ABSTRACT
Acute pharyngitis and tonsillitis are one of the most freguent illnesses. Most of episodes of the sore throat are coused by viral agents.Groupe A beta - hemolitic streptococcus still dominantes emong bacterial pathogens in upper respiratory tract infections and their late sequelae like rheumatic ferer determines the necessity of intensive therapy. Diagnosis should be made basing on results of clinical manifestations in conjunction with microbiological and serological tests. An inereased serum antibody titers to streptolisin O (antistreptolisin O -ASO) is usually indicative of recent streptococcal infection not active rheumatic fever.
Subject(s)
Antistreptolysin/blood , Pharyngitis/diagnosis , Streptococcal Infections/diagnosis , Streptolysins/blood , Tonsillitis/diagnosis , Acute Disease , Bacterial Proteins/blood , Humans , Serologic TestsABSTRACT
BACKGROUND: The presence of antiphospholipid antibodies (APA), especially anticardiolipin antibodies (ACA), antibodies against beta2-glikoprotein I and lupus anticoagulant leads to thrombotic disorders. The pathogenetic role of APA in children is not exactly explained. The frequency of occurrence of APA and antiphospholipid syndrom in children is 2 to 3 times lower than in adults. OBJECTIVES: The aim of the study was to indicate the presence of ACA in circulating immunological complexes (CIC) from sera of patients suffering from juvenile idiopathic arthritis (JIA) and juvenile systemic lupus erythematosus (JSLE). PATIENTS AND METHODS: 31 sera were investigated, 16 from JIA patients and 15 from JSLE patients. The free ACA IgG class, ACA bound in CIC were estimated by the ELISA method (after dissociation of CIC and y-fraction paecipitation). RESULTS: In CIC isolated from sera of JIA and JSLE patients ACA were discovered. ACA, possessing high avidity, in CIC were more frequently discovered than unbound ACA (38.7% vs. 25.8%). CONCLUSIONS: ACA in CIC were more frequent in sera of JIA patients, unbound ACA were more frequent in sera of JSLE patients.
Subject(s)
Antibodies, Anticardiolipin/blood , Antigen-Antibody Complex/blood , Arthritis, Juvenile/immunology , Lupus Erythematosus, Systemic/immunology , Adolescent , Child , Child, Preschool , Female , Humans , MaleSubject(s)
Antibodies, Antiphospholipid/analysis , Antiphospholipid Syndrome/immunology , Lupus Erythematosus, Systemic/immunology , Adolescent , Antibodies, Anticardiolipin/analysis , Autoantibodies , Autoimmune Diseases , Child , Humans , Lupus Coagulation Inhibitor/analysis , Lupus Erythematosus, Systemic/complications , Risk Factors , Thrombocytopenia/etiology , Thrombosis/etiology , beta 2-Glycoprotein IABSTRACT
The author presented the present classification, clinical course, diagnostic and prognostic problems and own remarks in juvenile systemic lupus erythematosus and juvenile dermatomyositis.
Subject(s)
Dermatomyositis , Lupus Erythematosus, Systemic , Dermatomyositis/diagnosis , Dermatomyositis/therapy , Diagnosis, Differential , Humans , Lupus Erythematosus, Systemic/diagnosis , Lupus Erythematosus, Systemic/therapy , PrognosisABSTRACT
The investigation was carried out to determine the prevalence of back pain among the population of the school-children aged from 6 to 17 yrs. 3386 children from primary Warsaw schools randomly chosen, were investigated according to the questionnaire based on the diagnostic criteria of juvenile spondyloarthropathies (JSA). Total prevalence of spinal pain was 10.14%. Back pain occurred more frequently than the low - back and cervical pain (5.1% vs 3.44% and 3.04%). The incidence of painful episodes was highest between the age 12 - 15 yrs. Although no definite spondyloarthropathy was found among the investigated children - spinal pain occurred most frequently in those who showed one of the signs included into JSA criteria. This may imply the presence of a risk factor for developing spondyloarthropathy in the future.
