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Synthesis of new (benzimidazolyl)piperazines with affinity for the 5-HT1A receptor via Pd(0) amination of bromobenzimidazoles.
López-Rodríguez, M L; Viso, A; Benhamú, B; Rominguera, J L; Murcia, M.
Bioorg Med Chem Lett ; 9(16): 2339-42, 1999 Aug 16.
Article in English | MEDLINE | ID: mdl-10476865

ABSTRACT

The synthesis of a new family of (benzimidazolyl)piperazines has been developed through Pd(0) mediated amination of 4- and 6-bromobenzimidazole derivatives. Preliminary studies showed that some of these compounds are potent 5-HT1A receptor ligands.


Subject(s)
Benzimidazoles/metabolism , Piperazines/chemical synthesis , Receptors, Serotonin/metabolism , Amination , Animals , Cerebral Cortex/metabolism , In Vitro Techniques , Piperazines/metabolism , Radioligand Assay , Rats , Receptors, Serotonin, 5-HT1 , Structure-Activity Relationship
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