Subject(s)
Humans , Female , Adult , Middle Aged , Lymphoma, Large B-Cell, Diffuse/diagnostic imaging , Lymphoma, Large B-Cell, Diffuse/psychology , Breast Neoplasms/diagnostic imaging , Leukemia, Myeloid/diagnostic imaging , Leukemia, Myeloid/pathology , Fluorodeoxyglucose F18 , Radiopharmaceuticals , Positron-Emission Tomography , Neoplasm InvasivenessABSTRACT
PURPOSE: Autophagy has lately emerged as an important biological process with implications in several hematological pathologies. Recently, a growing body of evidence supports a putative role of autophagy in chronic lymphocytic leukemia; however, no definitive clue has been established so far. To elucidate this issue, we have developed a pilot study to measure autophagic flux in peripheral blood mononuclear cells from chronic lymphocytic leukemia patients, and explored its correlation with classical clinical/analytical parameters. METHODS/PATIENTS: Thirty-three chronic lymphocytic leukemia patients participated in the study. Autophagic flux in peripheral blood mononuclear cells was determined by western blot measuring the levels of the proteins p62 and lipidated LC3. Moreover, p62 mRNA levels were analyzed by RT-qPCR. RESULTS: Lymphocytosis and the percentage of tumoral lymphocytes in chronic lymphocytic leukemia patients statistically correlate with a blocked autophagic flux. CONCLUSION: Alterations in autophagic flux could play an important role in the physiopathology of chronic lymphocytic leukemia.
Subject(s)
Autophagy , Biomarkers, Tumor/metabolism , Leukemia, Lymphocytic, Chronic, B-Cell/pathology , Leukocytes, Mononuclear/pathology , Lymphocytosis/pathology , Aged , Aged, 80 and over , Female , Follow-Up Studies , Humans , Leukemia, Lymphocytic, Chronic, B-Cell/metabolism , Leukocytes, Mononuclear/metabolism , Lymphocytosis/metabolism , Male , Middle Aged , Pilot Projects , PrognosisABSTRACT
No disponible
No disponible
Subject(s)
Humans , Abdominal Wall/physiology , Hematoma/prevention & control , Heparin, Low-Molecular-Weight/administration & dosage , Heparin, Low-Molecular-Weight/adverse effects , Hematoma/etiology , Muscular Diseases/prevention & controlSubject(s)
Antibodies, Bacterial/blood , Coxiella burnetii/isolation & purification , Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications , Q Fever/complications , Anti-Bacterial Agents/therapeutic use , Antineoplastic Agents/therapeutic use , Breast Neoplasms/complications , Breast Neoplasms/drug therapy , Coxiella burnetii/immunology , Fatal Outcome , Female , Humans , Middle Aged , Precursor Cell Lymphoblastic Leukemia-Lymphoma/blood , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Q Fever/diagnosis , Q Fever/drug therapyABSTRACT
No disponible
Subject(s)
Female , Middle Aged , Humans , Antibodies, Bacterial , Q Fever , Precursor Cell Lymphoblastic Leukemia-Lymphoma , Fatal Outcome , Coxiella burnetii , Antineoplastic Agents , Anti-Bacterial Agents , Breast NeoplasmsABSTRACT
The acute chest syndrome is a clinical entity appearing in patients suffering from sickle cell anaemia. It presents with pleuritic pain, fever, leucocytosis and pulmonary infiltrates in the thoracic radiology. The etiological diagnosis is difficult, and it is necessary to distinguish between pneumonia and pulmonary infarction. This syndrome is quite frequent among the patients at risk, and can be lethal according to the severity and the etiology of the event. A case of acute chest syndrome due to a S. pneumoniae sepsis is presented. The interest of the case lies in the rareness of this disease in our population and the peculiar evolutive clinical features of this case, with the development of intracranial hypertension and death.
