Current trends in tendinopathy: consensus of the ESSKA basic science committee. Part I: biology, biomechanics, anatomy and an exercise-based approach.

Chronic tendinopathies represent a major problem in the clinical practice of sports orthopaedic surgeons, sports doctors and other health professionals involved in the treatment of athletes and patients that perform repetitive actions. The lack of consensus relative to the diagnostic tools and treatment modalities represents a management dilemma for these professionals. With this review, the purpose of the ESSKA Basic Science Committee is to establish guidelines for understanding, diagnosing and treating this complex pathology.

Efficacy of an inertial resistance training paradigm in the treatment of patellar tendinopathy in athletes: a case-series study.

STUDY DESIGN: Case-series study with pre- vs. post-test measurements design. BACKGROUND: Strength training programs emphasizing eccentric muscle actions have received much attention in the treatment of tendinopathies. The current study reports on the efficacy of a novel strength training paradigm using inertial eccentric-concentric resistance to treat chronic patellar tendinopathy. CASE DESCRIPTION: Ten athletes with chronic patellar tendinopathy (15 tendons) volunteered for the study. Subjects completed a 6-week training program employing a leg press flywheel ergometer. Pre and post measurements assessed lower limb maximal strength and vertical counter-movement-jump (CMJ) height. Surface electromyography (SEMG) analysis of paraspinal, rectus femoris, biceps femoris and medial gastrocnemius muscles were collected. All measurements were performed one week before and after the training period. Clinical measures of pain and tendon function were assessed by means of a visual analogue scale (VAS) and a patellar tendinopathy questionnaire (VISA) at baseline, post-training and follow-up (12 wk). The Wilcoxon signed-rank test was employed for data comparisons. RESULTS: Eccentric strength increased after training (90%, p < 0.05). Similarly, VAS and VISA scores improved after training as well (60% and 86%, respectively, p < 0.01). There were no changes in CMJ height. CONCLUSION: Short-term training using inertial eccentric overload, resulted in improved muscle function and reduced subjective pain in long-lasting patellar tendinopathy.

Risk factors for immune reconstitution inflammatory syndrome under combination antiretroviral therapy can be aetiology-specific.

In order to discriminate general from aetiology-specific risk factors for immune reconstitution inflammatory syndrome (IRIS), we followed up, during six months, 99 patients with advanced HIV infection commencing antiretroviral therapy (ART) without active opportunistic infections or evident inflammation. IRIS predictors were determined by univariate analysis using clinical data from 76 ART-responding patients either completing follow-up or developing IRIS, and by multivariate analysis of inflammation, disease progression and nutrition status variables. We identified 23 primary IRIS events (30.3%). Univariate predictors for all IRIS events were higher platelet counts and lower CD4/CD8 ratio, whereas subclinical inflammation was the multivariate predictor. Platelets, alkaline phosphatase levels and %CD8 T-cells in univariate analysis also predicted mycobacteria-associated IRIS independently, remaining elevated during follow-up. Herpesvirus IRIS was predicted by platelets and inflammation. Indicators of advanced HIV disease and subclinical inflammation jointly predict IRIS, and some are specific of the underlying microbial aetiology, possibly explaining previous reports.