent respiratory papillomatosis and their parents reported lower quality of life than healthy subjects (p < 0.01), but similar quality of life to patients with chronic otitis media. Those with human papillomavirus type 11 showed the lowest scores among all participants (p < 0.05). CONCLUSION: Young Mexican patients with recurrent respiratory papillomatosis and their parents perceive a poor quality of life, and they may experience limitations in interactions with their peers. Infection by human papillomavirus type 11 may increase the impact of the disease on quality of life.
Subject(s)
Papillomavirus Infections/psychology , Quality of Life , Respiratory Tract Infections/psychology , Adolescent , Case-Control Studies , Child , Chronic Disease , Female , Human papillomavirus 11 , Human papillomavirus 6 , Humans , Male , Mexico , Neoplasm Recurrence, Local/psychology , Otitis Media/psychology , Papillomavirus Infections/virology , Parents/psychology , Recurrence , Respiratory Tract Infections/virology , Surveys and QuestionnairesABSTRACT
The interaction between nickel and yeast hexokinase was studied. The binding of nickel showed a positive cooperativity, and saturation was not reached. The nickel binding induced modifications in the secondary structure of the protein; thus, a lost of alpha helix and beta turns, as well as an increase of the random structure and beta sheet was observed. The monomer/dimmer equilibrium of the protein was modified in the presence of nickel, and the monomer state was mainly obtained at the highest nickel concentrations studied. These changes on the protein structure caused a decrease in the enzyme activity. According to kinetic studies, nickel caused a non-competitive inhibition when glucose was the variable substrate and a linear competitive inhibition when ATP was the variable substrate.
