["The break in care": Mothers' experiences with alcohol abuse and care in Mexico]. / "La ruptura en el cuidado": Experiencias de mujeres madres con abuso de alcohol y su atención en México.

This article aims to analyze the experiences related to motherhood and care among mothers who attend mutual support groups to address alcohol-related harm in Mexico City and the State of Mexico. Drawing on the conceptual framework of collective health from a gender perspective, we contend that socioeconomic and gender-related factors influence the social determination of alcoholism and the health-disease-attention-care process. A qualitative study was conducted between May 2020 and January 2021, which included interviews with ten women who were selected based on specific criteria, as well as non-participant observation in a women's Alcoholics Anonymous group. The main findings show how trajectories of alcohol abuse and its management are interconnected with trajectories of care. From there, it was possible to identify a "break in care," a category that sheds light on mistreatment and the precariousness of life and health of women and their children.

Este artículo se propone analizar las experiencias sobre la maternidad y los cuidados de mujeres madres que asisten a grupos de apoyo mutuo en la Ciudad de México y el Estado de México para autoatender los daños asociados al alcohol. A partir del marco conceptual de la salud colectiva y la perspectiva de género, se concibe que la condición de género y socioeconómica inciden en la determinación social del alcoholismo y en el proceso salud-enfermedad-atención-cuidado. Desde este enfoque, de mayo de 2020 a enero de 2021, se realizó un estudio cualitativo, en el que se entrevistó a diez mujeres elegidas bajo ciertos criterios y se realizó observación no participante en un grupo femenino Alcohólicos Anónimos. Entre los principales resultados, se reconoce una trayectoria de abuso de alcohol y su atención, concatenada con la trayectoria de cuidados. Este hallazgo delimitó la categoría de "ruptura en el cuidado" para develar el maltrato, la precarización de vida y salud de las mujeres y sus hijos e hijas.

Impact of coronavirus disease 2019 (COVID-19) pandemic in hospital-acquired infections and bacterial resistance at an oncology hospital.

Objective: Hospital-acquired infection (HAI) rates were negatively affected by the the coronavirus disease 2019 (COVID-19) pandemic. We describe the incidence of HAIs, main pathogens, and multidrug-resistant organisms (MDROs) isolated in cancer patients before and during the pandemic. Design: This retrospective, comparative study included patients with HAIs. We compared 2 periods: the prepandemic period (2018, 2019, and the first 3 months of 2020) with the pandemic period (April-December 2020 and all of 2021). Setting: Instituto Nacional de Cancerología, a tertiary-care oncology public hospital in Mexico City, Mexico. Methods: Patients with the following HAIs were included: nosocomial pneumonia, ventilator-associated pneumonia (VAP), secondary bloodstream infection (BSI), central-line-associated bloodstream infection (CLBSI), and Clostridioides difficile infection (CDI). Demographic data, clinical characteristics, pathogens isolated, and MDRO data were included. Results: We identified 639 HAIs: 381 (7.95 per 100 hospital discharges) in the prepandemic period and 258 (7.17 per 100 hospital discharges) in the pandemic period. Hematologic malignancy was documented in 263 (44.3%) patients; 251 (39.2%) were in cancer progression or relapse. Nosocomial pneumonia was more frequent during the pandemic period (40.3% vs 32.3%; P = .04). Total episodes of VAP were not different between the 2 periods (28.1% vs 22.1%; P = .08), but during the pandemic period, the VAP rate was higher among COVID-19 patients than non-COVID-19 patients (72.2% vs 8.8%; P < .001). Escherichia coli, Stenotrophomonas maltophilia, and Staphylococcus aureus bacteremia cases were more frequent in the pandemic period. Extended-spectrum ß-lactamases (ESBL)-E. coli was the only MDRO that occurred more frequently during the pandemic period. Conclusions: In cancer patients, nosocomial pneumonia was more frequent during the pandemic period. We did not observe a significant impact on other HAIs. MDROs did not significantly increase during the pandemic.

"La ruptura en el cuidado": Experiencias de mujeres madres con abuso de alcohol y su atención en México / "The break in care": Mothers' experiences with alcohol abuse and care in Mexico

RESUMEN Este artículo se propone analizar las experiencias sobre la maternidad y los cuidados de mujeres madres que asisten a grupos de apoyo mutuo en la Ciudad de México y el Estado de México para autoatender los daños asociados al alcohol. A partir del marco conceptual de la salud colectiva y la perspectiva de género, se concibe que la condición de género y socioeconómica inciden en la determinación social del alcoholismo y en el proceso salud-enfermedad-atención-cuidado. Desde este enfoque, de mayo de 2020 a enero de 2021, se realizó un estudio cualitativo, en el que se entrevistó a diez mujeres elegidas bajo ciertos criterios y se realizó observación no participante en un grupo femenino Alcohólicos Anónimos. Entre los principales resultados, se reconoce una trayectoria de abuso de alcohol y su atención, concatenada con la trayectoria de cuidados. Este hallazgo delimitó la categoría de "ruptura en el cuidado" para develar el maltrato, la precarización de vida y salud de las mujeres y sus hijos e hijas.

ABSTRACT This article aims to analyze the experiences related to motherhood and care among mothers who attend mutual support groups to address alcohol-related harm in Mexico City and the State of Mexico. Drawing on the conceptual framework of collective health from a gender perspective, we contend that socioeconomic and gender-related factors influence the social determination of alcoholism and the health-disease-attention-care process. A qualitative study was conducted between May 2020 and January 2021, which included interviews with ten women who were selected based on specific criteria, as well as non-participant observation in a women's Alcoholics Anonymous group. The main findings show how trajectories of alcohol abuse and its management are interconnected with trajectories of care. From there, it was possible to identify a "break in care," a category that sheds light on mistreatment and the precariousness of life and health of women and their children.

Multiannual assessment of the desert dust impact on air quality in Italy combining PM10 data with physics-based and geostatistical models.

Desert dust storms pose real threats to air quality and health of millions of people in source regions, with associated impacts extending to downwind areas. Europe (EU) is frequently affected by atmospheric transport of desert dust from the Northern Africa and Middle East drylands. This investigation aims at quantifying the role of desert dust transport events on air quality (AQ) over Italy, which is among the EU countries most impacted by this phenomenon. We focus on the particulate matter (PM) metrics regulated by the EU AQ Directive. In particular, we use multiannual (2006-2012) PM10 records collected in hundreds monitoring sites within the national AQ network to quantify daily and annual contributions of dust during transport episodes. The methodology followed was built on specific European Commission guidelines released to evaluate the natural contributions to the measured PM-levels, and was partially modified, tested and adapted to the Italian case in a previous study. Overall, we show that impact of dust on the yearly average PM10 has a clear latitudinal gradient (from less than 1 to greater than 10 µg/m3 going from north to south Italy), this feature being mainly driven by an increased number of dust episodes per year with decreasing latitude. Conversely, the daily-average dust-PM10 (≅12 µg/m3) is more homogenous over the country and shown to be mainly influenced by the site type, with enhanced values in more urbanized locations. This study also combines the PM10 measurements-approach with geostatistical modelling. In particular, exploiting the dust-PM10 dataset obtained at site- and daily-resolution over Italy, a geostatistical, random-forest model was set up to derive a daily, spatially-continuous field of desert-dust PM10 at high (1-km) resolution. This finely resolved information represent the basis for a follow up investigation of both acute and chronic health effects of desert dust over Italy, stemming from daily and annual exposures, respectively.

Atresia bronquial: Reporte de dos casos en población adulta / Bronchial Atresia. Report of Two Cases in Adults

La atresia bronquial (AB) es una anomalía congénita poco frecuente y de etiología desconocida. Se caracteriza por la falla en el desarrollo de una porción de un bronquio con acumulación de secreciones bronquiales y atrapamiento aéreo distal a la lesión. El conocimiento de esta patología permite su incorporación dentro de los diagnósticos diferenciales de masas pulmonares.

Bronchial atresia (BA) is an uncommon congenital anomaly of unknown etiology. It is characterized by the failure to develop a portion of the bronchus with accumulation of bronchial secretions and air trapping distal to the lesion. The knowledge of this pathology can be taken into account within the differential diagnosis of lung masses.

Crystal structures of two chiral piperidine derivatives: 1-[(1R)-2-hy-droxy-1-phenyl-eth-yl]piperidin-4-one and 8-[(1S)-1-phenyl-eth-yl]-1,4-dioxa-8-aza-spiro-[4.5]decane-7-thione.

The crystal structures of the two title piperidine derivatives show different conformations for the six-membered heterocycle. The N-substituted 4-piperidinone 1-[(1R)-2-hy-droxy-1-phenyl-eth-yl]piperidin-4-one, C13H17NO2, (I), has a chair conformation, while the piperidine substituted in position 2 with a thio-carbonyl group, 8-[(1S)-1-phenyl-eth-yl]-1,4-dioxa-8-aza-spiro-[4.5]decane-7-thione, C15H19NO2S, (II), features a half-chair conformation. Comparison of the two structures, and data retrieved from the literature, suggests that the conformational flexibility is mainly related to the hybridization state of the C atom α to the piperidinic N atom: a Csp (3) atom favours the chair conformer, while a Csp (2) atom distorts the ring towards a half-chair conformer. In the crystal structure of (I), weak C-H⋯O hydrogen bonds link the mol-ecules into supra-molecular chains propagating along the b-axis direction. In the crystal of (II), the mol-ecules are linked by weak C-H⋯S contacts into supra-molecular chains propagating along the b-axis direction.

2,2-Dimethyl-5-(2-nitro-benzyl-idene)-1,3-dioxane-4,6-dione.

The asymmetric unit of the title compound, C13H11NO6, contains two mol-ecules in both of which the six-membered 1,3-dioxane-4,6-dione ring shows a screw-boat conformation. The dihedral angles between the best planes through the six-membered rings are 47.8 (2) and 49.8 (2)°. In the crystal, C-H⋯O inter-actions link the mol-ecules, building a supramolecular sheet parallel to the c axis.

4-Hy-droxy-1,1'-bis-[(S)-1-phenyl-eth-yl]-5,5',6,6'-tetra-hydro-3,4'-bipyridine-2,2'(1H,1'H)-dione.

The title bis-piperidine, C26H28N2O3, was unexpectedly obtained via a dimerization mechanism promoted by acetic acid when performing the Dieckmann cyclization of a chiral amido ester. The S,S configuration was assigned by reference to the enanti-omerically pure starting material. In the mol-ecule, two core heterocycles are linked by a σ bond. One ring includes a keto-enol group, while the other presents an enone functionality. Both rings present a conformation inter-mediate between envelope and screw-boat, and the dihedral angle between the mean planes passing through the rings [48.9 (1)°] is large enough to avoid hindrance between ring substituents. The enol tautomeric form in one ring favors the formation of strong inter-molecular O-H⋯O=C hydrogen bonds. The resulting one-dimensional supra-molecular structure features single-stranded helices running along the 21 screw axis parallel to [100].

Second monoclinic form of (E)-3-(4-fluoro-phen-yl)-1-phenyl-prop-2-en-1-one.

The unit-cell dimensions and space group of the second monoclinic polymorph of the title compound, C15H11FO, differ from those of the previously reported form [Jing (2009 ▶). Acta Cryst. E65, o2515]. The title compound shows an E conformation of the C=C bond with the 4-fluoro-phenyl group opposite to the benzoyl group. The torsion angle of between the planes of the 4-fluoro-phenyl and benzoyl groups is 10.53 (6)°. In the crystal, weak C-H⋯O and C-H⋯F inter-actions form a cross-linked packing motif, building sheets parallel to (-102).

Insulin and phorbol ester regulation of gene 33 expression in CHO cells

Rat gene 33 (g33) mRNA has a widespread tissue distribution. Insulin and various agents such as glucocorticoids, phorbol esters and plant lectins regulate G33 expression in rat hepatoma cells. The regulation of g33 by insulin and a phorbol ester was examined in two Chinese Hamster ovary (CHO) cell lines, CHO-T cells (which overexpress human insulin receptors (hIR)) and wild type CHOwt cells. These cell lines were used to determine how expression of the hIR influences the capacity of g33 to respond to insulin and phorbol myristate acetate (PMA). Treatment of CHOwt and CHO-T cells with insulin increased mRNAg33 levels three to four-fold, with a maximum effect reached after three hours of treatment. PMA treatment of CHOwt and CHO-T cells caused a similar elevation of mRNAg33 levels after three hours. Insulin had no effect on mRNAg33 stability in both CHO cell lines. Additionally, the effects of insulin and PMA on mRNAg33 levels were additive only in CHO-T cells. Insulin or PMA-pretreated CHO-T cells were able to respond to both agents, but elevation ofmRNAg33 levels was maximal. In contrast, when insulin and/or PMA-pretreated CHOwt cells were exposed to insulin or PMA, g33 was able to respond maximally. These results suggest that insulin and phorbol esters act through different signaling mechanisms in CHOwt cells. Additionally, insulin's ability to stimulate g33 expression in CHOwt cells suggests that this insulin effect may be independent of the insulin eceptor. There are differences in the regulation pattern of g33 by insulin and PMA in rat hepatoma and among the two CHO cell lines used in this study